PECULIARITIES OF PROGRESSING OF METABOLIC DISTURBANCES IN THE INTERRELATIONSHIP WITH THE DISBALANCE OF ADIPOCYTOKINS IN PATIENTS WITH COMBINED WITHOUT NON-ALCOHOLIC FAT LIVER OF LIVER DISEASE AND SUGAR DIABETES OF 2 TYPE
The aim of the study was to study the peculiarities of metabolic disturbances in intercourse with the imbalance of adipocytokines in patients with comorbid flow of non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (DM). In the study, 87 patients with NAFLD and type 2 diabetes (s...
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| Format: | Article |
| Language: | English |
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Scientia Publishing House
2017-04-01
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| Series: | Juvenis Scientia |
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| Online Access: | https://jscientia.org/index.php/js/article/view/73 |
| _version_ | 1818750105219497984 |
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| author | O. M. Bilovol L. R. Bobronnikova |
| author_facet | O. M. Bilovol L. R. Bobronnikova |
| author_sort | O. M. Bilovol |
| collection | DOAJ |
| description | The aim of the study was to study the peculiarities of metabolic disturbances in intercourse with the imbalance of adipocytokines in patients with comorbid flow of non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (DM). In the study, 87 patients with NAFLD and type 2 diabetes (subcomputed) participated: the first group consisted of 45 patients with combined course of NAFLD and type 2 diabetes, and the second group consisted of 42 patients with NAFLD. The control group (n = 20) was maximally comparable in age and sex to the patients being examined. The average age of the patients was 49.4 ± 5.6 years.
The body mass index in patients with combined course of NAFLD and type 2 diabetes was 1.3 times higher than that of patients with NAFLD (p<0.05). Disorders of lipid and carbohydrate metabolism were significantly more frequent in patients with concomitant course of the disease, in comparison with patients of the 2nd group (p<0.05). Patients of the 1 st group had a significant increase in the indices of systemic inflammation and adipokine retinol-binding protein-4 (RBP-4) (p<0.05), as well as a significant decrease in serum ometin compared with patients in group 2 and control group (p<0.05).
Decrease in the level of omentin and increase in serum level of RBP-4 in patients with NAFLD and type 2 diabetes should be considered as a biomarker for the formation of a metabolic syndrome and activation of the processes of fibrogenesis in the liver. |
| first_indexed | 2024-12-18T04:14:23Z |
| format | Article |
| id | doaj.art-530edbac0c5548198ea09cc697260700 |
| institution | Directory Open Access Journal |
| issn | 2414-3782 2414-3790 |
| language | English |
| last_indexed | 2024-12-18T04:14:23Z |
| publishDate | 2017-04-01 |
| publisher | Scientia Publishing House |
| record_format | Article |
| series | Juvenis Scientia |
| spelling | doaj.art-530edbac0c5548198ea09cc6972607002022-12-21T21:21:24ZengScientia Publishing HouseJuvenis Scientia2414-37822414-37902017-04-0141923PECULIARITIES OF PROGRESSING OF METABOLIC DISTURBANCES IN THE INTERRELATIONSHIP WITH THE DISBALANCE OF ADIPOCYTOKINS IN PATIENTS WITH COMBINED WITHOUT NON-ALCOHOLIC FAT LIVER OF LIVER DISEASE AND SUGAR DIABETES OF 2 TYPEO. M. Bilovol0L. R. Bobronnikova1Kharkiv National Medical UniversityKharkiv National Medical UniversityThe aim of the study was to study the peculiarities of metabolic disturbances in intercourse with the imbalance of