Animal research in cardiac arrest
The purpose of this narrative review is to provide an overview of lessons learned from experimental cardiac arrest studies, limitations, translation to clinical studies, ethical considerations and future directions.Cardiac arrest animal studies have provided valuable insights into the pathophysiolog...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-03-01
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| Series: | Resuscitation Plus |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666520423001546 |
| _version_ | 1797242948411195392 |
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| author | Lars W. Andersen Lauge Vammen Asger Granfeldt |
| author_facet | Lars W. Andersen Lauge Vammen Asger Granfeldt |
| author_sort | Lars W. Andersen |
| collection | DOAJ |
| description | The purpose of this narrative review is to provide an overview of lessons learned from experimental cardiac arrest studies, limitations, translation to clinical studies, ethical considerations and future directions.Cardiac arrest animal studies have provided valuable insights into the pathophysiology of cardiac arrest, the effects of various interventions, and the development of resuscitation techniques. However, there are limitations to animal models that should be considered when interpreting results. Systematic reviews have demonstrated that animal models rarely reflect the clinical condition seen in humans, nor the complex treatment that occurs during and after a cardiac arrest. Furthermore, animal models of cardiac arrest are at a significant risk of bias due to fundamental issues in performing and/or reporting critical methodological aspects. Conducting clinical trials targeting the management of rare cardiac arrest causes like e.g. hyperkalemia and pulmonary embolism is challenging due to the scarcity of eligible patients. For these research questions, animal models might provide the highest level of evidence and can potentially guide clinical practice.To continuously push cardiac arrest science forward, animal studies must be conducted and reported rigorously, designed to avoid bias and answer specific research questions. To ensure the continued relevance and generation of valuable new insights from animal studies, new approaches and techniques may be needed, including animal register studies, systematic reviews and multilaboratory trials. |
| first_indexed | 2024-03-09T02:12:35Z |
| format | Article |
| id | doaj.art-532889017d5b418c9ae776025febfd0b |
| institution | Directory Open Access Journal |
| issn | 2666-5204 |
| language | English |
| last_indexed | 2024-04-24T18:47:20Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Resuscitation Plus |
| spelling | doaj.art-532889017d5b418c9ae776025febfd0b2024-03-27T04:52:55ZengElsevierResuscitation Plus2666-52042024-03-0117100511Animal research in cardiac arrestLars W. Andersen0Lauge Vammen1Asger Granfeldt2Department of Anesthesiology and Intensive Care Medicine, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Denmark; Department of Anesthesiology and Intensive Care, Viborg Regional Hospital, Viborg, Denmark; Prehospital Emergency Medical Services, Central Region Denmark, DenmarkDepartment of Anesthesiology and Intensive Care Medicine, Aarhus University Hospital, Aarhus, DenmarkDepartment of Anesthesiology and Intensive Care Medicine, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Denmark; Corresponding author at: Department of Anesthesiology and Intensive Care, Aarhus University Hospital, Denmark.The purpose of this narrative review is to provide an overview of lessons learned from experimental cardiac arrest studies, limitations, translation to clinical studies, ethical considerations and future directions.Cardiac arrest animal studies have provided valuable insights into the pathophysiology of cardiac arrest, the effects of various interventions, and the development of resuscitation techniques. However, there are limitations to animal models that should be considered when interpreting results. Systematic reviews have demonstrated that animal models rarely reflect the clinical condition seen in humans, nor the complex treatment that occurs during and after a cardiac arrest. Furthermore, animal models of cardiac arrest are at a significant risk of bias due to fundamental issues in performing and/or reporting critical methodological aspects. Conducting clinical trials targeting the management of rare cardiac arrest causes like e.g. hyperkalemia and pulmonary embolism is challenging due to the scarcity of eligible patients. For these research questions, animal models might provide the highest level of evidence and can potentially guide clinical practice.To continuously push cardiac arrest science forward, animal studies must be conducted and reported rigorously, designed to avoid bias and answer specific research questions. To ensure the continued relevance and generation of valuable new insights from animal studies, new approaches and techniques may be needed, including animal register studies, systematic reviews and multilaboratory trials.http://www.sciencedirect.com/science/article/pii/S2666520423001546AnimalsCardiac arrestCardiopulmonary resuscitationPreclinicalExperimental |
| spellingShingle | Lars W. Andersen Lauge Vammen Asger Granfeldt Animal research in cardiac arrest Resuscitation Plus Animals Cardiac arrest Cardiopulmonary resuscitation Preclinical Experimental |
| title | Animal research in cardiac arrest |
| title_full | Animal research in cardiac arrest |
| title_fullStr | Animal research in cardiac arrest |
| title_full_unstemmed | Animal research in cardiac arrest |
| title_short | Animal research in cardiac arrest |
| title_sort | animal research in cardiac arrest |
| topic | Animals Cardiac arrest Cardiopulmonary resuscitation Preclinical Experimental |
| url | http://www.sciencedirect.com/science/article/pii/S2666520423001546 |
| work_keys_str_mv | AT larswandersen animalresearchincardiacarrest AT laugevammen animalresearchincardiacarrest AT asgergranfeldt animalresearchincardiacarrest |