Colorectal Cancer Screening with Computed Tomography Colonography: Single Region Experience in Kazakhstan
Background/Aims The aim of our study was to determine the efficacy of computed tomography colonography (CTC) in screening for colorectal cancer (CRC). Methods A total of 612 females and 588 males aged 45 to 75 years were enrolled in CTC screening. CTC was performed following standard bowel preparati...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Korean Society of Gastrointestinal Endoscopy
2022-01-01
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| Series: | Clinical Endoscopy |
| Subjects: | |
| Online Access: | http://e-ce.org/upload/pdf/ce-2021-066.pdf |
| _version_ | 1797669168615522304 |
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| author | Jandos Amankulov Dilyara Kaidarova Zhamilya Zholdybay Marianna Zagurovskaya Nurlan Baltabekov Madina Gabdullina Akmaral Ainakulova Dias Toleshbayev Alexandra Panina Elvira Satbayeva Zhansaya Kalieva |
| author_facet | Jandos Amankulov Dilyara Kaidarova Zhamilya Zholdybay Marianna Zagurovskaya Nurlan Baltabekov Madina Gabdullina Akmaral Ainakulova Dias Toleshbayev Alexandra Panina Elvira Satbayeva Zhansaya Kalieva |
| author_sort | Jandos Amankulov |
| collection | DOAJ |
| description | Background/Aims The aim of our study was to determine the efficacy of computed tomography colonography (CTC) in screening for colorectal cancer (CRC). Methods A total of 612 females and 588 males aged 45 to 75 years were enrolled in CTC screening. CTC was performed following standard bowel preparation and colonic insufflation with carbon dioxide. The main outcomes were the detection rate of CRC and advanced adenoma (AA), prevalence of colorectal lesions in relation to socio-demographic and health factors, and overall diagnostic performance of CTC. Results Overall, 56.5% of the 1,200 invited subjects underwent CTC screening. The sensitivity for CRC and AA was 0.89 and 0.97, respectively, while the specificity was 0.71 and 0.99, respectively. The prevalence of CRC and AA was 3.0% (18/593) and 7.1% (42/593), respectively, with the highest CRC prevalence in the 66-75 age group (≥12 times; odds ratio [OR], 12.11; 95% confidence interval [CI], 4.45-32.92). CRC and AA prevalence were inversely correlated with Asian descent, physical activity, and negative fecal immunochemical test results (OR=0.43; 95% CI, 0.22-0.83; OR=0.16; 95% CI, 0.04-0.68; OR=0.5; 95% CI, 0.07-3.85, respectively). Conclusions Our study revealed high accuracy of CTC in diagnosing colonic neoplasms, good compliance with CTC screening, and high detection rate of CRC. |
| first_indexed | 2024-03-11T20:40:13Z |
| format | Article |
| id | doaj.art-53235005352047bfa91b5a82f2622aab |
| institution | Directory Open Access Journal |
| issn | 2234-2400 2234-2443 |
| language | English |
| last_indexed | 2024-03-11T20:40:13Z |
| publishDate | 2022-01-01 |
| publisher | Korean Society of Gastrointestinal Endoscopy |
| record_format | Article |
| series | Clinical Endoscopy |
| spelling | doaj.art-53235005352047bfa91b5a82f2622aab2023-10-02T03:08:37ZengKorean Society of Gastrointestinal EndoscopyClinical Endoscopy2234-24002234-24432022-01-0155110111210.5946/ce.2021.0667558Colorectal Cancer Screening with Computed Tomography Colonography: Single Region Experience in KazakhstanJandos Amankulov0Dilyara Kaidarova1Zhamilya Zholdybay2Marianna Zagurovskaya3Nurlan Baltabekov4Madina Gabdullina5Akmaral Ainakulova6Dias Toleshbayev7Alexandra Panina8Elvira Satbayeva9Zhansaya Kalieva10 Department of Radiology and Nuclear Medicine, Kazakh Institute of Oncology and Radiology, Almaty, Kazakhstan Department of Medical Oncology, Kazakh Institute of Oncology and Radiology, Almaty, Kazakhstan