CSF Neurofilament light chain level predicts axonal damage in cerebral vasculitis
Abstract The rarity of primary angiitis of the central nervous system (PACNS) demands diagnostic and prognostic biomarkers. We retrospectively measured Neurofilament light chain (NFL) concentrations in cerebrospinal fluid in a severely relapsing PACNS patient at multiple time points during the cours...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-06-01
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| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.790 |
| _version_ | 1818608626853478400 |
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| author | Marc Pawlitzki Michaela Butryn Florian Kirchner Jacqueline Färber Oliver Beuing Jens Minnerup Sven G. Meuth Jens Neumann |
| author_facet | Marc Pawlitzki Michaela Butryn Florian Kirchner Jacqueline Färber Oliver Beuing Jens Minnerup Sven G. Meuth Jens Neumann |
| author_sort | Marc Pawlitzki |
| collection | DOAJ |
| description | Abstract The rarity of primary angiitis of the central nervous system (PACNS) demands diagnostic and prognostic biomarkers. We retrospectively measured Neurofilament light chain (NFL) concentrations in cerebrospinal fluid in a severely relapsing PACNS patient at multiple time points during the course of the disease. A marked increase in NFL levels preceding the onset of neuro‐axonal damage and arterial‐vessel abnormalities was observed with magnetic resonance imaging as well as with MR‐ and conventional angiography. Thus, marked elevation of NFL in PACNS seems to occur ahead of definitive radiological abnormalities and might serve as a diagnostic biomarker. |
| first_indexed | 2024-12-16T14:45:39Z |
| format | Article |
| id | doaj.art-5319f3098fdb4d85a81802f2745a7011 |
| institution | Directory Open Access Journal |
| issn | 2328-9503 |
| language | English |
| last_indexed | 2024-12-16T14:45:39Z |
| publishDate | 2019-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj.art-5319f3098fdb4d85a81802f2745a70112022-12-21T22:27:47ZengWileyAnnals of Clinical and Translational Neurology2328-95032019-06-01661134113710.1002/acn3.790CSF Neurofilament light chain level predicts axonal damage in cerebral vasculitisMarc Pawlitzki0Michaela Butryn1Florian Kirchner2Jacqueline Färber3Oliver Beuing4Jens Minnerup5Sven G. Meuth6Jens Neumann7Department of Neurology Otto‐von‐Guericke University Leipziger Straße 44 39120 Magdeburg GermanyDepartment of Neurology Otto‐von‐Guericke University Leipziger Straße 44 39120 Magdeburg GermanyDepartment of Neurology AMEOS Klinikum Bernburg Kustrenaer Str. 98 06406 Bernburg GermanyInstitute of Medical Microbiology Infection Control and Prevention Otto‐von‐Guericke University Leipziger Straße 44 39120 Magdeburg GermanyDepartment of Neuroradiology Otto‐von‐Guericke University Leipziger Straße 44 39120 Magdeburg GermanyDepartment of Neurology with Institute of Translational Neurology Albert‐Schweitzer‐Campus 1 48149 Münster GermanyDepartment of Neurology with Institute of Translational Neurology Albert‐Schweitzer‐Campus 1 48149 Münster GermanyDepartment of Neurology Otto‐von‐Guericke University Leipziger Straße 44 39120 Magdeburg GermanyAbstract The rarity of primary angiitis of the central nervous system (PACNS) demands diagnostic and prognostic biomarkers. We retrospectively measured Neurofilament light chain (NFL) concentrations in cerebrospinal fluid in a severely relapsing PACNS patient at multiple time points during the course of the disease. A marked increase in NFL levels preceding the onset of neuro‐axonal damage and arterial‐vessel abnormalities was observed with magnetic resonance imaging as well as with MR‐ and conventional angiography. Thus, marked elevation of NFL in PACNS seems to occur ahead of definitive radiological abnormalities and might serve as a diagnostic biomarker.https://doi.org/10.1002/acn3.790 |
| spellingShingle | Marc Pawlitzki Michaela Butryn Florian Kirchner Jacqueline Färber Oliver Beuing Jens Minnerup Sven G. Meuth Jens Neumann CSF Neurofilament light chain level predicts axonal damage in cerebral vasculitis Annals of Clinical and Translational Neurology |
| title | CSF Neurofilament light chain level predicts axonal damage in cerebral vasculitis |
| title_full | CSF Neurofilament light chain level predicts axonal damage in cerebral vasculitis |
| title_fullStr | CSF Neurofilament light chain level predicts axonal damage in cerebral vasculitis |
| title_full_unstemmed | CSF Neurofilament light chain level predicts axonal damage in cerebral vasculitis |
| title_short | CSF Neurofilament light chain level predicts axonal damage in cerebral vasculitis |
| title_sort | csf neurofilament light chain level predicts axonal damage in cerebral vasculitis |
| url | https://doi.org/10.1002/acn3.790 |
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