Assessment of Corneal Endothelium among Diabetic Patients in a Multispecialty Hospital in Tamil Nadu
Introduction: Corneal damage is the common issue affecting 70% of diabetic patients. Diabetic cornea has functional abnormalities such as decreased corneal Endothelial Cell Density (ECD), thicker corneas with increased endothelial permeability, lesser corneal sensitivity, and elevated corneal a...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2020-11-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/14177/44713_CE[Ra1]_F(KM)_PF1(AKA_KM)_GC(NS_SL)_PN(SL).pdf |
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| author | Soundaram MeenakshiSundaram Melina I Sahay Damal Kandadai Sriram Melvin George |
| author_facet | Soundaram MeenakshiSundaram Melina I Sahay Damal Kandadai Sriram Melvin George |
| author_sort | Soundaram MeenakshiSundaram |
| collection | DOAJ |
| description | Introduction: Corneal damage is the common issue affecting
70% of diabetic patients. Diabetic cornea has functional
abnormalities such as decreased corneal Endothelial Cell
Density (ECD), thicker corneas with increased endothelial
permeability, lesser corneal sensitivity, and elevated corneal
auto-fluorescence.
Aim: To study the corneal endothelial characteristics among
diabetic patients and to identify the factors associated with
endothelial damage and compare the corneal changes based
on the duration of diabetes mellitus and glycaemic control.
Materials and Methods: The hospital based cross-sectional
study was conducted in 155 patients (100 diabetic and
55 control) from 24th September 2016 to 29th March 2018. The
corneal endothelial morphological features were evaluated
using a non-contact EM-3000 specular microscope. The
morphological characteristics of endothelial cell like the ECD,
Coefficient of Variation (CV), Central Corneal Thickness (CCT),
and percentage of hexagonal cells were compared between
diabetic patients and the control population. Age, gender,
blood pressure, duration of diabetes, fasting and Postprandial
Blood Sugar (PPBS) HbA1c value, blood urea, and serum
creatinine, Intra Ocular Pressure (IOP) were also recorded, and
the endothelial cell characteristics were compared between the
diabetic groups according to the duration (< or ≥ 3 years) and
HbA1c% (< or ≥ 7%). An independent t-test was performed
to compare the means of endothelial characteristics between
study subjects and the control group and also between duration
of diabetes and HbA1C levels. A p-value of less than 0.05 was
considered statistically significant. The data were analysed
using a SPSS statistical program.
Results: Baseline characteristics like Fasting Blood Sugar
(FBS), PPBS, HbA1c, Systolic and Diastolic Blood Pressure
(SBP and DBP) were significantly higher in diabetic group than
control. A significant difference in corneal thickness (p=0.01)
and hexagonality (p<0.001) were also observed between both
the groups. The diabetic group showed a reduction in cell
density and a higher coefficient variation of cell size however
the differences were not statistically significant, There was no
significant difference in the ECD, CCT, CV, and hexagonality
irrespective to HbA1c level and duration of diabetes.
