Epigenetic dysregulation of secreted frizzled-related proteins in myeloproliferative neoplasms complements the JAK2V617F-mutation

Epigenetic dysregulation of secreted frizzled-related proteins in myeloproliferative neoplasms complements the JAK2V617F-mutation

<p>Abstract</p> <p>Background</p> <p>Secreted frizzled-related proteins (<it>SFRPs</it>) are antagonists of the Wnt signaling pathway, which plays a central role in stem cell maintenance and differentiation of stem cells and hematopoietic progenitors. Epigen...

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Bibliographic Details
Main Authors: Bennemann Karla, Galm Oliver, Wilop Stefan, Schubert Claudia, Brümmendorf Tim H, Jost Edgar
Format: Article
Language:English
Published: BMC 2012-08-01
Series:Clinical Epigenetics
Subjects:
DNA hypermethylation
MPN
SFRP
Tumor suppressor gene
JAK2
Online Access:http://www.clinicalepigeneticsjournal.com/content/4/1/12

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