ATP exposure stimulates glutathione efflux as a necessary switch for NLRP3 inflammasome activation

ATP exposure stimulates glutathione efflux as a necessary switch for NLRP3 inflammasome activation

The NLRP3 inflammasome is a multiprotein complex responsible for the maturation of precursor forms of interleukin (IL)-1β and IL-18 into active proinflammatory cytokines. Increasing evidence suggests that modulation of redox homeostasis contributes to the activation of the NLRP3 inflammasome. Howeve...

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Bibliographic Details
Main Authors: Tianli Zhang, Hiroyasu Tsutsuki, Waliul Islam, Katsuhiko Ono, Kohsuke Takeda, Takaaki Akaike, Tomohiro Sawa
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Redox Biology
Subjects:
NLRP3 inflammasome
Glutathione
ATP
GSH efflux
Reactive oxygen species
Redox regulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721000781

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http://www.sciencedirect.com/science/article/pii/S2213231721000781

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