Association of short-term blood pressure variability with cardiovascular mortality among incident hemodialysis patients
Objective: To investigate the association of short-term blood pressure variability (BPV) with cardiovascular mortality in hemodialysis (HD) patients, using a reliable index called average real variability (ARV), and to assess the factors associated with ARV in incident HD population. Methods: A tota...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-10-01
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| Series: | Renal Failure |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/0886022X.2018.1456456 |
| _version_ | 1818968738203959296 |
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| author | Yiduo Feng Ziqian Li Jing Liu Fang Sun Lijie Ma Yang Shen Yilun Zhou |
| author_facet | Yiduo Feng Ziqian Li Jing Liu Fang Sun Lijie Ma Yang Shen Yilun Zhou |
| author_sort | Yiduo Feng |
| collection | DOAJ |
| description | Objective: To investigate the association of short-term blood pressure variability (BPV) with cardiovascular mortality in hemodialysis (HD) patients, using a reliable index called average real variability (ARV), and to assess the factors associated with ARV in incident HD population. Methods: A total of 103 HD patients were recruited, with 44-h ambulatory blood pressure monitoring performed after the midweek HD session. Systolic BPV was assessed by SD, coefficient of variation (CV), and ARV, respectively. Laboratory data were obtained from blood samples before the midweek HD. All patients were followed up for 24 months. Results: According to the median of BPV indices, the comparisons between patients with the low and high values were conducted. Kaplan–Meier analysis showed the survival curves corresponding to median of SD and CV exhibit similar performance for the low and high groups (p = .647, p = .098, respectively). In contrast, patients with higher ARV had a lower survival rate than those with lower ARV (77.8% vs. 98.0%, p = .002). After adjustment for demographics and clinical factors, ARV (HR: 1.143; 95% CI: 1.022–1.279, p = .019) and high-sensitivity C-reactive protein (HR: 1.394; 95% CI: 1.025–1.363, p = .021) were associated with increased risk of cardiovascular mortality in HD patients. Age and interdialytic weight gain (IDWG) were related factors for ARV (β = 0.065, p = .005; β = 0.825, p = .003, respectively). Conclusions: Greater ARV was independently associated with increased risk of cardiovascular mortality in HD patients. Age and IDWG were independent related factors for ARV. |
| first_indexed | 2024-12-20T14:09:27Z |
| format | Article |
| id | doaj.art-532a2dfea33e442ea311586bb4a12ab2 |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-12-20T14:09:27Z |
| publishDate | 2018-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-532a2dfea33e442ea311586bb4a12ab22022-12-21T19:38:11ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492018-10-0140125926410.1080/0886022X.2018.14564561456456Association of short-term blood pressure variability with cardiovascular mortality among incident hemodialysis patientsYiduo Feng0Ziqian Li1Jing Liu2Fang Sun3Lijie Ma4Yang Shen5Yilun Zhou6Beijing Tiantan Hospital, Capital Medical UniversityPeking University First HospitalBeijing Chaoyang Hospital, Capital Medical UniversityBeijing Chaoyang Hospital, Capital Medical UniversityBeijing Chaoyang Hospital, Capital Medical UniversityBeijing Chaoyang Hospital, Capital Medical UniversityBeijing Tiantan Hospital, Capital Medical UniversityObjective: To investigate the association of short-term blood pressure variability (BPV) with cardiovascular mortality in hemodialysis (HD) patients, using a reliable index called average real variability (ARV), and to assess the factors associated with ARV in incident HD population. Methods: A total of 103 HD patients were recruited, with 44-h ambulatory blood pressure monitoring performed after the midweek HD session. Systolic BPV was assessed by SD, coefficient of variation (CV), and ARV, respectively. Laboratory data were obtained from blood samples before the midweek HD. All patients were followed up for 24 months. Results: According to the median of BPV indices, the comparisons between patients with the low and high values were conducted. Kaplan–Meier analysis showed the survival curves corresponding to median of SD and CV exhibit similar performance for the low and high groups (p = .647, p = .098, respectively). In contrast, patients with higher ARV had a lower survival rate than those with lower ARV (77.8% vs. 98.0%, p = .002). After adjustment for demographics and clinical factors, ARV (HR: 1.143; 95% CI: 1.022–1.279, p = .019) and high-sensitivity C-reactive protein (HR: 1.394; 95% CI: 1.025–1.363, p = .021) were associated with increased risk of cardiovascular mortality in HD patients. Age and interdialytic weight gain (IDWG) were related factors for ARV (β = 0.065, p = .005; β = 0.825, p = .003, respectively). Conclusions: Greater ARV was independently associated with increased risk of cardiovascular mortality in HD patients. Age and IDWG were independent related factors for ARV.http://dx.doi.org/10.1080/0886022X.2018.1456456Hemodialysisblood pressure variabilitycardiovascular mortality |
| spellingShingle | Yiduo Feng Ziqian Li Jing Liu Fang Sun Lijie Ma Yang Shen Yilun Zhou Association of short-term blood pressure variability with cardiovascular mortality among incident hemodialysis patients Renal Failure Hemodialysis blood pressure variability cardiovascular mortality |
| title | Association of short-term blood pressure variability with cardiovascular mortality among incident hemodialysis patients |
| title_full | Association of short-term blood pressure variability with cardiovascular mortality among incident hemodialysis patients |
| title_fullStr | Association of short-term blood pressure variability with cardiovascular mortality among incident hemodialysis patients |
| title_full_unstemmed | Association of short-term blood pressure variability with cardiovascular mortality among incident hemodialysis patients |
| title_short | Association of short-term blood pressure variability with cardiovascular mortality among incident hemodialysis patients |
| title_sort | association of short term blood pressure variability with cardiovascular mortality among incident hemodialysis patients |
| topic | Hemodialysis blood pressure variability cardiovascular mortality |
| url | http://dx.doi.org/10.1080/0886022X.2018.1456456 |
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