Extracellular vesicles in osteoarthritis of peripheral joint and temporomandibular joint
Osteoarthritis (OA) is a disabling disease with significant morbidity worldwide. OA attacks the large synovial joint, including the peripheral joints and temporomandibular joint (TMJ). As a representative of peripheral joint OA, knee OA shares similar symptoms with TMJ OA. However, these two joints...
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| Format: | Article |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1158744/full |
| _version_ | 1827998418526535680 |
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| author | Benyi Yang Xin Li Xin Li Chaoran Fu Wenyi Cai Wenyi Cai Bowen Meng Yan Qu Xiaoxing Kou Qingbin Zhang Qingbin Zhang |
| author_facet | Benyi Yang Xin Li Xin Li Chaoran Fu Wenyi Cai Wenyi Cai Bowen Meng Yan Qu Xiaoxing Kou Qingbin Zhang Qingbin Zhang |
| author_sort | Benyi Yang |
| collection | DOAJ |
| description | Osteoarthritis (OA) is a disabling disease with significant morbidity worldwide. OA attacks the large synovial joint, including the peripheral joints and temporomandibular joint (TMJ). As a representative of peripheral joint OA, knee OA shares similar symptoms with TMJ OA. However, these two joints also display differences based on their distinct development, anatomy, and physiology. Extracellular vesicles (EVs) are phospholipid bilayer nanoparticles, including exosomes, microvesicles, and apoptotic bodies. EVs contain proteins, lipids, DNA, micro-RNA, and mRNA that regulate tissue homeostasis and cell-to-cell communication, which play an essential role in the progression and treatment of OA. They are likely to partake in mechanical response, extracellular matrix degradation, and inflammatory regulation during OA. More evidence has shown that synovial fluid and synovium-derived EVs may serve as OA biomarkers. More importantly, mesenchymal stem cell-derived EV shows a therapeutic effect on OA. However, the different function of EVs in these two joints is largely unknown based on their distinct biological characteristic. Here, we reviewed the effects of EVs in OA progression and compared the difference between the knee joint and TMJ, and summarized their potential therapeutic role in the treatment of OA. |
| first_indexed | 2024-04-10T05:43:05Z |
| format | Article |
| id | doaj.art-532dc001b25e41d5815dab9d05beb9cd |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-10T05:43:05Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-532dc001b25e41d5815dab9d05beb9cd2023-03-06T05:38:43ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-03-011410.3389/fendo.2023.11587441158744Extracellular vesicles in osteoarthritis of peripheral joint and temporomandibular jointBenyi Yang0Xin Li1Xin Li2Chaoran Fu3Wenyi Cai4Wenyi Cai5Bowen Meng6Yan Qu7Xiaoxing Kou8Qingbin Zhang9Qingbin Zhang10Guangdong Provincial Key Laboratory of Stomatology Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, South China Center of Craniofacial Stem Cell Research, Guangzhou, ChinaDepartment of Temporomandibular Joint, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, ChinaGuangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Stomatology Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, South China Center of Craniofacial Stem Cell Research, Guangzhou, ChinaDepartment of Temporomandibular Joint, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, ChinaGuangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Stomatology Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, South China Center of Craniofacial Stem Cell Research, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Stomatology Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, South China Center of Craniofacial Stem Cell Research, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Stomatology Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, South China Center of Craniofacial Stem Cell Research, Guangzhou, ChinaDepartment of Temporomandibular Joint, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, ChinaGuangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou, ChinaOsteoarthritis (OA) is a disabling disease with significant morbidity worldwide. OA attacks the large synovial joint, including the peripheral joints and temporomandibular joint (TMJ). As a representative of peripheral joint OA, knee OA shares similar symptoms with TMJ OA. However, these two joints also display differences based on their distinct development, anatomy, and physiology. Extracellular vesicles (EVs) are phospholipid bilayer nanoparticles, including exosomes, microvesicles, and apoptotic bodies. EVs contain proteins, lipids, DNA, micro-RNA, and mRNA that regulate tissue homeostasis and cell-to-cell communication, which play an essential role in the progression and treatment of OA. They are likely to partake in mechanical response, extracellular matrix degradation, and inflammatory regulation during OA. More evidence has shown that synovial fluid and synovium-derived EVs may serve as OA biomarkers. More importantly, mesenchymal stem cell-derived EV shows a therapeutic effect on OA. However, the different function of EVs in these two joints is largely unknown based on their distinct biological characteristic. Here, we reviewed the effects of EVs in OA progression and compared the difference between the knee joint and TMJ, and summarized their potential therapeutic role in the treatment of OA.https://www.frontiersin.org/articles/10.3389/fendo.2023.1158744/fullosteoarthritisTMJperipheral jointextracellular vesiclesEV therapy |
| spellingShingle | Benyi Yang Xin Li Xin Li Chaoran Fu Wenyi Cai Wenyi Cai Bowen Meng Yan Qu Xiaoxing Kou Qingbin Zhang Qingbin Zhang Extracellular vesicles in osteoarthritis of peripheral joint and temporomandibular joint Frontiers in Endocrinology osteoarthritis TMJ peripheral joint extracellular vesicles EV therapy |
| title | Extracellular vesicles in osteoarthritis of peripheral joint and temporomandibular joint |
| title_full | Extracellular vesicles in osteoarthritis of peripheral joint and temporomandibular joint |
| title_fullStr | Extracellular vesicles in osteoarthritis of peripheral joint and temporomandibular joint |
| title_full_unstemmed | Extracellular vesicles in osteoarthritis of peripheral joint and temporomandibular joint |
| title_short | Extracellular vesicles in osteoarthritis of peripheral joint and temporomandibular joint |
| title_sort | extracellular vesicles in osteoarthritis of peripheral joint and temporomandibular joint |
| topic | osteoarthritis TMJ peripheral joint extracellular vesicles EV therapy |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1158744/full |
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