Manipulation of nuclear architecture through CRISPR-mediated chromosomal looping
Chromatin looping plays an important role in gene regulation and the ability to manipulate loops would aid in understanding how this occurs. Here the authors present CLOuD9, a system that uses dimerized Cas9 complexes to selectively and reversibly establish chromatin loops.
Bibliographic Details
| Main Authors: |
Stefanie L. Morgan,
Natasha C. Mariano,
Abel Bermudez,
Nicole L. Arruda,
Fangting Wu,
Yunhai Luo,
Gautam Shankar,
Lin Jia,
Huiling Chen,
Ji-Fan Hu,
Andrew R. Hoffman,
Chiao-Chain Huang,
Sharon J. Pitteri,
Kevin C. Wang |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2017-07-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms15993
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