RESULTS OF TREATMENT OF GLIAL BRAIN TUMORS
Objective: To improve the treatment results of patients with brain glioma of varying degrees of malignancy by improving post-operative diagnostics and surgical tactics. Methods: A retrospective analysis of 843 patients was carried out. Examined indicators of overall survival according to the degr...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Avicenna Tajik State Medical University
2017-12-01
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| Series: | Паёми Сино |
| Subjects: | |
| Online Access: | https://doi.org/10.25005/2074-0581-2017-19-4-476-481 |
| Summary: | Objective: To improve the treatment results of patients with brain glioma of varying degrees of malignancy by improving post-operative diagnostics and surgical tactics.
Methods: A retrospective analysis of 843 patients was carried out. Examined indicators of overall survival according to the degree of malignancy of neoplasms and the use of modern surgical technologies. The prospective analysis included 118 patients with brain glioma located in the functionally significant brain zones. Specified patients in addition to the standard neuroimaging study, diffusion-tensor tractography, surgical interventions used neuronavigation, microsurgical and intraoperative neurophysiological monitoring techniques.
Results: Among treated patients with brain gliomas, the 1-, 3-, 5-, and 10-years overall survival probability amounted accordingly 60.9%, 37.6%, 32.3%, and 22.7%, with median survival rates of 1.42 years, respectively. Implementation of both navigation and microsurgery technique during surgery significantly improved long-term outcomes, especially for high level malignant gliomas (p=0,005). When comparing the frequency of postoperative neurologic deficits in the main and control groups, revealed a statistically significant difference (p1 =0.049).
Conclusion: The diagnostic algorithm optimization and improvement of the surgical approach contribute to improving the results of treatment in patients with brain gliomas. |
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| ISSN: | 2074-0581 2959-6327 |