Gallium and gallium compounds: New insights into the “Trojan horse” strategy in medical applications
Infection, inflammation, tumors, and other illnesses have for a long time posed a major danger to human health and have developed into a global public health issue. However, the existing treatment methods are sometimes not effective, leading to high mortality. Therefore, it is urgent to seek new alt...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-03-01
|
| Series: | Materials & Design |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127523001193 |
| _version_ | 1797853982444486656 |
|---|---|
| author | Wenyue Sun Manlin Qi Shi Cheng Chunyan Li Biao Dong Lin Wang |
| author_facet | Wenyue Sun Manlin Qi Shi Cheng Chunyan Li Biao Dong Lin Wang |
| author_sort | Wenyue Sun |
| collection | DOAJ |
| description | Infection, inflammation, tumors, and other illnesses have for a long time posed a major danger to human health and have developed into a global public health issue. However, the existing treatment methods are sometimes not effective, leading to high mortality. Therefore, it is urgent to seek new alternative therapies. Gallium and related derivatives have received a lot of interest recently because of their exceptional biological safety and distinctive pharmacological properties. More crucially, gallium and its compounds have the potential to specifically destroy iron metabolism, called the “Trojan Horse” strategy, which provides unparalleled opportunities in antibacterial, anti-tumor, and bone regeneration. In this review, gallium and its compounds-based biomedical applications in antibacterial, anti-tumor, anti-inflammatory, and bone regeneration are focused upon and the relevant therapeutic mechanisms are discussed. Then, the latest gallium-based drug design and drug delivery system are summarized. Finally, we put forward the limitations of current gallium materials and the development trend of future materials. This review is anticipated to offer new insights into the treatment of gallium and its compounds, and provide new inspiration for application and design in the future. |
| first_indexed | 2024-04-09T19:58:31Z |
| format | Article |
| id | doaj.art-530c6de2787c43f0b6a7d8ef1974ae2f |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-04-09T19:58:31Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-530c6de2787c43f0b6a7d8ef1974ae2f2023-04-03T05:20:43ZengElsevierMaterials & Design0264-12752023-03-01227111704Gallium and gallium compounds: New insights into the “Trojan horse” strategy in medical applicationsWenyue Sun0Manlin Qi1Shi Cheng2Chunyan Li3Biao Dong4Lin Wang5Department of Oral Implantology, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, School of Stomatology, Jilin University, Changchun 130021, PR ChinaDepartment of Oral Implantology, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, School of Stomatology, Jilin University, Changchun 130021, PR China; Corresponding authors.Department of Oral Implantology, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, School of Stomatology, Jilin University, Changchun 130021, PR ChinaDepartment of Oral Implantology, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, School of Stomatology, Jilin University, Changchun 130021, PR ChinaState Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, PR China; Corresponding authors.Department of Oral Implantology, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, School of Stomatology, Jilin University, Changchun 130021, PR China; Corresponding authors.Infection, inflammation, tumors, and other illnesses have for a long time posed a major danger to human health and have developed into a global public health issue. However, the existing treatment methods are sometimes not effective, leading to high mortality. Therefore, it is urgent to seek new alternative therapies. Gallium and related derivatives have received a lot of interest recently because of their exceptional biological safety and distinctive pharmacological properties. More crucially, gallium and its compounds have the potential to specifically destroy iron metabolism, called the “Trojan Horse” strategy, which provides unparalleled opportunities in antibacterial, anti-tumor, and bone regeneration. In this review, gallium and its compounds-based biomedical applications in antibacterial, anti-tumor, anti-inflammatory, and bone regeneration are focused upon and the relevant therapeutic mechanisms are discussed. Then, the latest gallium-based drug design and drug delivery system are summarized. Finally, we put forward the limitations of current gallium materials and the development trend of future materials. This review is anticipated to offer new insights into the treatment of gallium and its compounds, and provide new inspiration for application and design in the future.http://www.sciencedirect.com/science/article/pii/S0264127523001193GalliumIron“Trojan horse” strategyIron metabolismDelivery system |
| spellingShingle | Wenyue Sun Manlin Qi Shi Cheng Chunyan Li Biao Dong Lin Wang Gallium and gallium compounds: New insights into the “Trojan horse” strategy in medical applications Materials & Design Gallium Iron “Trojan horse” strategy Iron metabolism Delivery system |
| title | Gallium and gallium compounds: New insights into the “Trojan horse” strategy in medical applications |
| title_full | Gallium and gallium compounds: New insights into the “Trojan horse” strategy in medical applications |
| title_fullStr | Gallium and gallium compounds: New insights into the “Trojan horse” strategy in medical applications |
| title_full_unstemmed | Gallium and gallium compounds: New insights into the “Trojan horse” strategy in medical applications |
| title_short | Gallium and gallium compounds: New insights into the “Trojan horse” strategy in medical applications |
| title_sort | gallium and gallium compounds new insights into the trojan horse strategy in medical applications |
| topic | Gallium Iron “Trojan horse” strategy Iron metabolism Delivery system |
| url | http://www.sciencedirect.com/science/article/pii/S0264127523001193 |
| work_keys_str_mv | AT wenyuesun galliumandgalliumcompoundsnewinsightsintothetrojanhorsestrategyinmedicalapplications AT manlinqi galliumandgalliumcompoundsnewinsightsintothetrojanhorsestrategyinmedicalapplications AT shicheng galliumandgalliumcompoundsnewinsightsintothetrojanhorsestrategyinmedicalapplications AT chunyanli galliumandgalliumcompoundsnewinsightsintothetrojanhorsestrategyinmedicalapplications AT biaodong galliumandgalliumcompoundsnewinsightsintothetrojanhorsestrategyinmedicalapplications AT linwang galliumandgalliumcompoundsnewinsightsintothetrojanhorsestrategyinmedicalapplications |