Mitochondrial Dysfunction-Associated Arrhythmogenic Substrates in Diabetes Mellitus
There is increasing evidence that diabetic cardiomyopathy increases the risk of cardiac arrhythmia and sudden cardiac death. While the detailed mechanisms remain incompletely understood, the loss of mitochondrial function, which is often observed in the heart of patients with diabetes, has emerged a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-12-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2018.01670/full |
| _version_ | 1819239303542210560 |
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| author | Jiajia Song Ruilin Yang Ruilin Yang Jing Yang Lufang Zhou |
| author_facet | Jiajia Song Ruilin Yang Ruilin Yang Jing Yang Lufang Zhou |
| author_sort | Jiajia Song |
| collection | DOAJ |
| description | There is increasing evidence that diabetic cardiomyopathy increases the risk of cardiac arrhythmia and sudden cardiac death. While the detailed mechanisms remain incompletely understood, the loss of mitochondrial function, which is often observed in the heart of patients with diabetes, has emerged as a key contributor to the arrhythmogenic substrates. In this mini review, the pathophysiology of mitochondrial dysfunction in diabetes mellitus is explored in detail, followed by descriptions of several mechanisms potentially linking mitochondria to arrhythmogenesis in the context of diabetic cardiomyopathy. |
| first_indexed | 2024-12-23T13:49:59Z |
| format | Article |
| id | doaj.art-532a929db23d440daea0d4caf18ba8dd |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-23T13:49:59Z |
| publishDate | 2018-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-532a929db23d440daea0d4caf18ba8dd2022-12-21T17:44:38ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2018-12-01910.3389/fphys.2018.01670420970Mitochondrial Dysfunction-Associated Arrhythmogenic Substrates in Diabetes MellitusJiajia Song0Ruilin Yang1Ruilin Yang2Jing Yang3Lufang Zhou4Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United StatesDivision of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United StatesKey Laboratory of Mechanism Theory and Equipment Design of Ministry of Education, Tianjin University, Tianjin, ChinaDivision of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United StatesDivision of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United StatesThere is increasing evidence that diabetic cardiomyopathy increases the risk of cardiac arrhythmia and sudden cardiac death. While the detailed mechanisms remain incompletely understood, the loss of mitochondrial function, which is often observed in the heart of patients with diabetes, has emerged as a key contributor to the arrhythmogenic substrates. In this mini review, the pathophysiology of mitochondrial dysfunction in diabetes mellitus is explored in detail, followed by descriptions of several mechanisms potentially linking mitochondria to arrhythmogenesis in the context of diabetic cardiomyopathy.https://www.frontiersin.org/article/10.3389/fphys.2018.01670/fullmitochondrial dysfunctionarrhythmogenesisfibrosisredox signalingdiabetes |
| spellingShingle | Jiajia Song Ruilin Yang Ruilin Yang Jing Yang Lufang Zhou Mitochondrial Dysfunction-Associated Arrhythmogenic Substrates in Diabetes Mellitus Frontiers in Physiology mitochondrial dysfunction arrhythmogenesis fibrosis redox signaling diabetes |
| title | Mitochondrial Dysfunction-Associated Arrhythmogenic Substrates in Diabetes Mellitus |
| title_full | Mitochondrial Dysfunction-Associated Arrhythmogenic Substrates in Diabetes Mellitus |
| title_fullStr | Mitochondrial Dysfunction-Associated Arrhythmogenic Substrates in Diabetes Mellitus |
| title_full_unstemmed | Mitochondrial Dysfunction-Associated Arrhythmogenic Substrates in Diabetes Mellitus |
| title_short | Mitochondrial Dysfunction-Associated Arrhythmogenic Substrates in Diabetes Mellitus |
| title_sort | mitochondrial dysfunction associated arrhythmogenic substrates in diabetes mellitus |
| topic | mitochondrial dysfunction arrhythmogenesis fibrosis redox signaling diabetes |
| url | https://www.frontiersin.org/article/10.3389/fphys.2018.01670/full |
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