Regenerative Therapy for Corneal Scarring Disorders
The cornea is a transparent and vitally multifaceted component of the eye, playing a pivotal role in vision and ocular health. It has primary refractive and protective functions. Typical corneal dysfunctions include opacities and deformities that result from injuries, infections, or other medical co...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/12/3/649 |
| _version_ | 1797241927992606720 |
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| author | Christine Chandran Mithun Santra Elizabeth Rubin Moira L. Geary Gary Hin-Fai Yam |
| author_facet | Christine Chandran Mithun Santra Elizabeth Rubin Moira L. Geary Gary Hin-Fai Yam |
| author_sort | Christine Chandran |
| collection | DOAJ |
| description | The cornea is a transparent and vitally multifaceted component of the eye, playing a pivotal role in vision and ocular health. It has primary refractive and protective functions. Typical corneal dysfunctions include opacities and deformities that result from injuries, infections, or other medical conditions. These can significantly impair vision. The conventional challenges in managing corneal ailments include the limited regenerative capacity (except corneal epithelium), immune response after donor tissue transplantation, a risk of long-term graft rejection, and the global shortage of transplantable donor materials. This review delves into the intricate composition of the cornea, the landscape of corneal regeneration, and the multifaceted repercussions of scar-related pathologies. It will elucidate the etiology and types of dysfunctions, assess current treatments and their limitations, and explore the potential of regenerative therapy that has emerged in both in vivo and clinical trials. This review will shed light on existing gaps in corneal disorder management and discuss the feasibility and challenges of advancing regenerative therapies for corneal stromal scarring. |
| first_indexed | 2024-04-24T18:31:07Z |
| format | Article |
| id | doaj.art-530e59ea6faf4936863242bccaa76a9b |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-04-24T18:31:07Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-530e59ea6faf4936863242bccaa76a9b2024-03-27T13:23:02ZengMDPI AGBiomedicines2227-90592024-03-0112364910.3390/biomedicines12030649Regenerative Therapy for Corneal Scarring DisordersChristine Chandran0Mithun Santra1Elizabeth Rubin2Moira L. Geary3Gary Hin-Fai Yam4Corneal Regeneration Laboratory, Department of Ophthalmology, Mercy Vision Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USACorneal Regeneration Laboratory, Department of Ophthalmology, Mercy Vision Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USACorneal Regeneration Laboratory, Department of Ophthalmology, Mercy Vision Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USACorneal Regeneration Laboratory, Department of Ophthalmology, Mercy Vision Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USACorneal Regeneration Laboratory, Department of Ophthalmology, Mercy Vision Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USAThe cornea is a transparent and vitally multifaceted component of the eye, playing a pivotal role in vision and ocular health. It has primary refractive and protective functions. Typical corneal dysfunctions include opacities and deformities that result from injuries, infections, or other medical conditions. These can significantly impair vision. The conventional challenges in managing corneal ailments include the limited regenerative capacity (except corneal epithelium), immune response after donor tissue transplantation, a risk of long-term graft rejection, and the global shortage of transplantable donor materials. This review delves into the intricate composition of the cornea, the landscape of corneal regeneration, and the multifaceted repercussions of scar-related pathologies. It will elucidate the etiology and types of dysfunctions, assess current treatments and their limitations, and explore the potential of regenerative therapy that has emerged in both in vivo and clinical trials. This review will shed light on existing gaps in corneal disorder management and discuss the feasibility and challenges of advancing regenerative therapies for corneal stromal scarring.https://www.mdpi.com/2227-9059/12/3/649cornea scarringregenerative therapycorneal stromal cellsextracellular matrixgene therapytissue engineering |
| spellingShingle | Christine Chandran Mithun Santra Elizabeth Rubin Moira L. Geary Gary Hin-Fai Yam Regenerative Therapy for Corneal Scarring Disorders Biomedicines cornea scarring regenerative therapy corneal stromal cells extracellular matrix gene therapy tissue engineering |
| title | Regenerative Therapy for Corneal Scarring Disorders |
| title_full | Regenerative Therapy for Corneal Scarring Disorders |
| title_fullStr | Regenerative Therapy for Corneal Scarring Disorders |
| title_full_unstemmed | Regenerative Therapy for Corneal Scarring Disorders |
| title_short | Regenerative Therapy for Corneal Scarring Disorders |
| title_sort | regenerative therapy for corneal scarring disorders |
| topic | cornea scarring regenerative therapy corneal stromal cells extracellular matrix gene therapy tissue engineering |
| url | https://www.mdpi.com/2227-9059/12/3/649 |
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