Changes in left ventricular structure and function associated with renal transplantation: a systematic review and meta‐analysis
Abstract Aims This study aimed to examine if the cardiac changes associated with uraemic cardiomyopathy are reversed by renal transplantation. Methods and results MEDLINE, Embase, OpenGrey, and the Cochrane Library databases were searched from 1950 to March 2020. The primary outcome measure was left...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-06-01
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| Series: | ESC Heart Failure |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ehf2.13283 |
| _version_ | 1797976441270304768 |
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| author | Luke C. Pickup Jonathan P. Law Ashwin Radhakrishnan Anna M. Price Charalampos Loutradis Toby O. Smith Nicola C. Edwards Richard P. Steeds Jonathan N. Townend Charles J. Ferro |
| author_facet | Luke C. Pickup Jonathan P. Law Ashwin Radhakrishnan Anna M. Price Charalampos Loutradis Toby O. Smith Nicola C. Edwards Richard P. Steeds Jonathan N. Townend Charles J. Ferro |
| author_sort | Luke C. Pickup |
| collection | DOAJ |
| description | Abstract Aims This study aimed to examine if the cardiac changes associated with uraemic cardiomyopathy are reversed by renal transplantation. Methods and results MEDLINE, Embase, OpenGrey, and the Cochrane Library databases were searched from 1950 to March 2020. The primary outcome measure was left ventricular mass index. Secondary outcome measures included left ventricular dimensions and measures of diastolic and systolic function. Studies were included if they used any imaging modality both before and after successful renal transplantation. Data were analysed through meta‐analysis approaches. Weight of evidence was assessed through the Grading of Recommendations Assessment, Development and Evaluation system. Twenty‐three studies used echocardiography, and three used cardiac magnetic resonance imaging as their imaging modality. The methodological quality of the evidence was generally poor. Four studies followed up control groups, two using cardiac magnetic resonance imaging and two using echocardiography. Meta‐analysis of these studies indicated that there was no difference in left ventricular mass index between groups following transplantation {standardized mean difference −0.07 [95% confidence interval (CI) −0.41 to 0.26]; P = 0.67}. There was also no difference observed in left ventricular ejection fraction [mean difference 0.39% (95% CI −4.09% to 4.87%); P = 0.86] or left ventricular end‐diastolic volume [standardized mean difference −0.24 (95% CI −0.94 to 0.45); P = 0.49]. Inconsistent reporting of changes in diastolic dysfunction did not allow for any meaningful analysis or interpretation. Conclusions The evidence does not support the notion that uraemic cardiomyopathy is reversible by renal transplantation. However, the evidence is limited by methodological weaknesses, which should be considered when interpreting these findings. |
| first_indexed | 2024-04-11T04:52:04Z |
| format | Article |
| id | doaj.art-531a17ce80dc4733b5aac64c49068bd5 |
| institution | Directory Open Access Journal |
| issn | 2055-5822 |
| language | English |
| last_indexed | 2024-04-11T04:52:04Z |
| publishDate | 2021-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj.art-531a17ce80dc4733b5aac64c49068bd52022-12-27T03:53:06ZengWileyESC Heart Failure2055-58222021-06-01832045205710.1002/ehf2.13283Changes in left ventricular structure and function associated with renal transplantation: a systematic review and meta‐analysisLuke C. Pickup0Jonathan P. Law1Ashwin Radhakrishnan2Anna M. Price3Charalampos Loutradis4Toby O. Smith5Nicola C. Edwards6Richard P. Steeds7Jonathan N. Townend8Charles J. Ferro9Birmingham Cardio‐Renal Group, Institute of Cardiovascular Sciences University of Birmingham Birmingham UKBirmingham Cardio‐Renal Group, Institute of Cardiovascular Sciences University of Birmingham Birmingham UKBirmingham Cardio‐Renal Group, Institute of Cardiovascular Sciences University of Birmingham Birmingham UKBirmingham Cardio‐Renal Group, Institute of Cardiovascular Sciences University of Birmingham Birmingham UKBirmingham Cardio‐Renal Group, Institute of Cardiovascular Sciences University of Birmingham Birmingham UKNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences University of Oxford Oxford UKBirmingham Cardio‐Renal Group, Institute of Cardiovascular Sciences University of Birmingham Birmingham UKBirmingham Cardio‐Renal Group, Institute of Cardiovascular Sciences University of Birmingham Birmingham UKBirmingham Cardio‐Renal Group, Institute of Cardiovascular Sciences University of Birmingham Birmingham UKBirmingham Cardio‐Renal Group, Institute of Cardiovascular Sciences University of Birmingham Birmingham UKAbstract Aims This study aimed to examine if the cardiac changes associated with uraemic cardiomyopathy are reversed by renal transplantation. Methods and results MEDLINE, Embase, OpenGrey, and the Cochrane Library databases were searched from 1950 to March 2020. The primary outcome measure was left ventricular mass index. Secondary outcome measures included left ventricular dimensions and measures of diastolic and systolic function. Studies were included if they used any imaging modality both before and after successful renal transplantation. Data were analysed through meta‐analysis approaches. Weight of evidence was assessed through the Grading of Recommendations Assessment, Development and Evaluation system. Twenty‐three studies used echocardiography, and three used cardiac magnetic resonance imaging as their imaging modality. The methodological quality of the evidence was generally poor. Four studies followed up control groups, two using cardiac magnetic resonance imaging and two using echocardiography. Meta‐analysis of these studies indicated that there was no difference in left ventricular mass index between groups following transplantation {standardized mean difference −0.07 [95% confidence interval (CI) −0.41 to 0.26]; P = 0.67}. There was also no difference observed in left ventricular ejection fraction [mean difference 0.39% (95% CI −4.09% to 4.87%); P = 0.86] or left ventricular end‐diastolic volume [standardized mean difference −0.24 (95% CI −0.94 to 0.45); P = 0.49]. Inconsistent reporting of changes in diastolic dysfunction did not allow for any meaningful analysis or interpretation. Conclusions The evidence does not support the notion that uraemic cardiomyopathy is reversible by renal transplantation. However, the evidence is limited by methodological weaknesses, which should be considered when interpreting these findings.https://doi.org/10.1002/ehf2.13283EchocardiographyMagnetic resonance imagingHeart failureMeta‐analysisKidney transplantationCardiomyopathy |
| spellingShingle | Luke C. Pickup Jonathan P. Law Ashwin Radhakrishnan Anna M. Price Charalampos Loutradis Toby O. Smith Nicola C. Edwards Richard P. Steeds Jonathan N. Townend Charles J. Ferro Changes in left ventricular structure and function associated with renal transplantation: a systematic review and meta‐analysis ESC Heart Failure Echocardiography Magnetic resonance imaging Heart failure Meta‐analysis Kidney transplantation Cardiomyopathy |
| title | Changes in left ventricular structure and function associated with renal transplantation: a systematic review and meta‐analysis |
| title_full | Changes in left ventricular structure and function associated with renal transplantation: a systematic review and meta‐analysis |
| title_fullStr | Changes in left ventricular structure and function associated with renal transplantation: a systematic review and meta‐analysis |
| title_full_unstemmed | Changes in left ventricular structure and function associated with renal transplantation: a systematic review and meta‐analysis |
| title_short | Changes in left ventricular structure and function associated with renal transplantation: a systematic review and meta‐analysis |
| title_sort | changes in left ventricular structure and function associated with renal transplantation a systematic review and meta analysis |
| topic | Echocardiography Magnetic resonance imaging Heart failure Meta‐analysis Kidney transplantation Cardiomyopathy |
| url | https://doi.org/10.1002/ehf2.13283 |
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