Ameliorative effect of Pergularia daemia (Forssk.) Chiov. leaves extract against anti-tuberculosis drugs induced liver injury in rats
Objective: To evaluate therapeutic potential of hydroethanolic extract of Pergularia daemia (P. daemia) against anti-tuberculosis drugs (ATDs) induced liver injury. Methods: Wistar albino rats were divided into seven groups of six animal in each. The ATDs and P. daemia extract (100, 200 and 400 mg/k...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Asian Pacific Journal of Tropical Medicine |
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| Online Access: | http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=9;spage=518;epage=525;aulast=Mishra |
| _version_ | 1819227280956719104 |
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| author | Gita Mishra Hemeshwer Kumar Chandra Nisha Sahu Satendra Kumar Nirala Monika Bhadauria |
| author_facet | Gita Mishra Hemeshwer Kumar Chandra Nisha Sahu Satendra Kumar Nirala Monika Bhadauria |
| author_sort | Gita Mishra |
| collection | DOAJ |
| description | Objective: To evaluate therapeutic potential of hydroethanolic extract of Pergularia daemia (P. daemia) against anti-tuberculosis drugs (ATDs) induced liver injury. Methods: Wistar albino rats were divided into seven groups of six animal in each. The ATDs and P. daemia extract (100, 200 and 400 mg/kg, p.o.) were conjointly administered for 8 weeks and various biochemical, histoarchitectural, ultrastructural studies were performed. Results: Administration of ATDs significantly increased aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, triglycerides, cholesterol, bilirubin and decreased glucose and albumin level. Increased lipid peroxidation and reduction in glutathione, superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glucose-6-phosphate dehydrogenase were found after ATDs exposure. Administration of P. daemia extract maintained serum biochemical indices as well as antioxidant status similar to control and diminished oxidative stress in dose dependent manner. Histological and ultra-structural observations substantiated biochemical findings. Conclusions: P. daemia has therapeutic potential against ATDs induced liver injury and may be of clinical significance after extensive studies. |
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| id | doaj.art-5327d2dc3aeb4af6adb52d4f37bb993e |
| institution | Directory Open Access Journal |
| issn | 2352-4146 |
| language | English |
| last_indexed | 2024-12-23T10:38:53Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Tropical Medicine |
| spelling | doaj.art-5327d2dc3aeb4af6adb52d4f37bb993e2022-12-21T17:50:14ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Medicine2352-41462018-01-0111951852510.4103/1995-7645.242310Ameliorative effect of Pergularia daemia (Forssk.) Chiov. leaves extract against anti-tuberculosis drugs induced liver injury in ratsGita MishraHemeshwer Kumar ChandraNisha SahuSatendra Kumar NiralaMonika BhadauriaObjective: To evaluate therapeutic potential of hydroethanolic extract of Pergularia daemia (P. daemia) against anti-tuberculosis drugs (ATDs) induced liver injury. Methods: Wistar albino rats were divided into seven groups of six animal in each. The ATDs and P. daemia extract (100, 200 and 400 mg/kg, p.o.) were conjointly administered for 8 weeks and various biochemical, histoarchitectural, ultrastructural studies were performed. Results: Administration of ATDs significantly increased aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, triglycerides, cholesterol, bilirubin and decreased glucose and albumin level. Increased lipid peroxidation and reduction in glutathione, superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glucose-6-phosphate dehydrogenase were found after ATDs exposure. Administration of P. daemia extract maintained serum biochemical indices as well as antioxidant status similar to control and diminished oxidative stress in dose dependent manner. Histological and ultra-structural observations substantiated biochemical findings. Conclusions: P. daemia has therapeutic potential against ATDs induced liver injury and may be of clinical significance after extensive studies.http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=9;spage=518;epage=525;aulast=Mishraantituberculosis drugshepatic injurypergularia daemiaantioxidant activity |
| spellingShingle | Gita Mishra Hemeshwer Kumar Chandra Nisha Sahu Satendra Kumar Nirala Monika Bhadauria Ameliorative effect of Pergularia daemia (Forssk.) Chiov. leaves extract against anti-tuberculosis drugs induced liver injury in rats Asian Pacific Journal of Tropical Medicine antituberculosis drugs hepatic injury pergularia daemia antioxidant activity |
| title | Ameliorative effect of Pergularia daemia (Forssk.) Chiov. leaves extract against anti-tuberculosis drugs induced liver injury in rats |
| title_full | Ameliorative effect of Pergularia daemia (Forssk.) Chiov. leaves extract against anti-tuberculosis drugs induced liver injury in rats |
| title_fullStr | Ameliorative effect of Pergularia daemia (Forssk.) Chiov. leaves extract against anti-tuberculosis drugs induced liver injury in rats |
| title_full_unstemmed | Ameliorative effect of Pergularia daemia (Forssk.) Chiov. leaves extract against anti-tuberculosis drugs induced liver injury in rats |
| title_short | Ameliorative effect of Pergularia daemia (Forssk.) Chiov. leaves extract against anti-tuberculosis drugs induced liver injury in rats |
| title_sort | ameliorative effect of pergularia daemia forssk chiov leaves extract against anti tuberculosis drugs induced liver injury in rats |
| topic | antituberculosis drugs hepatic injury pergularia daemia antioxidant activity |
| url | http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=9;spage=518;epage=525;aulast=Mishra |
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