adipocytokines in patients with comorbid flow of non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (DM). In the study, 87 patients with NAFLD and type 2 diabetes (subcomputed) participated: the first group consisted of 45 patients with combined course of NAFLD and type 2 diabetes, and the second group consisted of 42 patients with NAFLD. The control group (n = 20) was maximally comparable in age and sex to the patients being examined. The average age of the patients was 49.4 ± 5.6 years. The body mass index in patients with combined course of NAFLD and type 2 diabetes was 1.3 times higher than that of patients with NAFLD (p<0.05). Disorders of lipid and carbohydrate metabolism were significantly more frequent in patients with concomitant course of the disease, in comparison with patients of the 2nd group (p<0.05). Patients of the 1 st group had a significant increase in the indices of systemic inflammation and adipokine retinol-binding protein-4 (RBP-4) (p<0.05), as well as a significant decrease in serum ometin compared with patients in group 2 and control group (p<0.05). Decrease in the level of omentin and increase in serum level of RBP-4 in patients with NAFLD and type 2 diabetes should be considered as a biomarker for the formation of a metabolic syndrome and activation of the processes of fibrogenesis in the liver.https://jscientia.org/index.php/js/article/view/73non-alcoholic fatty liver diseasediabetes mellitus type 2metabolic disorderspathogenetic relationshipsadipocytokines |
| spellingShingle | O. M. Bilovol L. R. Bobronnikova PECULIARITIES OF PROGRESSING OF METABOLIC DISTURBANCES IN THE INTERRELATIONSHIP WITH THE DISBALANCE OF ADIPOCYTOKINS IN PATIENTS WITH COMBINED WITHOUT NON-ALCOHOLIC FAT LIVER OF LIVER DISEASE AND SUGAR DIABETES OF 2 TYPE Juvenis Scientia non-alcoholic fatty liver disease diabetes mellitus type 2 metabolic disorders pathogenetic relationships adipocytokines |
| title | PECULIARITIES OF PROGRESSING OF METABOLIC DISTURBANCES IN THE INTERRELATIONSHIP WITH THE DISBALANCE OF ADIPOCYTOKINS IN PATIENTS WITH COMBINED WITHOUT NON-ALCOHOLIC FAT LIVER OF LIVER DISEASE AND SUGAR DIABETES OF 2 TYPE |
| title_full | PECULIARITIES OF PROGRESSING OF METABOLIC DISTURBANCES IN THE INTERRELATIONSHIP WITH THE DISBALANCE OF ADIPOCYTOKINS IN PATIENTS WITH COMBINED WITHOUT NON-ALCOHOLIC FAT LIVER OF LIVER DISEASE AND SUGAR DIABETES OF 2 TYPE |
| title_fullStr | PECULIARITIES OF PROGRESSING OF METABOLIC DISTURBANCES IN THE INTERRELATIONSHIP WITH THE DISBALANCE OF ADIPOCYTOKINS IN PATIENTS WITH COMBINED WITHOUT NON-ALCOHOLIC FAT LIVER OF LIVER DISEASE AND SUGAR DIABETES OF 2 TYPE |
| title_full_unstemmed | PECULIARITIES OF PROGRESSING OF METABOLIC DISTURBANCES IN THE INTERRELATIONSHIP WITH THE DISBALANCE OF ADIPOCYTOKINS IN PATIENTS WITH COMBINED WITHOUT NON-ALCOHOLIC FAT LIVER OF LIVER DISEASE AND SUGAR DIABETES OF 2 TYPE |
| title_short | PECULIARITIES OF PROGRESSING OF METABOLIC DISTURBANCES IN THE INTERRELATIONSHIP WITH THE DISBALANCE OF ADIPOCYTOKINS IN PATIENTS WITH COMBINED WITHOUT NON-ALCOHOLIC FAT LIVER OF LIVER DISEASE AND SUGAR DIABETES OF 2 TYPE |
| title_sort | peculiarities of progressing of metabolic disturbances in the interrelationship with the disbalance of adipocytokins in patients with combined without non alcoholic fat liver of liver disease and sugar diabetes of 2 type |
| topic | non-alcoholic fatty liver disease diabetes mellitus type 2 metabolic disorders pathogenetic relationships adipocytokines |
| url | https://jscientia.org/index.php/js/article/view/73 |
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