Inhibitory circuits in cortical layer 5
Inhibitory neurons play a fundamental role in cortical computation and behavior. Recent technological advances, such as two photon imaging, targeted in vivo recording, and molecular profiling, have improved our understanding of the function and diversity of cortical interneurons, but for technical r...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-05-01
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| Series: | Frontiers in Neural Circuits |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncir.2016.00035/full |
| _version_ | 1819055654123339776 |
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| author | Alexander eNaka Hillel eAdesnik Hillel eAdesnik |
| author_facet | Alexander eNaka Hillel eAdesnik Hillel eAdesnik |
| author_sort | Alexander eNaka |
| collection | DOAJ |
| description | Inhibitory neurons play a fundamental role in cortical computation and behavior. Recent technological advances, such as two photon imaging, targeted in vivo recording, and molecular profiling, have improved our understanding of the function and diversity of cortical interneurons, but for technical reasons most work has been directed towards inhibitory neurons in the superficial cortical layers. Here we review current knowledge specifically on layer 5 inhibitory microcircuits, which play a critical role in controlling cortical output. We focus on recent work from the well-studied rodent barrel cortex, but also draw on evidence from studies in primary visual cortex and other cortical areas. The diversity of both deep inhibitory neurons and their pyramidal cell targets make this a challenging but essential area of study in cortical computation and sensory processing. |
| first_indexed | 2024-12-21T13:10:57Z |
| format | Article |
| id | doaj.art-532ced55283148059cffdf327ce92644 |
| institution | Directory Open Access Journal |
| issn | 1662-5110 |
| language | English |
| last_indexed | 2024-12-21T13:10:57Z |
| publishDate | 2016-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neural Circuits |
| spelling | doaj.art-532ced55283148059cffdf327ce926442022-12-21T19:02:53ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102016-05-011010.3389/fncir.2016.00035186156Inhibitory circuits in cortical layer 5Alexander eNaka0Hillel eAdesnik1Hillel eAdesnik2University of California, BerkeleyUniversity of California, BerkeleyUniversity of California, BerkeleyInhibitory neurons play a fundamental role in cortical computation and behavior. Recent technological advances, such as two photon imaging, targeted in vivo recording, and molecular profiling, have improved our understanding of the function and diversity of cortical interneurons, but for technical reasons most work has been directed towards inhibitory neurons in the superficial cortical layers. Here we review current knowledge specifically on layer 5 inhibitory microcircuits, which play a critical role in controlling cortical output. We focus on recent work from the well-studied rodent barrel cortex, but also draw on evidence from studies in primary visual cortex and other cortical areas. The diversity of both deep inhibitory neurons and their pyramidal cell targets make this a challenging but essential area of study in cortical computation and sensory processing.http://journal.frontiersin.org/Journal/10.3389/fncir.2016.00035/fullNeocortexbarrel cortexconnectivityinhibitioninterneuronlayer 5 |
| spellingShingle | Alexander eNaka Hillel eAdesnik Hillel eAdesnik Inhibitory circuits in cortical layer 5 Frontiers in Neural Circuits Neocortex barrel cortex connectivity inhibition interneuron layer 5 |
| title | Inhibitory circuits in cortical layer 5 |
| title_full | Inhibitory circuits in cortical layer 5 |
| title_fullStr | Inhibitory circuits in cortical layer 5 |
| title_full_unstemmed | Inhibitory circuits in cortical layer 5 |
| title_short | Inhibitory circuits in cortical layer 5 |
| title_sort | inhibitory circuits in cortical layer 5 |
| topic | Neocortex barrel cortex connectivity inhibition interneuron layer 5 |
| url | http://journal.frontiersin.org/Journal/10.3389/fncir.2016.00035/full |
| work_keys_str_mv | AT alexanderenaka inhibitorycircuitsincorticallayer5 AT hilleleadesnik inhibitorycircuitsincorticallayer5 AT hilleleadesnik inhibitorycircuitsincorticallayer5 |