TIM-3 shuttled by MV3 cells-secreted exosomes inhibits CD4+ T cell immune function and induces macrophage M2 polarization to promote the growth and metastasis of melanoma cells

TIM-3 shuttled by MV3 cells-secreted exosomes inhibits CD4+ T cell immune function and induces macrophage M2 polarization to promote the growth and metastasis of melanoma cells

This study is sought to determine the physiological mechanisms by which exosomes-encapsulated TIM-3 derived from melanoma cells might mediate CD4+ T cell immune function and macrophage M2 polarization in melanoma. Initially, exosomes were isolated from the human skin-derived melanoma cell line MV3fo...

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Bibliographic Details
Main Authors: Xinghui Li, Yu Liu, Li Yang, Yannan Jiang, Qihong Qian
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:Translational Oncology
Subjects:
Mv3 cells
Exosomes
Tim-3
Melanoma
Cd4+ t cell immune function
Macrophage m2 polarization
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523321003259

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