Chemical composition and anti-inflammatory effect of Phellodendron amurense Rupr. stem bark extract
In many diseases inflammation and oxidative stress coexist and are therapeutic targets. Phellodendron amurense Rupr. has anti-inflammatory and antioxidant effects, but the mechanisms are not completely elucidated. Therefore, first P. amurense stem bark extract was analysed regarding chemical compou...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
AcademicPres
2023-09-01
|
| Series: | Notulae Botanicae Horti Agrobotanici Cluj-Napoca |
| Subjects: | |
| Online Access: | https://www.notulaebotanicae.ro/index.php/nbha/article/view/13306 |
| _version_ | 1797670711681089536 |
|---|---|
| author | Sabina-Emanuela ERHAN Alina E. PÂRVU Alexandra CIORÎȚĂ Ayu A. PUTRI Alexis J. VILLAGRANA MOLINA Marcel PÂRVU Augustin C. MOȚ |
| author_facet | Sabina-Emanuela ERHAN Alina E. PÂRVU Alexandra CIORÎȚĂ Ayu A. PUTRI Alexis J. VILLAGRANA MOLINA Marcel PÂRVU Augustin C. MOȚ |
| author_sort | Sabina-Emanuela ERHAN |
| collection | DOAJ |
| description |
In many diseases inflammation and oxidative stress coexist and are therapeutic targets. Phellodendron amurense Rupr. has anti-inflammatory and antioxidant effects, but the mechanisms are not completely elucidated. Therefore, first P. amurense stem bark extract was analysed regarding chemical compounds such as total polyphenol content (TPC), polyphenols (gallic acid, 4-hydroxybenzoic acid, caffeic acid and ferulic acid) and alkaloids (berbamine, jatrorrhizine, palmatine, and berberine). Quantitative determination of alkaloids revealed that berberine had the highest concentration of 2.44±0.22 mg/g. In vitro antioxidant activity was significant. Then, thein vivo anti-inflammatory and antioxidative effects of P. amurense extract were studied before and after acute experimental rat inflammation induction in order to find some mechanisms of these effects. The P. amurense stem bark extract had a good anti-inflammatory activity by reducing nitric oxide, 3-nitrotyrosine and NF-kB, and an antioxidant activity by lowering oxidants and increasing antioxidants. This study provides scientific knowledge and could contribute to the development of novel drugs based on P. amurense stem bark extract for the treatment of inflammatory diseases and prevention of oxidative stress.
|
| first_indexed | 2024-03-11T21:04:31Z |
| format | Article |
| id | doaj.art-5315405ed4d24d329ef44ee059f1dd58 |
| institution | Directory Open Access Journal |
| issn | 0255-965X 1842-4309 |
| language | English |
| last_indexed | 2024-03-11T21:04:31Z |
| publishDate | 2023-09-01 |
| publisher | AcademicPres |
| record_format | Article |
| series | Notulae Botanicae Horti Agrobotanici Cluj-Napoca |
| spelling | doaj.art-5315405ed4d24d329ef44ee059f1dd582023-09-29T14:37:48ZengAcademicPresNotulae Botanicae Horti Agrobotanici Cluj-Napoca0255-965X1842-43092023-09-0151310.15835/nbha51313306Chemical composition and anti-inflammatory effect of Phellodendron amurense Rupr. stem bark extractSabina-Emanuela ERHAN0Alina E. PÂRVU1Alexandra CIORÎȚĂ2Ayu A. PUTRI3Alexis J. VILLAGRANA MOLINA4Marcel PÂRVU5Augustin C. MOȚ6Babes-Bolyai University, Faculty of Biology and Geology, M. Koganiceanu Street 1, Cluj-Napoca 400084; Babeș-Bolyai University, Doctoral School of Integrative Biology, Republicii Street 44, Cluj-Napoca 400015; National Institute for Research and Development of Isotopic and Molecular Technologies, Donath Street 67-103, Cluj-Napoca 400293Iuliu Hatieganu University of Medicine and Pharmacy, Department of Pathophysiology, Victor Babes Street 4, Cluj-Napoca 400012Babes-Bolyai University, Faculty of Biology and Geology, M. Koganiceanu Street 1, Cluj-Napoca 400084Universitas Airlangga, Faculty of Medicine, Jl. Mayjen Prof. Dr. Moestopo Street 47, Surabaya 60131Autonomous University of