Gender Differences in Age-Related Striatal Dopamine Depletion in Parkinson’s Disease
Objective Gender differences are a well-known clinical characteristic of Parkinson’s disease (PD). In-vivo imaging studies demonstrated that women have greater striatal dopamine transporter (DAT) activity than do men, both in the normal population and in PD patients. We hypothesize that women exhibi...
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| Format: | Article |
| Language: | English |
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Korean Movement Disorder Society
2015-09-01
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| Series: | Journal of Movement Disorders |
| Subjects: | |
| Online Access: | http://e-jmd.org/upload/jmd-8-3-130.pdf |
| _version_ | 1827881455185821696 |
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| author | Jae Jung Lee Jee Hyun Ham Phil Hyu Lee Young H. Sohn |
| author_facet | Jae Jung Lee Jee Hyun Ham Phil Hyu Lee Young H. Sohn |
| author_sort | Jae Jung Lee |
| collection | DOAJ |
| description | Objective Gender differences are a well-known clinical characteristic of Parkinson’s disease (PD). In-vivo imaging studies demonstrated that women have greater striatal dopamine transporter (DAT) activity than do men, both in the normal population and in PD patients. We hypothesize that women exhibit more rapid aging-related striatal DAT reduction than do men, as the potential neuroprotective effect of estrogen wanes with age. Methods This study included 307 de novo PD patients (152 men and 155 women) who underwent DAT scans for an initial diagnostic work-up. Gender differences in age-related DAT decline were assessed in striatal sub-regions using linear regression analysis. Results Female patients exhibited greater DAT activity compared with male patients in all striatal sub-regions. The linear regression analysis revealed that age-related DAT decline was greater in the anterior and posterior caudate, and the anterior putamen in women compared with men; we did not observe this difference in other sub-regions. Conclusions This study demonstrated the presence of gender differences in age-related DAT decline in striatal sub-regions, particularly in the antero-dorsal striatum, in patients with PD, presumably due to aging-related decrease in estrogen. Because this difference was not observed in the sensorimotor striatum, this finding also suggests that women may not have a greater capacity to tolerate PD pathogenesis than do men. |
| first_indexed | 2024-03-12T18:37:46Z |
| format | Article |
| id | doaj.art-531d22e269264a30b5363b7d2d6d3771 |
| institution | Directory Open Access Journal |
| issn | 2005-940X 2093-4939 |
| language | English |
| last_indexed | 2024-03-12T18:37:46Z |
| publishDate | 2015-09-01 |
| publisher | Korean Movement Disorder Society |
| record_format | Article |
| series | Journal of Movement Disorders |
| spelling | doaj.art-531d22e269264a30b5363b7d2d6d37712023-08-02T07:55:37ZengKorean Movement Disorder SocietyJournal of Movement Disorders2005-940X2093-49392015-09-018313013510.14802/jmd.15031141Gender Differences in Age-Related Striatal Dopamine Depletion in Parkinson’s DiseaseJae Jung Lee0Jee Hyun Ham1Phil Hyu Lee2Young H. Sohn3 Department of Neurology, Yonsei University College of Medicine, Seoul, Korea Department of Neurology, Yonsei University College of Medicine, Seoul, Korea Department of Neurology, Yonsei University College of Medicine, Seoul, Korea Department of Neurology, Yonsei University College of Medicine, Seoul, KoreaObjective Gender differences are a well-known clinical characteristic of Parkinson’s disease (PD). In-vivo imaging studies demonstrated that women have greater striatal dopamine transporter (DAT) activity than do men, both in the normal population and in PD patients. We hypothesize that women exhibit more rapid aging-related striatal DAT reduction than do men, as the potential neuroprotective effect of estrogen wanes with age. Methods This study included 307 de novo PD patients (152 men and 155 women) who underwent DAT scans for an initial diagnostic work-up. Gender differences in age-related DAT decline were assessed in striatal sub-regions using linear regression analysis. Results Female patients exhibited greater DAT activity compared with male patients in all striatal sub-regions. The linear regression analysis revealed that age-related DAT decline was greater in the anterior and posterior caudate, and the anterior putamen in women compared with men; we did not observe this difference in other sub-regions. Conclusions This study demonstrated the presence of gender differences in age-related DAT decline in striatal sub-regions, particularly in the antero-dorsal striatum, in patients with PD, presumably due to aging-related decrease in estrogen. Because this difference was not observed in the sensorimotor striatum, this finding also suggests that women may not have a greater capacity to tolerate PD pathogenesis than do men.http://e-jmd.org/upload/jmd-8-3-130.pdfParkinson’s diseaseGenderDopamine transporter activityPETStriatum |
| spellingShingle | Jae Jung Lee Jee Hyun Ham Phil Hyu Lee Young H. Sohn Gender Differences in Age-Related Striatal Dopamine Depletion in Parkinson’s Disease Journal of Movement Disorders Parkinson’s disease Gender Dopamine transporter activity PET Striatum |
| title | Gender Differences in Age-Related Striatal Dopamine Depletion in Parkinson’s Disease |
| title_full | Gender Differences in Age-Related Striatal Dopamine Depletion in Parkinson’s Disease |
| title_fullStr | Gender Differences in Age-Related Striatal Dopamine Depletion in Parkinson’s Disease |
| title_full_unstemmed | Gender Differences in Age-Related Striatal Dopamine Depletion in Parkinson’s Disease |
| title_short | Gender Differences in Age-Related Striatal Dopamine Depletion in Parkinson’s Disease |
| title_sort | gender differences in age related striatal dopamine depletion in parkinson s disease |
| topic | Parkinson’s disease Gender Dopamine transporter activity PET Striatum |
| url | http://e-jmd.org/upload/jmd-8-3-130.pdf |
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