Effect of season and diet on heart rate and blood pressure in female red deer (Cervus elaphus) anaesthetised with medetomidine-tiletamine-zolazepam
Temperate zone ungulates like red deer (Cervus elaphus) show pronounced seasonal acclimatisation. Hypometabolism during winter is associated with cardiovascular changes, including a reduction in heart rate (fH) and temporal peripheral vasoconstriction. How anaesthesia with vasoactive substances such...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173613/?tool=EBI |
| _version_ | 1811248128011010048 |
|---|---|
| author | Hanna Rauch Friederike Pohlin Joy Einwaller Manuela Habe Kristina Gasch Anna Haw Walter Arnold Gabrielle Stalder Johanna Painer |
| author_facet | Hanna Rauch Friederike Pohlin Joy Einwaller Manuela Habe Kristina Gasch Anna Haw Walter Arnold Gabrielle Stalder Johanna Painer |
| author_sort | Hanna Rauch |
| collection | DOAJ |
| description | Temperate zone ungulates like red deer (Cervus elaphus) show pronounced seasonal acclimatisation. Hypometabolism during winter is associated with cardiovascular changes, including a reduction in heart rate (fH) and temporal peripheral vasoconstriction. How anaesthesia with vasoactive substances such as medetomidine affect the seasonally acclimatised cardiovascular system is not yet known. We anaesthetised eleven healthy female red deer with medetomidine (0.1 mg/kg) and tiletamine/zolazepam (3 mg/kg) twice in winter (ad libitum and restricted feed) and in summer (ad libitum and restricted feed), with a two-week washout-period in-between, to test for the effect of season, food availability and supplementation with omega-3 or omega-6 polyunsaturated fatty acid (PUFA) on fH and arterial blood pressure (ABP) during anaesthesia. Six animals received pellets enriched with omega-6 fatty acids (FA), and five animals with omega-3 FA. Anaesthesia significantly decreased fH in summer but not in winter and ABP was lower in winter (p < 0.05). The combination of omega-6 FA enriched pellets and food restriction resulted in a lower fH and higher ABP during anaesthesia with more pronounced changes in winter (p < 0.001). Our results demonstrate that season, food availability and type of PUFA supplementation in red deer affect the cardiovascular system during anaesthesia. |
| first_indexed | 2024-04-12T15:22:42Z |
| format | Article |
| id | doaj.art-531d24853a4a49839c130be74fd4581a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T15:22:42Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-531d24853a4a49839c130be74fd4581a2022-12-22T03:27:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01176Effect of season and diet on heart rate and blood pressure in female red deer (Cervus elaphus) anaesthetised with medetomidine-tiletamine-zolazepamHanna RauchFriederike PohlinJoy EinwallerManuela HabeKristina GaschAnna HawWalter ArnoldGabrielle StalderJohanna PainerTemperate zone ungulates like red deer (Cervus elaphus) show pronounced seasonal acclimatisation. Hypometabolism during winter is associated with cardiovascular changes, including a reduction in heart rate (fH) and temporal peripheral vasoconstriction. How anaesthesia with vasoactive substances such as medetomidine affect the seasonally acclimatised cardiovascular system is not yet known. We anaesthetised eleven healthy female red deer with medetomidine (0.1 mg/kg) and tiletamine/zolazepam (3 mg/kg) twice in winter (ad libitum and restricted feed) and in summer (ad libitum and restricted feed), with a two-week washout-period in-between, to test for the effect of season, food availability and supplementation with omega-3 or omega-6 polyunsaturated fatty acid (PUFA) on fH and arterial blood pressure (ABP) during anaesthesia. Six animals received pellets enriched with omega-6 fatty acids (FA), and five animals with omega-3 FA. Anaesthesia significantly decreased fH in summer but not in winter and ABP was lower in winter (p < 0.05). The combination of omega-6 FA enriched pellets and food restriction resulted in a lower fH and higher ABP during anaesthesia with more pronounced changes in winter (p < 0.001). Our results demonstrate that season, food availability and type of PUFA supplementation in red deer affect the cardiovascular system during anaesthesia.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173613/?tool=EBI |
| spellingShingle | Hanna Rauch Friederike Pohlin Joy Einwaller Manuela Habe Kristina Gasch Anna Haw Walter Arnold Gabrielle Stalder Johanna Painer Effect of season and diet on heart rate and blood pressure in female red deer (Cervus elaphus) anaesthetised with medetomidine-tiletamine-zolazepam PLoS ONE |
| title | Effect of season and diet on heart rate and blood pressure in female red deer (Cervus elaphus) anaesthetised with medetomidine-tiletamine-zolazepam |
| title_full | Effect of season and diet on heart rate and blood pressure in female red deer (Cervus elaphus) anaesthetised with medetomidine-tiletamine-zolazepam |
| title_fullStr | Effect of season and diet on heart rate and blood pressure in female red deer (Cervus elaphus) anaesthetised with medetomidine-tiletamine-zolazepam |
| title_full_unstemmed | Effect of season and diet on heart rate and blood pressure in female red deer (Cervus elaphus) anaesthetised with medetomidine-tiletamine-zolazepam |
| title_short | Effect of season and diet on heart rate and blood pressure in female red deer (Cervus elaphus) anaesthetised with medetomidine-tiletamine-zolazepam |
| title_sort | effect of season and diet on heart rate and blood pressure in female red deer cervus elaphus anaesthetised with medetomidine tiletamine zolazepam |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173613/?tool=EBI |
| work_keys_str_mv | AT hannarauch effectofseasonanddietonheartrateandbloodpressureinfemalereddeercervuselaphusanaesthetisedwithmedetomidinetiletaminezolazepam AT friederikepohlin effectofseasonanddietonheartrateandbloodpressureinfemalereddeercervuselaphusanaesthetisedwithmedetomidinetiletaminezolazepam AT joyeinwaller effectofseasonanddietonheartrateandbloodpressureinfemalereddeercervuselaphusanaesthetisedwithmedetomidinetiletaminezolazepam AT manuelahabe effectofseasonanddietonheartrateandbloodpressureinfemalereddeercervuselaphusanaesthetisedwithmedetomidinetiletaminezolazepam AT kristinagasch effectofseasonanddietonheartrateandbloodpressureinfemalereddeercervuselaphusanaesthetisedwithmedetomidinetiletaminezolazepam AT annahaw effectofseasonanddietonheartrateandbloodpressureinfemalereddeercervuselaphusanaesthetisedwithmedetomidinetiletaminezolazepam AT walterarnold effectofseasonanddietonheartrateandbloodpressureinfemalereddeercervuselaphusanaesthetisedwithmedetomidinetiletaminezolazepam AT gabriellestalder effectofseasonanddietonheartrateandbloodpressureinfemalereddeercervuselaphusanaesthetisedwithmedetomidinetiletaminezolazepam AT johannapainer effectofseasonanddietonheartrateandbloodpressureinfemalereddeercervuselaphusanaesthetisedwithmedetomidinetiletaminezolazepam |