Potential ovarian toxicity and infertility risk following targeted anti-cancer therapies
Unlike traditional chemotherapy agents which are generally cytotoxic to all cells, targeted anti-cancer therapies are designed to specifically target proliferation mechanisms in cancer cells but spare normal cells, resulting in high potency and reduced toxicity. There has therefore been a rapid incr...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Bioscientifica
2022-07-01
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| Series: | Vascular Biology |
| Subjects: | |
| Online Access: | https://raf.bioscientifica.com/view/journals/raf/3/3/RAF-22-0020.xml |
| _version_ | 1818042203886321664 |
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| author | Roseanne Rosario Wanyuan Cui Richard A Anderson |
| author_facet | Roseanne Rosario Wanyuan Cui Richard A Anderson |
| author_sort | Roseanne Rosario |
| collection | DOAJ |
| description | Unlike traditional chemotherapy agents which are generally cytotoxic to all cells, targeted anti-cancer therapies are designed to specifically target proliferation mechanisms in cancer cells but spare normal cells, resulting in high potency and reduced toxicity. There has therefore been a rapid increase in their development and use in clinical settings, including in curative-intent treatment regimens. However, the targets of some of these drugs including kinases, epigenetic regulatory proteins, DNA damage repair enzymes and proteasomes, have fundamental roles in governing normal ovarian physiology. Inhibiting their action could have significant consequences for ovarian function, with potentially long-lasting adverse effects which persist after cessation of treatment, but there is limited evidence of their effects on reproductive function. In this review, we will use literature that examines these pathways to infer the potential toxicity of targeted anti-cancer drugs on the ovary. |
| first_indexed | 2024-12-10T08:42:35Z |
| format | Article |
| id | doaj.art-531f5c2c9fb84a03bcbf814c85feb917 |
| institution | Directory Open Access Journal |
| issn | 2516-5658 |
| language | English |
| last_indexed | 2024-12-10T08:42:35Z |
| publishDate | 2022-07-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Vascular Biology |
| spelling | doaj.art-531f5c2c9fb84a03bcbf814c85feb9172022-12-22T01:55:48ZengBioscientificaVascular Biology2516-56582022-07-0133R147R162https://doi.org/10.1530/RAF-22-0020Potential ovarian toxicity and infertility risk following targeted anti-cancer therapiesRoseanne Rosario0Wanyuan Cui1Richard A Anderson2MRC Centre for Reproductive Health, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UKDepartment of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia; The Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia MRC Centre for Reproductive Health, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UKUnlike traditional chemotherapy agents which are generally cytotoxic to all cells, targeted anti-cancer therapies are designed to specifically target proliferation mechanisms in cancer cells but spare normal cells, resulting in high potency and reduced toxicity. There has therefore been a rapid increase in their development and use in clinical settings, including in curative-intent treatment regimens. However, the targets of some of these drugs including kinases, epigenetic regulatory proteins, DNA damage repair enzymes and proteasomes, have fundamental roles in governing normal ovarian physiology. Inhibiting their action could have significant consequences for ovarian function, with potentially long-lasting adverse effects which persist after cessation of treatment, but there is limited evidence of their effects on reproductive function. In this review, we will use literature that examines these pathways to infer the potential toxicity of targeted anti-cancer drugs on the ovary.https://raf.bioscientifica.com/view/journals/raf/3/3/RAF-22-0020.xmlfertility preservationovaryreproductive toxicology |
| spellingShingle | Roseanne Rosario Wanyuan Cui Richard A Anderson Potential ovarian toxicity and infertility risk following targeted anti-cancer therapies Vascular Biology fertility preservation ovary reproductive toxicology |
| title | Potential ovarian toxicity and infertility risk following targeted anti-cancer therapies |
| title_full | Potential ovarian toxicity and infertility risk following targeted anti-cancer therapies |
| title_fullStr | Potential ovarian toxicity and infertility risk following targeted anti-cancer therapies |
| title_full_unstemmed | Potential ovarian toxicity and infertility risk following targeted anti-cancer therapies |
| title_short | Potential ovarian toxicity and infertility risk following targeted anti-cancer therapies |
| title_sort | potential ovarian toxicity and infertility risk following targeted anti cancer therapies |
| topic | fertility preservation ovary reproductive toxicology |
| url | https://raf.bioscientifica.com/view/journals/raf/3/3/RAF-22-0020.xml |
| work_keys_str_mv | AT roseannerosario potentialovariantoxicityandinfertilityriskfollowingtargetedanticancertherapies AT wanyuancui potentialovariantoxicityandinfertilityriskfollowingtargetedanticancertherapies AT richardaanderson potentialovariantoxicityandinfertilityriskfollowingtargetedanticancertherapies |