Zacatecas, Academic Unit of Human Medicine and Health Sciences, Carretera a Guadalajara KM. 6, Zacatecas, Ejido la Escondida S/N 98160Babes-Bolyai University, Faculty of Biology and Geology, M. Koganiceanu Street 1, Cluj-Napoca 400084; Babeș-Bolyai University, Doctoral School of Integrative Biology, Republicii Street 44, Cluj-Napoca 400015Babes-Bolyai University, Faculty of Chemistry and Chemical Engineering, Arany Janos Street 11, Cluj-Napoca 400028 In many diseases inflammation and oxidative stress coexist and are therapeutic targets. Phellodendron amurense Rupr. has anti-inflammatory and antioxidant effects, but the mechanisms are not completely elucidated. Therefore, first P. amurense stem bark extract was analysed regarding chemical compounds such as total polyphenol content (TPC), polyphenols (gallic acid, 4-hydroxybenzoic acid, caffeic acid and ferulic acid) and alkaloids (berbamine, jatrorrhizine, palmatine, and berberine). Quantitative determination of alkaloids revealed that berberine had the highest concentration of 2.44±0.22 mg/g. In vitro antioxidant activity was significant. Then, thein vivo anti-inflammatory and antioxidative effects of P. amurense extract were studied before and after acute experimental rat inflammation induction in order to find some mechanisms of these effects. The P. amurense stem bark extract had a good anti-inflammatory activity by reducing nitric oxide, 3-nitrotyrosine and NF-kB, and an antioxidant activity by lowering oxidants and increasing antioxidants. This study provides scientific knowledge and could contribute to the development of novel drugs based on P. amurense stem bark extract for the treatment of inflammatory diseases and prevention of oxidative stress. https://www.notulaebotanicae.ro/index.php/nbha/article/view/13306alkaloidsAmur cork treeanti-inflammatoryantioxidantpolyphenols |
| spellingShingle | Sabina-Emanuela ERHAN Alina E. PÂRVU Alexandra CIORÎȚĂ Ayu A. PUTRI Alexis J. VILLAGRANA MOLINA Marcel PÂRVU Augustin C. MOȚ Chemical composition and anti-inflammatory effect of Phellodendron amurense Rupr. stem bark extract Notulae Botanicae Horti Agrobotanici Cluj-Napoca alkaloids Amur cork tree anti-inflammatory antioxidant polyphenols |
| title | Chemical composition and anti-inflammatory effect of Phellodendron amurense Rupr. stem bark extract |
| title_full | Chemical composition and anti-inflammatory effect of Phellodendron amurense Rupr. stem bark extract |
| title_fullStr | Chemical composition and anti-inflammatory effect of Phellodendron amurense Rupr. stem bark extract |
| title_full_unstemmed | Chemical composition and anti-inflammatory effect of Phellodendron amurense Rupr. stem bark extract |
| title_short | Chemical composition and anti-inflammatory effect of Phellodendron amurense Rupr. stem bark extract |
| title_sort | chemical composition and anti inflammatory effect of phellodendron amurense rupr stem bark extract |
| topic | alkaloids Amur cork tree anti-inflammatory antioxidant polyphenols |
| url | https://www.notulaebotanicae.ro/index.php/nbha/article/view/13306 |
| work_keys_str_mv | AT sabinaemanuelaerhan chemicalcompositionandantiinflammatoryeffectofphellodendronamurenseruprstembarkextract AT alinaeparvu chemicalcompositionandantiinflammatoryeffectofphellodendronamurenseruprstembarkextract AT alexandraciorita chemicalcompositionandantiinflammatoryeffectofphellodendronamurenseruprstembarkextract AT ayuaputri chemicalcompositionandantiinflammatoryeffectofphellodendronamurenseruprstembarkextract AT alexisjvillagranamolina chemicalcompositionandantiinflammatoryeffectofphellodendronamurenseruprstembarkextract AT marcelparvu chemicalcompositionandantiinflammatoryeffectofphellodendronamurenseruprstembarkextract AT augustincmot chemicalcompositionandantiinflammatoryeffectofphellodendronamurenseruprstembarkextract |