IFN-γ mediates Paneth cell death via suppression of mTOR

IFN-γ mediates Paneth cell death via suppression of mTOR

Paneth cells constitutively produce antimicrobial peptides and growth factors that allow for intestinal homeostasis, host protection, and intestinal stem cell replication. Paneth cells rely heavily on the glycolytic metabolic program, which is in part controlled by the kinase complex Mechanistic tar...

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Bibliographic Details
Main Authors: Alessandra Araujo, Alexandra Safronova, Elise Burger, Américo López-Yglesias, Shilpi Giri, Ellie T Camanzo, Andrew T Martin, Sergei Grivennikov, Felix Yarovinsky
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-10-01
Series:eLife
Subjects:
IFN-gamma
Paneth cells
cell death
intestine
mTOR
Toxoplasma
Online Access:https://elifesciences.org/articles/60478

Internet

https://elifesciences.org/articles/60478

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