Authentication of Marantodes pumilum (Blume) Kuntze: A Systematic Review
Botanical drug products consist of complex phytochemical constituents that vary based on various factors that substantially produce different pharmacological activities and possible side effects. Marantodes pumilum (Blume) Kuntze (Primulaceae) is one of the most popular Malay traditional botanical d...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.855384/full |
| _version_ | 1828336105764683776 |
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| author | Ida Syazrina Ibrahim Mazlina Mohd Said Noraida Mohammad Zainoor Jamia Azdina Jamal |
| author_facet | Ida Syazrina Ibrahim Mazlina Mohd Said Noraida Mohammad Zainoor Jamia Azdina Jamal |
| author_sort | Ida Syazrina Ibrahim |
| collection | DOAJ |
| description | Botanical drug products consist of complex phytochemical constituents that vary based on various factors that substantially produce different pharmacological activities and possible side effects. Marantodes pumilum (Blume) Kuntze (Primulaceae) is one of the most popular Malay traditional botanical drugs and widely recognized for its medicinal use. Many studies have been conducted focusing on the identification of bioactive substances, pharmacological and toxicological activities in its specific varieties but less comprehensive study on M. pumilum authentication. Lack of quality control (QC) measurement assessment may cause different quality issues on M. pumilum containing products like adulteration by pharmaceutical substances, substitution, contamination, misidentification with toxic plant species, which may be detrimental to consumers’ health and safety. This systematic literature review aims to provide an overview of the current scenario on the quality control of botanical drug products as determined by pharmacopoeia requirements specifically for M. pumilum authentication or identification. A systematic search for peer-reviewed publications to document literature search for M. pumilum authentication was performed using four electronic databases: Web of Science, PubMed, Scopus and ScienceDirect for related studies from January 2010 to December 2021. The research studies published in English and related articles for identification or authentication of M. pumilum were the main inclusion criteria in this review. A total 122 articles were identified, whereby 33 articles met the inclusion criteria. Macroscopy, microscopy, chemical fingerprinting techniques using chromatography, spectroscopy and hyphenated techniques, and genetic-based fingerprinting using DNA barcoding method have been used to identify M. pumilum and to distinguish between different varieties and plant parts. The study concluded that a combination of approaches is necessary for authenticating botanical drug substances and products containing M. pumilum to assure the quality, safety, and efficacy of marketed botanical drug products, particularly those with therapeutic claims. |
| first_indexed | 2024-04-13T21:56:21Z |
| format | Article |
| id | doaj.art-5302997b6589420ea4d7620c9b542a9a |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-13T21:56:21Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-5302997b6589420ea4d7620c9b542a9a2022-12-22T02:28:15ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-06-011310.3389/fphar.2022.855384855384Authentication of Marantodes pumilum (Blume) Kuntze: A Systematic ReviewIda Syazrina Ibrahim0Mazlina Mohd Said1Noraida Mohammad Zainoor2Jamia Azdina Jamal3Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaDrug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaNational Pharmaceutical Regulatory Agency, Petaling Jaya, MalaysiaDrug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaBotanical drug products consist of complex phytochemical constituents that vary based on various factors that substantially produce different pharmacological activities and possible side effects. Marantodes pumilum (Blume) Kuntze (Primulaceae) is one of the most popular Malay traditional botanical drugs and widely recognized for its medicinal use. Many studies have been conducted focusing on the identification of bioactive substances, pharmacological and toxicological activities in its specific varieties but less comprehensive study on M. pumilum authentication. Lack of quality control (QC) measurement assessment may cause different quality issues on M. pumilum containing products like adulteration by pharmaceutical substances, substitution, contamination, misidentification with toxic plant species, which may be detrimental to consumers’ health and safety. This systematic literature review aims to provide an overview of the current scenario on the quality control of botanical drug products as determined by pharmacopoeia requirements specifically for M. pumilum authentication or identification. A systematic search for peer-reviewed publications to document literature search for M. pumilum authentication was performed using four electronic databases: Web of Science, PubMed, Scopus and ScienceDirect for related studies from January 2010 to December 2021. The research studies published in English and related articles for identification or authentication of M. pumilum were the main inclusion criteria in this review. A total 122 articles were identified, whereby 33 articles met the inclusion criteria. Macroscopy, microscopy, chemical fingerprinting techniques using chromatography, spectroscopy and hyphenated techniques, and genetic-based fingerprinting using DNA barcoding method have been used to identify M. pumilum and to distinguish between different varieties and plant parts. The study concluded that a combination of approaches is necessary for authenticating botanical drug substances and products containing M. pumilum to assure the quality, safety, and efficacy of marketed botanical drug products, particularly those with therapeutic claims.https://www.frontiersin.org/articles/10.3389/fphar.2022.855384/fullauthenticationidentificationfingerprintingMarantodes pumilumquality control |
| spellingShingle | Ida Syazrina Ibrahim Mazlina Mohd Said Noraida Mohammad Zainoor Jamia Azdina Jamal Authentication of Marantodes pumilum (Blume) Kuntze: A Systematic Review Frontiers in Pharmacology authentication identification fingerprinting Marantodes pumilum quality control |
| title | Authentication of Marantodes pumilum (Blume) Kuntze: A Systematic Review |
| title_full | Authentication of Marantodes pumilum (Blume) Kuntze: A Systematic Review |
| title_fullStr | Authentication of Marantodes pumilum (Blume) Kuntze: A Systematic Review |
| title_full_unstemmed | Authentication of Marantodes pumilum (Blume) Kuntze: A Systematic Review |
| title_short | Authentication of Marantodes pumilum (Blume) Kuntze: A Systematic Review |
| title_sort | authentication of marantodes pumilum blume kuntze a systematic review |
| topic | authentication identification fingerprinting Marantodes pumilum quality control |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.855384/full |
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