One-Pot Synthesis of Ag/Quaternary Ammonium Salt Co-Decorated Mesoporous Silica Nanoparticles for Synergistic Treatment of Cancer and Bacterial Infections
Developing drug delivery nanosystems with both anticancer and antibacterial effects is of great clinical value. Herein, we report a facile approach to synthesize Ag and quaternary ammonium salt (QAS) co-decorated mesoporous silica nanoparticles (MSNs), namely, Ag/QAS-MSNs, for synergistic treatment...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.875317/full |
| _version_ | 1818048746015948800 |
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| author | Hanyuan Zhang Jianxiang Xu Xu Zhang Teng Wang Dairan Zhou Wei Shu Tingting Zhao Weijun Fang |
| author_facet | Hanyuan Zhang Jianxiang Xu Xu Zhang Teng Wang Dairan Zhou Wei Shu Tingting Zhao Weijun Fang |
| author_sort | Hanyuan Zhang |
| collection | DOAJ |
| description | Developing drug delivery nanosystems with both anticancer and antibacterial effects is of great clinical value. Herein, we report a facile approach to synthesize Ag and quaternary ammonium salt (QAS) co-decorated mesoporous silica nanoparticles (MSNs), namely, Ag/QAS-MSNs, for synergistic treatment of cancer and bacterial infections. In vitro studies demonstrated that Ag/QAS-MSNs not only had a strong antibacterial activity against the bacterial pathogens but also could efficiently induce cancer cell death through an apoptotic pathway. Moreover, in vivo combination therapy with Ag and QAS in Ag/QAS-MSNs was also tested in a nude mouse tumor model, and a significant synergistic anticancer effect, which is superior to that obtained by therapy with Ag-MSNs or QAS-MSNs alone, was achieved. Such excellent anticancer and antibacterial activity of Ag/QAS-MSNs could be attributed to the synergistic effect of Ag ions and QAS. Thus, Ag/QAS-MSNs have a promising future as potent anticancer agents with high antibacterial performance. |
| first_indexed | 2024-12-10T10:26:35Z |
| format | Article |
| id | doaj.art-5302dce3cbfe477dbee77c21de35a2e2 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-10T10:26:35Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-5302dce3cbfe477dbee77c21de35a2e22022-12-22T01:52:41ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-07-011010.3389/fbioe.2022.875317875317One-Pot Synthesis of Ag/Quaternary Ammonium Salt Co-Decorated Mesoporous Silica Nanoparticles for Synergistic Treatment of Cancer and Bacterial InfectionsHanyuan Zhang0Jianxiang Xu1Xu Zhang2Teng Wang3Dairan Zhou4Wei Shu5Tingting Zhao6Weijun Fang7Department of Orthopedics, Department of Sports Medicine and Arthroscopic Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaSchool of Basic Medical Sciences, Anhui Medical University, Hefei, ChinaSchool of Basic Medical Sciences, Anhui Medical University, Hefei, ChinaSchool of Basic Medical Sciences, Anhui Medical University, Hefei, ChinaSchool of Basic Medical Sciences, Anhui Medical University, Hefei, ChinaSchool of Basic Medical Sciences, Anhui Medical University, Hefei, ChinaSchool of Basic Medical Sciences, Anhui Medical University, Hefei, ChinaSchool of Basic Medical Sciences, Anhui Medical University, Hefei, ChinaDeveloping drug delivery nanosystems with both anticancer and antibacterial effects is of great clinical value. Herein, we report a facile approach to synthesize Ag and quaternary ammonium salt (QAS) co-decorated mesoporous silica nanoparticles (MSNs), namely, Ag/QAS-MSNs, for synergistic treatment of cancer and bacterial infections. In vitro studies demonstrated that Ag/QAS-MSNs not only had a strong antibacterial activity against the bacterial pathogens but also could efficiently induce cancer cell death through an apoptotic pathway. Moreover, in vivo combination therapy with Ag and QAS in Ag/QAS-MSNs was also tested in a nude mouse tumor model, and a significant synergistic anticancer effect, which is superior to that obtained by therapy with Ag-MSNs or QAS-MSNs alone, was achieved. Such excellent anticancer and antibacterial activity of Ag/QAS-MSNs could be attributed to the synergistic effect of Ag ions and QAS. Thus, Ag/QAS-MSNs have a promising future as potent anticancer agents with high antibacterial performance.https://www.frontiersin.org/articles/10.3389/fbioe.2022.875317/fullsynergistic treatmentanticancerantibacterial activitymesoporous silica nanoparticlesquaternary ammonium saltsAg |
| spellingShingle | Hanyuan Zhang Jianxiang Xu Xu Zhang Teng Wang Dairan Zhou Wei Shu Tingting Zhao Weijun Fang One-Pot Synthesis of Ag/Quaternary Ammonium Salt Co-Decorated Mesoporous Silica Nanoparticles for Synergistic Treatment of Cancer and Bacterial Infections Frontiers in Bioengineering and Biotechnology synergistic treatment anticancer antibacterial activity mesoporous silica nanoparticles quaternary ammonium salts Ag |
| title | One-Pot Synthesis of Ag/Quaternary Ammonium Salt Co-Decorated Mesoporous Silica Nanoparticles for Synergistic Treatment of Cancer and Bacterial Infections |
| title_full | One-Pot Synthesis of Ag/Quaternary Ammonium Salt Co-Decorated Mesoporous Silica Nanoparticles for Synergistic Treatment of Cancer and Bacterial Infections |
| title_fullStr | One-Pot Synthesis of Ag/Quaternary Ammonium Salt Co-Decorated Mesoporous Silica Nanoparticles for Synergistic Treatment of Cancer and Bacterial Infections |
| title_full_unstemmed | One-Pot Synthesis of Ag/Quaternary Ammonium Salt Co-Decorated Mesoporous Silica Nanoparticles for Synergistic Treatment of Cancer and Bacterial Infections |
| title_short | One-Pot Synthesis of Ag/Quaternary Ammonium Salt Co-Decorated Mesoporous Silica Nanoparticles for Synergistic Treatment of Cancer and Bacterial Infections |
| title_sort | one pot synthesis of ag quaternary ammonium salt co decorated mesoporous silica nanoparticles for synergistic treatment of cancer and bacterial infections |
| topic | synergistic treatment anticancer antibacterial activity mesoporous silica nanoparticles quaternary ammonium salts Ag |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.875317/full |
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