The Immunogenicity and Anti-tumor Efficacy of a Rationally Designed Neoantigen Vaccine for B16F10 Mouse Melanoma

The Immunogenicity and Anti-tumor Efficacy of a Rationally Designed Neoantigen Vaccine for B16F10 Mouse Melanoma

Tumor neoantigens are ideal targets for cancer immunotherapy as they are recognized by host immune system as foreigners and can elicit tumor-specific immune responses. However, existing strategies utilizing RNA or long peptides for the neoantigen vaccines render limited immune responses since only 2...

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Bibliographic Details
Main Authors: Yan Zhang, Zhibing Lin, Yuhua Wan, Huaman Cai, Li Deng, Rongxiu Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
cancer vaccine
immune response
tumor neoantigen
B16F10 melanoma
helper T cell
cytotoxic T lymphocytes
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02472/full

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