Ruthenium(II) dimethyl sulphoxide based complexes: A potent inducer of apoptosis
Ruthenium (Ru) Dimethylsulphoxide complexes have appeared as a prominent compound among the potential metal-based drug for the cure of cancer. Cancer is marked with the uncontrolled proliferative activity that can be treated with apoptosis inducers. Therefore, in the present study the potentials of...
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| Language: | English |
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Elsevier
2022-01-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715622002004 |
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| author | Sunita Khatkar Santosh Kumar Dubey Priyanka Saraf Jitender Kumar Bhardwaj Satish Kumar V. Kumar Gaje Singh Shayoraj |
| author_facet | Sunita Khatkar Santosh Kumar Dubey Priyanka Saraf Jitender Kumar Bhardwaj Satish Kumar V. Kumar Gaje Singh Shayoraj |
| author_sort | Sunita Khatkar |
| collection | DOAJ |
| description | Ruthenium (Ru) Dimethylsulphoxide complexes have appeared as a prominent compound among the potential metal-based drug for the cure of cancer. Cancer is marked with the uncontrolled proliferative activity that can be treated with apoptosis inducers. Therefore, in the present study the potentials of ruthenium complexes as an inducer of apoptosis evaluated through appropriate techniques. Two ruthenium (Ru) complexes of composition [Ru II(PyS)2(DMSO)2] (C1) and [RuII(mbtz)2(DMSO)2] (C2) with co-ligands (PySH: 2-mercatopyridine and mbtzH: 2- mercaptobenzothiazole) have been synthesized and examined for their apoptosis inducing activity in ovarian granulosa cells. The biological assays revealed that both the complexes induce various histomorphological, cytotoxic and genotoxic alterations characteristic of apoptosis, within granulosa cells of ovarian antral follicles. Thus suggesting the anti-apoptotic and anti-cancerous activity of ruthenium (Ru) based complexes within granulosa cells of ovarian antral follicles. To the best of our knowledge such studies are scare. |
| first_indexed | 2024-04-11T06:12:53Z |
| format | Article |
| id | doaj.art-5324026bb39c4bf8a7bde97a4126acb4 |
| institution | Directory Open Access Journal |
| issn | 2211-7156 |
| language | English |
| last_indexed | 2024-04-11T06:12:53Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj.art-5324026bb39c4bf8a7bde97a4126acb42022-12-22T04:41:09ZengElsevierResults in Chemistry2211-71562022-01-014100481Ruthenium(II) dimethyl sulphoxide based complexes: A potent inducer of apoptosisSunita Khatkar0Santosh Kumar Dubey1Priyanka Saraf2Jitender Kumar Bhardwaj3Satish Kumar4V. Kumar5Gaje Singh6 Shayoraj7Department of Chemistry, Institute of Integrated & Honors Studies, Kurukshetra University, Kurukshetra 136 119, IndiaDepartment of Chemistry, Institute of Integrated & Honors Studies, Kurukshetra University, Kurukshetra 136 119, India; Corresponding authors.Reproductive Physiology Laboratory, Department of Zoology, Kurukshetra University, Kurukshetra 136 119, IndiaReproductive Physiology Laboratory, Department of Zoology, Kurukshetra University, Kurukshetra 136 119, India; Corresponding authors.Department of Chemistry, Institute of Integrated & Honors Studies, Kurukshetra University, Kurukshetra 136 119, IndiaDepartment of Physics, Institute of Integrated & Honors Studies, Kurukshetra University, Kurukshetra 136 119, IndiaDepartment of Chemistry, Indian Institute of Technology, Ropar, Punjab 140 001, IndiaDepartment of Chemistry, Institute of Integrated & Honors Studies, Kurukshetra University, Kurukshetra 136 119, IndiaRuthenium (Ru) Dimethylsulphoxide complexes have appeared as a prominent compound among the potential metal-based drug for the cure of cancer. Cancer is marked with the uncontrolled proliferative activity that can be treated with apoptosis inducers. Therefore, in the present study the potentials of ruthenium complexes as an inducer of apoptosis evaluated through appropriate techniques. Two ruthenium (Ru) complexes of composition [Ru II(PyS)2(DMSO)2] (C1) and [RuII(mbtz)2(DMSO)2] (C2) with co-ligands (PySH: 2-mercatopyridine and mbtzH: 2- mercaptobenzothiazole) have been synthesized and examined for their apoptosis inducing activity in ovarian granulosa cells. The biological assays revealed that both the complexes induce various histomorphological, cytotoxic and genotoxic alterations characteristic of apoptosis, within granulosa cells of ovarian antral follicles. Thus suggesting the anti-apoptotic and anti-cancerous activity of ruthenium (Ru) based complexes within granulosa cells of ovarian antral follicles. To the best of our knowledge such studies are scare.http://www.sciencedirect.com/science/article/pii/S2211715622002004RuII complexesCancerGranulosa cellsApoptosis |
| spellingShingle | Sunita Khatkar Santosh Kumar Dubey Priyanka Saraf Jitender Kumar Bhardwaj Satish Kumar V. Kumar Gaje Singh Shayoraj Ruthenium(II) dimethyl sulphoxide based complexes: A potent inducer of apoptosis Results in Chemistry RuII complexes Cancer Granulosa cells Apoptosis |
| title | Ruthenium(II) dimethyl sulphoxide based complexes: A potent inducer of apoptosis |
| title_full | Ruthenium(II) dimethyl sulphoxide based complexes: A potent inducer of apoptosis |
| title_fullStr | Ruthenium(II) dimethyl sulphoxide based complexes: A potent inducer of apoptosis |
| title_full_unstemmed | Ruthenium(II) dimethyl sulphoxide based complexes: A potent inducer of apoptosis |
| title_short | Ruthenium(II) dimethyl sulphoxide based complexes: A potent inducer of apoptosis |
| title_sort | ruthenium ii dimethyl sulphoxide based complexes a potent inducer of apoptosis |
| topic | RuII complexes Cancer Granulosa cells Apoptosis |
| url | http://www.sciencedirect.com/science/article/pii/S2211715622002004 |
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