The Spatiotemporal Expression of Notch1 and Numb and Their Functional Interaction during Cardiac Morphogenesis

The Spatiotemporal Expression of Notch1 and Numb and Their Functional Interaction during Cardiac Morphogenesis

Numb family proteins (NFPs), including Numb and Numblike (Numbl), are commonly known for their role as cell fate determinants for multiple types of progenitor cells, mainly due to their function as Notch inhibitors. Previous studies have shown that myocardial NFP double knockout (MDKO) hearts displa...

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Bibliographic Details
Main Authors: Lianjie Miao, Yangyang Lu, Anika Nusrat, Hala Y. Abdelnasser, Sayantap Datta, Bin Zhou, Robert J. Schwartz, Mingfu Wu
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cells
Subjects:
notch signaling
numb family proteins
cardiac progenitor cell differentiation
outflow tract
cardiomyocyte proliferation
Online Access:https://www.mdpi.com/2073-4409/10/9/2192

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