Interaction between microbiota and immunity and its implication in colorectal cancer
Colorectal cancer (CRC) is one of the leading causes of cancer-related death in the world. Besides genetic causes, colonic inflammation is one of the major risk factors for CRC development, which is synergistically regulated by multiple components, including innate and adaptive immune cells, cytokin...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.963819/full |
| _version_ | 1818163529939681280 |
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| author | Changsheng Xing Yang Du Tianhao Duan Kelly Nim Junjun Chu Helen Y. Wang Rong-Fu Wang Rong-Fu Wang Rong-Fu Wang |
| author_facet | Changsheng Xing Yang Du Tianhao Duan Kelly Nim Junjun Chu Helen Y. Wang Rong-Fu Wang Rong-Fu Wang Rong-Fu Wang |
| author_sort | Changsheng Xing |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is one of the leading causes of cancer-related death in the world. Besides genetic causes, colonic inflammation is one of the major risk factors for CRC development, which is synergistically regulated by multiple components, including innate and adaptive immune cells, cytokine signaling, and microbiota. The complex interaction between CRC and the gut microbiome has emerged as an important area of current CRC research. Metagenomic profiling has identified a number of prominent CRC-associated bacteria that are enriched in CRC patients, linking the microbiota composition to colitis and cancer development. Some microbiota species have been reported to promote colitis and CRC development in preclinical models, while a few others are identified as immune modulators to induce potent protective immunity against colitis and CRC. Mechanistically, microbiota regulates the activation of different immune cell populations, inflammation, and CRC via crosstalk between innate and adaptive immune signaling pathways, including nuclear factor kappa B (NF-κB), type I interferon, and inflammasome. In this review, we provide an overview of the potential interactions between gut microbiota and host immunity and how their crosstalk could synergistically regulate inflammation and CRC, thus highlighting the potential roles and mechanisms of gut microbiota in the development of microbiota-based therapies to prevent or alleviate colitis and CRC. |
| first_indexed | 2024-12-11T16:51:01Z |
| format | Article |
| id | doaj.art-532fe09f5e7349ef93bb9594fce506ee |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T16:51:01Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-532fe09f5e7349ef93bb9594fce506ee2022-12-22T00:58:06ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-07-011310.3389/fimmu.2022.963819963819Interaction between microbiota and immunity and its implication in colorectal cancerChangsheng Xing0Yang Du1Tianhao Duan2Kelly Nim3Junjun Chu4Helen Y. Wang5Rong-Fu Wang6Rong-Fu Wang7Rong-Fu Wang8Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United StatesDepartment of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United StatesDepartment of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United StatesDepartment of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United StatesDepartment of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United StatesDepartment of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United StatesDepartment of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United StatesNorris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, United StatesDepartment of Pediatrics, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, United StatesColorectal cancer (CRC) is one of the leading causes of cancer-related death in the world. Besides genetic causes, colonic inflammation is one of the major risk factors for CRC development, which is synergistically regulated by multiple components, including innate and adaptive immune cells, cytokine signaling, and microbiota. The complex interaction between CRC and the gut microbiome has emerged as an important area of current CRC research. Metagenomic profiling has identified a number of prominent CRC-associated bacteria that are enriched in CRC patients, linking the microbiota composition to colitis and cancer development. Some microbiota species have been reported to promote colitis and CRC development in preclinical models, while a few others are identified as immune modulators to induce potent protective immunity against colitis and CRC. Mechanistically, microbiota regulates the activation of different immune cell populations, inflammation, and CRC via crosstalk between innate and adaptive immune signaling pathways, including nuclear factor kappa B (NF-κB), type I interferon, and inflammasome. In this review, we provide an overview of the potential interactions between gut microbiota and host immunity and how their crosstalk could synergistically regulate inflammation and CRC, thus highlighting the potential roles and mechanisms of gut microbiota in the development of microbiota-based therapies to prevent or alleviate colitis and CRC.https://www.frontiersin.org/articles/10.3389/fimmu.2022.963819/fullcolorectal cancermicrobiotainnate immunityadaptive immunitycolitismetabolites |
| spellingShingle | Changsheng Xing Yang Du Tianhao Duan Kelly Nim Junjun Chu Helen Y. Wang Rong-Fu Wang Rong-Fu Wang Rong-Fu Wang Interaction between microbiota and immunity and its implication in colorectal cancer Frontiers in Immunology colorectal cancer microbiota innate immunity adaptive immunity colitis metabolites |
| title | Interaction between microbiota and immunity and its implication in colorectal cancer |
| title_full | Interaction between microbiota and immunity and its implication in colorectal cancer |
| title_fullStr | Interaction between microbiota and immunity and its implication in colorectal cancer |
| title_full_unstemmed | Interaction between microbiota and immunity and its implication in colorectal cancer |
| title_short | Interaction between microbiota and immunity and its implication in colorectal cancer |
| title_sort | interaction between microbiota and immunity and its implication in colorectal cancer |
| topic | colorectal cancer microbiota innate immunity adaptive immunity colitis metabolites |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.963819/full |
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