Apoptosis regulation by the tyrosine-protein kinase CSK
C-terminal Src kinase (CSK) is a cytosolic tyrosine-protein kinase with an important role in regulating critical cellular decisions, such as cellular apoptosis, survival, proliferation, cytoskeletal organization and many others. Current knowledge on the CSK mechanisms of action, regulation and funct...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.1078180/full |
| _version_ | 1811299031042752512 |
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| author | Andra Fortner Andra Fortner Alexandra Chera Alexandra Chera Antoanela Tanca Antoanela Tanca Octavian Bucur Octavian Bucur |
| author_facet | Andra Fortner Andra Fortner Alexandra Chera Alexandra Chera Antoanela Tanca Antoanela Tanca Octavian Bucur Octavian Bucur |
| author_sort | Andra Fortner |
| collection | DOAJ |
| description | C-terminal Src kinase (CSK) is a cytosolic tyrosine-protein kinase with an important role in regulating critical cellular decisions, such as cellular apoptosis, survival, proliferation, cytoskeletal organization and many others. Current knowledge on the CSK mechanisms of action, regulation and functions is still at an early stage, most of CSK’s known actions and functions being mediated by the negative regulation of the SRC family of tyrosine kinases (SFKs) through phosphorylation. As SFKs play a vital role in apoptosis, cell proliferation and survival regulation, SFK inhibition by CSK has a pro-apoptotic effect, which is mediated by the inhibition of cellular signaling cascades controlled by SFKs, such as the MAPK/ERK, STAT3 and PI3K/AKT signaling pathways. Abnormal functioning of CSK and SFK activation can lead to diseases such as cancer, cardiovascular and neurological manifestations. This review describes apoptosis regulation by CSK, CSK inhibition of the SFKs and further explores the clinical relevance of CSK in important pathologies, such as cancer, autoimmune, autoinflammatory, neurologic diseases, hypertension and HIV/AIDS. |
| first_indexed | 2024-04-13T06:29:12Z |
| format | Article |
| id | doaj.art-53196d700008430ab20b99a86763f7ef |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-13T06:29:12Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-53196d700008430ab20b99a86763f7ef2022-12-22T02:58:15ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-12-011010.3389/fcell.2022.10781801078180Apoptosis regulation by the tyrosine-protein kinase CSKAndra Fortner0Andra Fortner1Alexandra Chera2Alexandra Chera3Antoanela Tanca4Antoanela Tanca5Octavian Bucur6Octavian Bucur7Victor Babes National Institute of Pathology, Bucharest, RomaniaMedical School, Ruprecht-Karls-Universität Heidelberg, Heidelberg, GermanyVictor Babes National Institute of Pathology, Bucharest, RomaniaFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, RomaniaVictor Babes National Institute of Pathology, Bucharest, RomaniaFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, RomaniaVictor Babes National Institute of Pathology, Bucharest, RomaniaViron Molecular Medicine Institute, Boston, MA, United StatesC-terminal Src kinase (CSK) is a cytosolic tyrosine-protein kinase with an important role in regulating critical cellular decisions, such as cellular apoptosis, survival, proliferation, cytoskeletal organization and many others. Current knowledge on the CSK mechanisms of action, regulation and functions is still at an early stage, most of CSK’s known actions and functions being mediated by the negative regulation of the SRC family of tyrosine kinases (SFKs) through phosphorylation. As SFKs play a vital role in apoptosis, cell proliferation and survival regulation, SFK inhibition by CSK has a pro-apoptotic effect, which is mediated by the inhibition of cellular signaling cascades controlled by SFKs, such as the MAPK/ERK, STAT3 and PI3K/AKT signaling pathways. Abnormal functioning of CSK and SFK activation can lead to diseases such as cancer, cardiovascular and neurological manifestations. This review describes apoptosis regulation by CSK, CSK inhibition of the SFKs and further explores the clinical relevance of CSK in important pathologies, such as cancer, autoimmune, autoinflammatory, neurologic diseases, hypertension and HIV/AIDS.https://www.frontiersin.org/articles/10.3389/fcell.2022.1078180/fullapoptosisCsktyrosine-protein kinase CSKsrcSrc kinasesSFK |
| spellingShingle | Andra Fortner Andra Fortner Alexandra Chera Alexandra Chera Antoanela Tanca Antoanela Tanca Octavian Bucur Octavian Bucur Apoptosis regulation by the tyrosine-protein kinase CSK Frontiers in Cell and Developmental Biology apoptosis Csk tyrosine-protein kinase CSK src Src kinases SFK |
| title | Apoptosis regulation by the tyrosine-protein kinase CSK |
| title_full | Apoptosis regulation by the tyrosine-protein kinase CSK |
| title_fullStr | Apoptosis regulation by the tyrosine-protein kinase CSK |
| title_full_unstemmed | Apoptosis regulation by the tyrosine-protein kinase CSK |
| title_short | Apoptosis regulation by the tyrosine-protein kinase CSK |
| title_sort | apoptosis regulation by the tyrosine protein kinase csk |
| topic | apoptosis Csk tyrosine-protein kinase CSK src Src kinases SFK |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.1078180/full |
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