Association of type 1 diabetes mellitus (DM1) with polymorphous alleles of class II HLA genes in Yakutian and Russian populations
Materials and methods. HLA genotyping was accomplished in 51 DM1 patients and 51 volunteers randomly selected from the indigenous populationof Yakutia (Yakuts in three successive generations). Another 205 DM1 patients and 300 healthy subjects comprised random samples of patients andcontrols respecti...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2009-09-01
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| Series: | Сахарный диабет |
| Subjects: | |
| Online Access: | https://www.dia-endojournals.ru/jour/article/view/5448 |
| _version_ | 1797255345341464576 |
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| author | Elena Vital'evna Titovich Tamara Leonidovna Kuraeva G I Danilova L P Alekseev M N Boldyreva A N Nikitin O N Ivanova Sergey Alexandrovich Prokofiev Lyubov' Iosifovna Zilberman N M Tsitlidze Valery Vyacheslavovich Nosikov Ivan Ivanovich Dedov |
| author_facet | Elena Vital'evna Titovich Tamara Leonidovna Kuraeva G I Danilova L P Alekseev M N Boldyreva A N Nikitin O N Ivanova Sergey Alexandrovich Prokofiev Lyubov' Iosifovna Zilberman N M Tsitlidze Valery Vyacheslavovich Nosikov Ivan Ivanovich Dedov |
| author_sort | Elena Vital'evna Titovich |
| collection | DOAJ |
| description | Materials and methods. HLA genotyping was accomplished in 51 DM1 patients and 51 volunteers randomly selected from the indigenous populationof Yakutia (Yakuts in three successive generations). Another 205 DM1 patients and 300 healthy subjects comprised random samples of patients andcontrols respectively from residents of Moscow and Moscow region. Results. HLA DRB1*17(03) allele proved to be the strongest one predisposing to DM1 in the Yakutian population (relative risk, RR=8,47) andDQB1*0304 in the Moscow population (RR=8,94). The presence of DRB1*04, DRB1*17(03), DQA1*0301, DQB1*0201, and DQB1*0302 accountedfor RR >2 in both populations. Only two alleles, DRB1*04 and DRB17(03), in the Yakutian population and five of the six (DRB1*04,DRB1*17(03), DQA1*(0301), DQB1*0302, and DQB1*0304) in the Moscow one were closely associated with DM1 (RR >4). DRB1*09, DRB1*11,DQB1*13, DQB1*0602/8 in Yakutian and DRB1*11, DRB1*13, DQA1*0103, DQB1*0301, DQB1*0602/8 in Moscow populations had the highestprotective potential (RR |
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| format | Article |
| id | doaj.art-5323be91c99544c4a6a3e858d767d171 |
| institution | Directory Open Access Journal |
| issn | 2072-0351 2072-0378 |
| language | English |
| last_indexed | 2024-04-24T22:04:22Z |
| publishDate | 2009-09-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj.art-5323be91c99544c4a6a3e858d767d1712024-03-20T11:47:54ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782009-09-01123263210.14341/2072-0351-54485406Association of type 1 diabetes mellitus (DM1) with polymorphous alleles of class II HLA genes in Yakutian and Russian populationsElena Vital'evna Titovich0Tamara Leonidovna Kuraeva1G I Danilova2L P Alekseev3M N Boldyreva4A N Nikitin5O N Ivanova6Sergey Alexandrovich Prokofiev7Lyubov' Iosifovna Zilberman8N M Tsitlidze9Valery Vyacheslavovich Nosikov10Ivan Ivanovich Dedov11Endocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowNational Medical Center of Sakha RepublicInstitute of Immunology, MoscowInstitute of Immunology, MoscowState Scientific Center of Russian Federation “Gniigenetika”, MoscowEndocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowState Scientific Center of Russian Federation “Gniigenetika”, MoscowState Scientific Center of Russian Federation “Gniigenetika”, MoscowEndocrinology Research Centre, MoscowMaterials and methods. HLA genotyping was accomplished in 51 DM1 patients and 51 volunteers randomly selected from the indigenous populationof Yakutia (Yakuts in three successive generations). Another 205 DM1 patients and 300 healthy subjects comprised random samples of patients andcontrols respectively from residents of Moscow and Moscow region. Results. HLA DRB1*17(03) allele proved to be the strongest one predisposing to DM1 in the Yakutian population (relative risk, RR=8,47) andDQB1*0304 in the Moscow population (RR=8,94). The presence of DRB1*04, DRB1*17(03), DQA1*0301, DQB1*0201, and DQB1*0302 accountedfor RR >2 in both populations. Only two alleles, DRB1*04 and DRB17(03), in the Yakutian population and five of the six (DRB1*04,DRB1*17(03), DQA1*(0301), DQB1*0302, and DQB1*0304) in the Moscow one were closely associated with DM1 (RR >4). DRB1*09, DRB1*11,DQB1*13, DQB1*0602/8 in Yakutian and DRB1*11, DRB1*13, DQA1*0103, DQB1*0301, DQB1*0602/8 in Moscow populations had the highestprotective potential (RRhttps://www.dia-endojournals.ru/jour/article/view/5448type 1 diabetes mellituspolymorphism of class ii hla genespopulation studies |
| spellingShingle | Elena Vital'evna Titovich Tamara Leonidovna Kuraeva G I Danilova L P Alekseev M N Boldyreva A N Nikitin O N Ivanova Sergey Alexandrovich Prokofiev Lyubov' Iosifovna Zilberman N M Tsitlidze Valery Vyacheslavovich Nosikov Ivan Ivanovich Dedov Association of type 1 diabetes mellitus (DM1) with polymorphous alleles of class II HLA genes in Yakutian and Russian populations Сахарный диабет type 1 diabetes mellitus polymorphism of class ii hla genes population studies |
| title | Association of type 1 diabetes mellitus (DM1) with polymorphous alleles of class II HLA genes in Yakutian and Russian populations |
| title_full | Association of type 1 diabetes mellitus (DM1) with polymorphous alleles of class II HLA genes in Yakutian and Russian populations |
| title_fullStr | Association of type 1 diabetes mellitus (DM1) with polymorphous alleles of class II HLA genes in Yakutian and Russian populations |
| title_full_unstemmed | Association of type 1 diabetes mellitus (DM1) with polymorphous alleles of class II HLA genes in Yakutian and Russian populations |
| title_short | Association of type 1 diabetes mellitus (DM1) with polymorphous alleles of class II HLA genes in Yakutian and Russian populations |
| title_sort | association of type 1 diabetes mellitus dm1 with polymorphous alleles of class ii hla genes in yakutian and russian populations |
| topic | type 1 diabetes mellitus polymorphism of class ii hla genes population studies |
| url | https://www.dia-endojournals.ru/jour/article/view/5448 |
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