Department of Visual Diagnostics, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan Department of Radiology, Medical College at the University of Kentucky, Lexington, KY, USA Department of Medical Oncology, Kazakh Institute of Oncology and Radiology, Almaty, Kazakhstan Department of Radiology and Nuclear Medicine, Kazakh Institute of Oncology and Radiology, Almaty, Kazakhstan Department of Radiology and Nuclear Medicine, Kazakh Institute of Oncology and Radiology, Almaty, Kazakhstan Department of Radiology and Nuclear Medicine, Kazakh Institute of Oncology and Radiology, Almaty, Kazakhstan Department of Radiology and Nuclear Medicine, Kazakh Institute of Oncology and Radiology, Almaty, Kazakhstan Center of Morphological Diagnostics, Kazakh Institute of Oncology and Radiology, Almaty, Kazakhstan Department of Endoscopy, Kazakh Institute of Oncology and Radiology, Almaty, KazakhstanBackground/Aims The aim of our study was to determine the efficacy of computed tomography colonography (CTC) in screening for colorectal cancer (CRC). Methods A total of 612 females and 588 males aged 45 to 75 years were enrolled in CTC screening. CTC was performed following standard bowel preparation and colonic insufflation with carbon dioxide. The main outcomes were the detection rate of CRC and advanced adenoma (AA), prevalence of colorectal lesions in relation to socio-demographic and health factors, and overall diagnostic performance of CTC. Results Overall, 56.5% of the 1,200 invited subjects underwent CTC screening. The sensitivity for CRC and AA was 0.89 and 0.97, respectively, while the specificity was 0.71 and 0.99, respectively. The prevalence of CRC and AA was 3.0% (18/593) and 7.1% (42/593), respectively, with the highest CRC prevalence in the 66-75 age group (≥12 times; odds ratio [OR], 12.11; 95% confidence interval [CI], 4.45-32.92). CRC and AA prevalence were inversely correlated with Asian descent, physical activity, and negative fecal immunochemical test results (OR=0.43; 95% CI, 0.22-0.83; OR=0.16; 95% CI, 0.04-0.68; OR=0.5; 95% CI, 0.07-3.85, respectively). Conclusions Our study revealed high accuracy of CTC in diagnosing colonic neoplasms, good compliance with CTC screening, and high detection rate of CRC.http://e-ce.org/upload/pdf/ce-2021-066.pdfcancer screeningcolonoscopycolorectal neoplasmscomputed tomography colonography |
| spellingShingle | Jandos Amankulov Dilyara Kaidarova Zhamilya Zholdybay Marianna Zagurovskaya Nurlan Baltabekov Madina Gabdullina Akmaral Ainakulova Dias Toleshbayev Alexandra Panina Elvira Satbayeva Zhansaya Kalieva Colorectal Cancer Screening with Computed Tomography Colonography: Single Region Experience in Kazakhstan Clinical Endoscopy cancer screening colonoscopy colorectal neoplasms computed tomography colonography |
| title | Colorectal Cancer Screening with Computed Tomography Colonography: Single Region Experience in Kazakhstan |
| title_full | Colorectal Cancer Screening with Computed Tomography Colonography: Single Region Experience in Kazakhstan |
| title_fullStr | Colorectal Cancer Screening with Computed Tomography Colonography: Single Region Experience in Kazakhstan |
| title_full_unstemmed | Colorectal Cancer Screening with Computed Tomography Colonography: Single Region Experience in Kazakhstan |
| title_short | Colorectal Cancer Screening with Computed Tomography Colonography: Single Region Experience in Kazakhstan |
| title_sort | colorectal cancer screening with computed tomography colonography single region experience in kazakhstan |
| topic | cancer screening colonoscopy colorectal neoplasms computed tomography colonography |
| url | http://e-ce.org/upload/pdf/ce-2021-066.pdf |
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