Siglec-F–expressing neutrophils are essential for creating a profibrotic microenvironment in renal fibrosis

Siglec-F–expressing neutrophils are essential for creating a profibrotic microenvironment in renal fibrosis

The roles of neutrophils in renal inflammation are currently unclear. On examining these cells in the unilateral ureteral obstruction murine model of chronic kidney disease, we found that the injured kidney bore a large and rapidly expanding population of neutrophils that expressed the eosinophil ma...

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Bibliographic Details
Main Authors: Seungwon Ryu, Jae Woo Shin, Soie Kwon, Jiwon Lee, Yong Chul Kim, Yoe-Sik Bae, Yong-Soo Bae, Dong Ki Kim, Yon Su Kim, Seung Hee Yang, Hye Young Kim
Format: Article
Language:English
Published: American Society for Clinical Investigation 2022-06-01
Series:The Journal of Clinical Investigation
Subjects:
Immunology
Nephrology
Online Access:https://doi.org/10.1172/JCI156876

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