Heterogeneous ferroptosis susceptibility of macrophages caused by focal iron overload exacerbates rheumatoid arthritis

Heterogeneous ferroptosis susceptibility of macrophages caused by focal iron overload exacerbates rheumatoid arthritis

Focal iron overload is frequently observed in patients with rheumatoid arthritis (RA), yet its functional significance remains elusive. Herein, we report that iron deposition in lesion aggravates arthritis by inducing macrophage ferroptosis. We show that excessive iron in synovial fluid positively c...

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Bibliographic Details
Main Authors: Yan Liu, Xiqing Luo, Ye Chen, Junlong Dang, Donglan Zeng, Xinghua Guo, Weizhen Weng, Jun Zhao, Xiaoyi Shi, Jingrong Chen, Bo Dong, Shuyuan Zhong, Jianhua Ren, Yuhang Li, Julie Wang, Jingwen Zhang, Jianbo Sun, Hanshi Xu, Yan Lu, David Brand, Song Guo Zheng, Yunfeng Pan
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Redox Biology
Subjects:
Rheumatoid arthritis
Iron overload
Ferroptosis
Macrophage
GPX4
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723004093

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