Photoacoustic viscoelasticity assessment of prefrontal cortex and cerebellum in normal and prenatal valproic acid-exposed rats
Mechanical properties of brain tissues are from principal features from different points of view; diagnosis, the performance of the brain and neurological disorders. Particularly viscoelastic properties of the brain tissues are determinative. In this study based on a proposed accurate and non-invasi...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Photoacoustics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213597924000077 |
| _version_ | 1797300352637206528 |
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| author | Zahra Hosseindokht Shima Davoudi Mona Rahdar Mahyar Janahmadi Mohammadreza Kolahdouz Pezhman Sasanpour |
| author_facet | Zahra Hosseindokht Shima Davoudi Mona Rahdar Mahyar Janahmadi Mohammadreza Kolahdouz Pezhman Sasanpour |
| author_sort | Zahra Hosseindokht |
| collection | DOAJ |
| description | Mechanical properties of brain tissues are from principal features from different points of view; diagnosis, the performance of the brain and neurological disorders. Particularly viscoelastic properties of the brain tissues are determinative. In this study based on a proposed accurate and non-invasive method, we have measured the viscoelastic properties of prefrontal cortex and cerebellum, two important brain regions involved in motor learning and pathophysiology of autism spectrum disorder (ASD). In this regard, using photoacoustic systems, viscoelastic properties of tissues from the cerebellum and prefrontal cortex of normal and prenatal VPA (Valproic acid)-exposed (i.e. autistic-like) offspring rats are measured. Results of our study show that the cerebellums of normal tissues are stiffer than the tissue obtained from autistic-like rats, while the viscoelasticity of the prefrontal cortex of normal tissues is higher than that of autistic ones. The proposed method for the measurement of viscoelastic properties of the brain tissue has the potential not only for the fundamental studies but as a diagnosis technique. |
| first_indexed | 2024-03-07T23:06:00Z |
| format | Article |
| id | doaj.art-531412509b2a4474aa7f93dddf4daeb0 |
| institution | Directory Open Access Journal |
| issn | 2213-5979 |
| language | English |
| last_indexed | 2024-03-07T23:06:00Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photoacoustics |
| spelling | doaj.art-531412509b2a4474aa7f93dddf4daeb02024-02-22T04:52:33ZengElsevierPhotoacoustics2213-59792024-04-0136100590Photoacoustic viscoelasticity assessment of prefrontal cortex and cerebellum in normal and prenatal valproic acid-exposed ratsZahra Hosseindokht0Shima Davoudi1Mona Rahdar2Mahyar Janahmadi3Mohammadreza Kolahdouz4Pezhman Sasanpour5School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, IranDepartment of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranSchool of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran; Corresponding authors.Department of Medical Physics and Biomedical Engineering, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Corresponding authors.Mechanical properties of brain tissues are from principal features from different points of view; diagnosis, the performance of the brain and neurological disorders. Particularly viscoelastic properties of the brain tissues are determinative. In this study based on a proposed accurate and non-invasive method, we have measured the viscoelastic properties of prefrontal cortex and cerebellum, two important brain regions involved in motor learning and pathophysiology of autism spectrum disorder (ASD). In this regard, using photoacoustic systems, viscoelastic properties of tissues from the cerebellum and prefrontal cortex of normal and prenatal VPA (Valproic acid)-exposed (i.e. autistic-like) offspring rats are measured. Results of our study show that the cerebellums of normal tissues are stiffer than the tissue obtained from autistic-like rats, while the viscoelasticity of the prefrontal cortex of normal tissues is higher than that of autistic ones. The proposed method for the measurement of viscoelastic properties of the brain tissue has the potential not only for the fundamental studies but as a diagnosis technique.http://www.sciencedirect.com/science/article/pii/S2213597924000077PhotoacousticBrain TissueViscoelasticityAutismPhotoacoustic ViscoelasticityValproic acid |
| spellingShingle | Zahra Hosseindokht Shima Davoudi Mona Rahdar Mahyar Janahmadi Mohammadreza Kolahdouz Pezhman Sasanpour Photoacoustic viscoelasticity assessment of prefrontal cortex and cerebellum in normal and prenatal valproic acid-exposed rats Photoacoustics Photoacoustic Brain Tissue Viscoelasticity Autism Photoacoustic Viscoelasticity Valproic acid |
| title | Photoacoustic viscoelasticity assessment of prefrontal cortex and cerebellum in normal and prenatal valproic acid-exposed rats |
| title_full | Photoacoustic viscoelasticity assessment of prefrontal cortex and cerebellum in normal and prenatal valproic acid-exposed rats |
| title_fullStr | Photoacoustic viscoelasticity assessment of prefrontal cortex and cerebellum in normal and prenatal valproic acid-exposed rats |
| title_full_unstemmed | Photoacoustic viscoelasticity assessment of prefrontal cortex and cerebellum in normal and prenatal valproic acid-exposed rats |
| title_short | Photoacoustic viscoelasticity assessment of prefrontal cortex and cerebellum in normal and prenatal valproic acid-exposed rats |
| title_sort | photoacoustic viscoelasticity assessment of prefrontal cortex and cerebellum in normal and prenatal valproic acid exposed rats |
| topic | Photoacoustic Brain Tissue Viscoelasticity Autism Photoacoustic Viscoelasticity Valproic acid |
| url | http://www.sciencedirect.com/science/article/pii/S2213597924000077 |
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