The intra-nucleus integration of mitochondrial DNA (mtDNA)in cervical mucosa cells and its relation with c-myc expression
<p>Abstract</p> <p>Objective</p> <p>To explore the relationship between the integration of mitochondrial DNA(mtDNA) in the nuclei of cervical epithelium cells and the expression of c-myc.</p> <p>Methods</p> <p>The expression of c-myc protein was...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2008-09-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
| Online Access: | http://www.jeccr.com/content/27/1/36 |
| _version_ | 1811276693128609792 |
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| author | Xiang Jinying Xue Wenqun Chen Daozhen |
| author_facet | Xiang Jinying Xue Wenqun Chen Daozhen |
| author_sort | Xiang Jinying |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Objective</p> <p>To explore the relationship between the integration of mitochondrial DNA(mtDNA) in the nuclei of cervical epithelium cells and the expression of c-myc.</p> <p>Methods</p> <p>The expression of c-myc protein was measured by immunohistochemical test in 40 cases of the uterine cervix cancer, 30 cases of cervical intraepithelial neoplasia (CIN) and 30 cases of normal cervical epithelium; the sequence of mtDNA in the nuclei was detected by in situ hybridization technique.</p> <p>Results</p> <p>The detection rates of mtDNA in the nuclei of cervical epithelium cells were 27.5%, 13.3% and 0% in cervical carcinoma, CIN, and normal cervical epithelium respectively. The expression rate of c-myc in cervical mucoma cells was 67% in the mtDNA sequence positive group and was significantly higher than that in the negative group (36%).</p> <p>Conclusion</p> <p>The integration of mtDNA into the nuclei of cervical epithelium cells may be involved in the carcinogenesis of cervical epithelium cells and the expression of c-myc might be related to the integration of mtDNA sequence into nuclei of cervical epithelium cells.</p> |
| first_indexed | 2024-04-13T00:01:16Z |
| format | Article |
| id | doaj.art-532bcbc2cb1847f7bcef6bc0a9b7495c |
| institution | Directory Open Access Journal |
| issn | 1756-9966 |
| language | English |
| last_indexed | 2024-04-13T00:01:16Z |
| publishDate | 2008-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj.art-532bcbc2cb1847f7bcef6bc0a9b7495c2022-12-22T03:11:20ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662008-09-012713610.1186/1756-9966-27-36The intra-nucleus integration of mitochondrial DNA (mtDNA)in cervical mucosa cells and its relation with c-myc expressionXiang JinyingXue WenqunChen Daozhen<p>Abstract</p> <p>Objective</p> <p>To explore the relationship between the integration of mitochondrial DNA(mtDNA) in the nuclei of cervical epithelium cells and the expression of c-myc.</p> <p>Methods</p> <p>The expression of c-myc protein was measured by immunohistochemical test in 40 cases of the uterine cervix cancer, 30 cases of cervical intraepithelial neoplasia (CIN) and 30 cases of normal cervical epithelium; the sequence of mtDNA in the nuclei was detected by in situ hybridization technique.</p> <p>Results</p> <p>The detection rates of mtDNA in the nuclei of cervical epithelium cells were 27.5%, 13.3% and 0% in cervical carcinoma, CIN, and normal cervical epithelium respectively. The expression rate of c-myc in cervical mucoma cells was 67% in the mtDNA sequence positive group and was significantly higher than that in the negative group (36%).</p> <p>Conclusion</p> <p>The integration of mtDNA into the nuclei of cervical epithelium cells may be involved in the carcinogenesis of cervical epithelium cells and the expression of c-myc might be related to the integration of mtDNA sequence into nuclei of cervical epithelium cells.</p>http://www.jeccr.com/content/27/1/36 |
| spellingShingle | Xiang Jinying Xue Wenqun Chen Daozhen The intra-nucleus integration of mitochondrial DNA (mtDNA)in cervical mucosa cells and its relation with c-myc expression Journal of Experimental & Clinical Cancer Research |
| title | The intra-nucleus integration of mitochondrial DNA (mtDNA)in cervical mucosa cells and its relation with c-myc expression |
| title_full | The intra-nucleus integration of mitochondrial DNA (mtDNA)in cervical mucosa cells and its relation with c-myc expression |
| title_fullStr | The intra-nucleus integration of mitochondrial DNA (mtDNA)in cervical mucosa cells and its relation with c-myc expression |
| title_full_unstemmed | The intra-nucleus integration of mitochondrial DNA (mtDNA)in cervical mucosa cells and its relation with c-myc expression |
| title_short | The intra-nucleus integration of mitochondrial DNA (mtDNA)in cervical mucosa cells and its relation with c-myc expression |
| title_sort | intra nucleus integration of mitochondrial dna mtdna in cervical mucosa cells and its relation with c myc expression |
| url | http://www.jeccr.com/content/27/1/36 |
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