Conclusion: Patients with diabetes had a significant increase
in corneal thickness, and a higher frequency of pleomorphism
compared to control subjects. In terms of ECD and co-efficient
variation, no difference was observed between groups. |
| first_indexed | 2024-12-21T22:15:09Z |
| format | Article |
| id | doaj.art-532256ba3bcb40b39b0993b549ad1ad1 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-21T22:15:09Z |
| publishDate | 2020-11-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-532256ba3bcb40b39b0993b549ad1ad12022-12-21T18:48:29ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2020-11-011411NC01NC0410.7860/JCDR/2020/44713.14177Assessment of Corneal Endothelium among Diabetic Patients in a Multispecialty Hospital in Tamil NaduSoundaram MeenakshiSundaram0Melina I Sahay1Damal Kandadai Sriram2Melvin George3Consultant, Department of Opthalmology, Hindu Mission Hospital, Chennai, Tamil Nadu, India.Clinical Research Executive, Department of Clinical Research, Hindu Mission Hospital, Chennai, Tamil Nadu, India.Medical Director, Department of Diabetology and Endocrinology, Hindu Mission Hospital, Chennai, Tamil Nadu, India.Clinical Research Executive, Department of Clinical Research, Hindu Mission Hospital, Chennai, Tamil Nadu, India.Introduction: Corneal damage is the common issue affecting 70% of diabetic patients. Diabetic cornea has functional abnormalities such as decreased corneal Endothelial Cell Density (ECD), thicker corneas with increased endothelial permeability, lesser corneal sensitivity, and elevated corneal auto-fluorescence. Aim: To study the corneal endothelial characteristics among diabetic patients and to identify the factors associated with endothelial damage and compare the corneal changes based on the duration of diabetes mellitus and glycaemic control. Materials and Methods: The hospital based cross-sectional study was conducted in 155 patients (100 diabetic and 55 control) from 24th September 2016 to 29th March 2018. The corneal endothelial morphological features were evaluated using a non-contact EM-3000 specular microscope. The morphological characteristics of endothelial cell like the ECD, Coefficient of Variation (CV), Central Corneal Thickness (CCT), and percentage of hexagonal cells were compared between diabetic patients and the control population. Age, gender, blood pressure, duration of diabetes, fasting and Postprandial Blood Sugar (PPBS) HbA1c value, blood urea, and serum creatinine, Intra Ocular Pressure (IOP) were also recorded, and the endothelial cell characteristics were compared between the diabetic groups according to the duration (< or ≥ 3 years) and HbA1c% (< or ≥ 7%). An independent t-test was performed to compare the means of endothelial characteristics between study subjects and the control group and also between duration of diabetes and HbA1C levels. A p-value of less than 0.05 was considered statistically significant. The data were analysed using a SPSS statistical program. Results: Baseline characteristics like Fasting Blood Sugar (FBS), PPBS, HbA1c, Systolic and Diastolic Blood Pressure (SBP and DBP) were significantly higher in diabetic group than control. A significant difference in corneal thickness (p=0.01) and hexagonality (p<0.001) were also observed between both the groups. The diabetic group showed a reduction in cell density and a higher coefficient variation of cell size however the differences were not statistically significant, There was no significant difference in the ECD, CCT, CV, and hexagonality irrespective to HbA1c level and duration of diabetes. Conclusion: Patients with diabetes had a significant increase in corneal thickness, and a higher frequency of pleomorphism compared to control subjects. In terms of ECD and co-efficient variation, no difference was observed between groups.https://jcdr.net/articles/PDF/14177/44713_CE[Ra1]_F(KM)_PF1(AKA_KM)_GC(NS_SL)_PN(SL).pdfcentral corneal thicknesscorneal changesdiabetesendothelial cell density |
| spellingShingle | Soundaram MeenakshiSundaram Melina I Sahay Damal Kandadai Sriram Melvin George Assessment of Corneal Endothelium among Diabetic Patients in a Multispecialty Hospital in Tamil Nadu Journal of Clinical and Diagnostic Research central corneal thickness corneal changes diabetes endothelial cell density |
| title | Assessment of Corneal Endothelium among Diabetic Patients in a Multispecialty Hospital in Tamil Nadu |
| title_full | Assessment of Corneal Endothelium among Diabetic Patients in a Multispecialty Hospital in Tamil Nadu |
| title_fullStr | Assessment of Corneal Endothelium among Diabetic Patients in a Multispecialty Hospital in Tamil Nadu |
| title_full_unstemmed | Assessment of Corneal Endothelium among Diabetic Patients in a Multispecialty Hospital in Tamil Nadu |
| title_short | Assessment of Corneal Endothelium among Diabetic Patients in a Multispecialty Hospital in Tamil Nadu |
| title_sort | assessment of corneal endothelium among diabetic patients in a multispecialty hospital in tamil nadu |
| topic | central corneal thickness corneal changes diabetes endothelial cell density |
| url | https://jcdr.net/articles/PDF/14177/44713_CE[Ra1]_F(KM)_PF1(AKA_KM)_GC(NS_SL)_PN(SL).pdf |
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