Meprin β metalloproteases associated with differential metabolite profiles in the plasma and urine of mice with type 1 diabetes and diabetic nephropathy

Meprin β metalloproteases associated with differential metabolite profiles in the plasma and urine of mice with type 1 diabetes and diabetic nephropathy

Abstract Background Meprin metalloproteases are abundantly expressed in the brush border membranes of kidney proximal tubules and small intestines. Meprins are also expressed in podocytes and leukocytes (monocytes and macrophages). Meprins are implicated in the pathophysiology of diabetic nephropath...

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Bibliographic Details
Main Authors: Jessica Gooding, Lei Cao, Courtney Whitaker, Jean-Marie Mwiza, Mizpha Fernander, Faihaa Ahmed, Zach Acuff, Susan McRitchie, Susan Sumner, Elimelda Moige Ongeri
Format: Article
Language:English
Published: BMC 2019-04-01
Series:BMC Nephrology
Subjects:
Meprin β metalloprotease
Diabetic kidney injury
Metabolomics
Metabolites
Online Access:http://link.springer.com/article/10.1186/s12882-019-1313-2

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