Cystoid macular edema secondary to immune recovery uveitis in a man with cytomegalovirus retinitis and AIDS
Kathir YoganathanHIV/Genito-Urinary Medicine, Abertawe Bro Morgannwg University Health Board, Singleton hospital, Swansea, UKAbstract: Cytomegalovirus (CMV) is the most common intraocular opportunistic infection in profoundly immunocompromised patients with AIDS. It is characterized by an acute, pro...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2010-09-01
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| Series: | Clinical Ophthalmology |
| Online Access: | http://www.dovepress.com/cystoid-macular-edema-secondary-to-immune-recovery-uveitis-in-a-man-wi-a5334 |
| _version_ | 1819292586241687552 |
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| author | Kathir Yoganathan |
| author_facet | Kathir Yoganathan |
| author_sort | Kathir Yoganathan |
| collection | DOAJ |
| description | Kathir YoganathanHIV/Genito-Urinary Medicine, Abertawe Bro Morgannwg University Health Board, Singleton hospital, Swansea, UKAbstract: Cytomegalovirus (CMV) is the most common intraocular opportunistic infection in profoundly immunocompromised patients with AIDS. It is characterized by an acute, progressive, necrotizing retinitis in patients with a CD4 count of <50 cells/µL. Although the incidence of CMV retinitis has declined because of the introduction of antiretroviral therapy (ART), a new syndrome of intraocular inflammation has emerged in patients with rising CD4 lymphocyte counts following ART. This is called immune recovery uveitis (IRU). It is thought to occur as a result of restored immunity to various infectious agents, commonly mycobacterial, Cryptococcus, and herpes virus infections. We report a man who was treated for CMV retinitis and later developed IRU in the form of cystoid macular edema (CMO) even though his CMV retinitis remained inactive. His CMO resolved and visual acuity improved 2 years after the onset of CMO without any treatment interventions.Keywords: HIV, cystoid macular edema, AIDS, CMV retinitis |
| first_indexed | 2024-12-24T03:56:53Z |
| format | Article |
| id | doaj.art-532107dbae404180ab3450fcdb4a91c0 |
| institution | Directory Open Access Journal |
| issn | 1177-5467 1177-5483 |
| language | English |
| last_indexed | 2024-12-24T03:56:53Z |
| publishDate | 2010-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-532107dbae404180ab3450fcdb4a91c02022-12-21T17:16:25ZengDove Medical PressClinical Ophthalmology1177-54671177-54832010-09-012010default10651067Cystoid macular edema secondary to immune recovery uveitis in a man with cytomegalovirus retinitis and AIDSKathir YoganathanKathir YoganathanHIV/Genito-Urinary Medicine, Abertawe Bro Morgannwg University Health Board, Singleton hospital, Swansea, UKAbstract: Cytomegalovirus (CMV) is the most common intraocular opportunistic infection in profoundly immunocompromised patients with AIDS. It is characterized by an acute, progressive, necrotizing retinitis in patients with a CD4 count of <50 cells/µL. Although the incidence of CMV retinitis has declined because of the introduction of antiretroviral therapy (ART), a new syndrome of intraocular inflammation has emerged in patients with rising CD4 lymphocyte counts following ART. This is called immune recovery uveitis (IRU). It is thought to occur as a result of restored immunity to various infectious agents, commonly mycobacterial, Cryptococcus, and herpes virus infections. We report a man who was treated for CMV retinitis and later developed IRU in the form of cystoid macular edema (CMO) even though his CMV retinitis remained inactive. His CMO resolved and visual acuity improved 2 years after the onset of CMO without any treatment interventions.Keywords: HIV, cystoid macular edema, AIDS, CMV retinitishttp://www.dovepress.com/cystoid-macular-edema-secondary-to-immune-recovery-uveitis-in-a-man-wi-a5334 |
| spellingShingle | Kathir Yoganathan Cystoid macular edema secondary to immune recovery uveitis in a man with cytomegalovirus retinitis and AIDS Clinical Ophthalmology |
| title | Cystoid macular edema secondary to immune recovery uveitis in a man with cytomegalovirus retinitis and AIDS |
| title_full | Cystoid macular edema secondary to immune recovery uveitis in a man with cytomegalovirus retinitis and AIDS |
| title_fullStr | Cystoid macular edema secondary to immune recovery uveitis in a man with cytomegalovirus retinitis and AIDS |
| title_full_unstemmed | Cystoid macular edema secondary to immune recovery uveitis in a man with cytomegalovirus retinitis and AIDS |
| title_short | Cystoid macular edema secondary to immune recovery uveitis in a man with cytomegalovirus retinitis and AIDS |
| title_sort | cystoid macular edema secondary to immune recovery uveitis in a man with cytomegalovirus retinitis and aids |
| url | http://www.dovepress.com/cystoid-macular-edema-secondary-to-immune-recovery-uveitis-in-a-man-wi-a5334 |
| work_keys_str_mv | AT kathiryoganathan cystoidmacularedemasecondarytoimmunerecoveryuveitisinamanwithcytomegalovirusretinitisandaids |