Causal associations between thyroid cancer and IgA nephropathy: a Mendelian randomization study
Abstract Background The incidence of kidney disease caused by thyroid cancer is rising worldwide. Observational studies cannot recognize whether thyroid cancer is independently associated with kidney disease. We performed the Mendelian randomization (MR) approach to genetically investigate the causa...
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | BMC Genomics |
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| Online Access: | https://doi.org/10.1186/s12864-023-09633-6 |
| _version_ | 1797577947875377152 |
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| author | Ziwei Mei Fuhao Li Ruizhen Chen Zilong Xiao Dongsheng Cai Lie Jin Xu Qian Yucheng Wang Jun Chen |
| author_facet | Ziwei Mei Fuhao Li Ruizhen Chen Zilong Xiao Dongsheng Cai Lie Jin Xu Qian Yucheng Wang Jun Chen |
| author_sort | Ziwei Mei |
| collection | DOAJ |
| description | Abstract Background The incidence of kidney disease caused by thyroid cancer is rising worldwide. Observational studies cannot recognize whether thyroid cancer is independently associated with kidney disease. We performed the Mendelian randomization (MR) approach to genetically investigate the causality of thyroid cancer on immunoglobulin A nephropathy (IgAN). Methods and results We explored the causal effect of thyroid cancer on IgAN by MR analysis. Fifty-two genetic loci and single nucleotide polymorphisms were related to thyroid cancer. The primary approach in this MR analysis was the inverse variance weighted (IVW) method, and MR‒Egger was the secondary method. Weighted mode and penalized weighted median were used to analyze the sensitivity. In this study, the random-effect IVW models showed the causal impact of genetically predicted thyroid cancer across the IgAN risk (OR, 1.191; 95% CI, 1.131–1.253, P < 0.001). Similar results were also obtained in the weighted mode method (OR, 1.048; 95% CI, 0.980–1.120, P = 0.179) and penalized weighted median (OR, 1.185; 95% CI, 1.110–1.264, P < 0.001). However, the MR‒Egger method revealed that thyroid cancer decreased the risk of IgAN, but this difference was not significant (OR, 0.948; 95% CI, 0.855–1.051, P = 0.316). The leave-one-out sensitivity analysis did not reveal the driving influence of any individual SNP on the association between thyroid cancer and IgAN. Conclusion The IVW model indicated a significant causality of thyroid cancer with IgAN. However, MR‒Egger had a point estimation in the opposite direction. According to the MR principle, the evidence of this study did not support a stable significant causal association between thyroid cancer and IgAN. The results still need to be confirmed by future studies. |
| first_indexed | 2024-03-10T22:15:17Z |
| format | Article |
| id | doaj.art-52fdf53683fd4e09a706e90ff41b7012 |
| institution | Directory Open Access Journal |
| issn | 1471-2164 |
| language | English |
| last_indexed | 2024-03-10T22:15:17Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genomics |
| spelling | doaj.art-52fdf53683fd4e09a706e90ff41b70122023-11-19T12:27:16ZengBMCBMC Genomics1471-21642023-09-0124111010.1186/s12864-023-09633-6Causal associations between thyroid cancer and IgA nephropathy: a Mendelian randomization studyZiwei Mei0Fuhao Li1Ruizhen Chen2Zilong Xiao3Dongsheng Cai4Lie Jin5Xu Qian6Yucheng Wang7Jun Chen8Zhejiang Chinese Medical UniversityZhejiang Chinese Medical UniversityDepartment of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Shanghai Medical College of Fudan UniversityDepartment of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Shanghai Medical College of Fudan UniversityDepartment of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang UniversityLishui Municipal Central hospitalDepartment of Clinical Laboratory, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of SciencesDepartment of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Shanghai Medical College of Fudan UniversityZhejiang Chinese Medical UniversityAbstract Background The incidence of kidney disease caused by thyroid cancer is rising worldwide. Observational studies cannot recognize whether thyroid cancer is independently associated with kidney disease. We performed the Mendelian randomization (MR) approach to genetically investigate the causality of thyroid cancer on immunoglobulin A nephropathy (IgAN). Methods and results We explored the causal effect of thyroid cancer on IgAN by MR analysis. Fifty-two genetic loci and single nucleotide polymorphisms were related to thyroid cancer. The primary approach in this MR analysis was the inverse variance weighted (IVW) method, and MR‒Egger was the secondary method. Weighted mode and penalized weighted median were used to analyze the sensitivity. In this study, the random-effect IVW models showed the causal impact of genetically predicted thyroid cancer across the IgAN risk (OR, 1.191; 95% CI, 1.131–1.253, P < 0.001). Similar results were also obtained in the weighted mode method (OR, 1.048; 95% CI, 0.980–1.120, P = 0.179) and penalized weighted median (OR, 1.185; 95% CI, 1.110–1.264, P < 0.001). However, the MR‒Egger method revealed that thyroid cancer decreased the risk of IgAN, but this difference was not significant (OR, 0.948; 95% CI, 0.855–1.051, P = 0.316). The leave-one-out sensitivity analysis did not reveal the driving influence of any individual SNP on the association between thyroid cancer and IgAN. Conclusion The IVW model indicated a significant causality of thyroid cancer with IgAN. However, MR‒Egger had a point estimation in the opposite direction. According to the MR principle, the evidence of this study did not support a stable significant causal association between thyroid cancer and IgAN. The results still need to be confirmed by future studies.https://doi.org/10.1186/s12864-023-09633-6Thyroid cancerIgA nephropathyMendelian randomizationGenetics |
| spellingShingle | Ziwei Mei Fuhao Li Ruizhen Chen Zilong Xiao Dongsheng Cai Lie Jin Xu Qian Yucheng Wang Jun Chen Causal associations between thyroid cancer and IgA nephropathy: a Mendelian randomization study BMC Genomics Thyroid cancer IgA nephropathy Mendelian randomization Genetics |
| title | Causal associations between thyroid cancer and IgA nephropathy: a Mendelian randomization study |
| title_full | Causal associations between thyroid cancer and IgA nephropathy: a Mendelian randomization study |
| title_fullStr | Causal associations between thyroid cancer and IgA nephropathy: a Mendelian randomization study |
| title_full_unstemmed | Causal associations between thyroid cancer and IgA nephropathy: a Mendelian randomization study |
| title_short | Causal associations between thyroid cancer and IgA nephropathy: a Mendelian randomization study |
| title_sort | causal associations between thyroid cancer and iga nephropathy a mendelian randomization study |
| topic | Thyroid cancer IgA nephropathy Mendelian randomization Genetics |
| url | https://doi.org/10.1186/s12864-023-09633-6 |
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