Pre-attack and pre-episode symptoms in cluster headache: a multicenter cross-sectional study of 327 Chinese patients
Abstract Background There have been a few studies regarding the pre-attack symptoms (PAS) and pre-episode symptoms (PES) of cluster headache (CH), but none have been conducted in the Chinese population. The purpose of this study was to identify the prevalence and features of PAS and PES in Chinese p...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-07-01
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| Series: | The Journal of Headache and Pain |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s10194-022-01459-z |
| _version_ | 1818015059540967424 |
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| author | Ke Li Shuping Sun Zhanyou Xue Sufen Chen Chunyang Ju Dongmei Hu Xiaoyu Gao Yanhong Wang Dan Wang Jianjun Chen Li Li Jing Liu Mingjie Zhang Zhihua Jia Xun Han Huanxian Liu Mianwang He Wei Zhao Zihua Gong Shuhua Zhang Xiaoxue Lin Yingyuan Liu Shengshu Wang Shengyuan Yu Zhao Dong |
| author_facet | Ke Li Shuping Sun Zhanyou Xue Sufen Chen Chunyang Ju Dongmei Hu Xiaoyu Gao Yanhong Wang Dan Wang Jianjun Chen Li Li Jing Liu Mingjie Zhang Zhihua Jia Xun Han Huanxian Liu Mianwang He Wei Zhao Zihua Gong Shuhua Zhang Xiaoxue Lin Yingyuan Liu Shengshu Wang Shengyuan Yu Zhao Dong |
| author_sort | Ke Li |
| collection | DOAJ |
| description | Abstract Background There have been a few studies regarding the pre-attack symptoms (PAS) and pre-episode symptoms (PES) of cluster headache (CH), but none have been conducted in the Chinese population. The purpose of this study was to identify the prevalence and features of PAS and PES in Chinese patients, as well as to investigate their relationships with pertinent factors. Methods The study included patients who visited a tertiary headache center and nine other headache clinics between January 2019 and September 2021. A questionnaire was used to collect general data and information about PAS and PES. Results Among the 327 patients who met the CH criteria (International Classification of Headache Disorders, 3rd edition), 269 (82.3%) patients experienced at least one PAS. The most common PAS were head and facial discomfort (74.4%). Multivariable logistic regression analysis depicted that the number of triggers (OR = 1.798, p = 0.001), and smoking history (OR = 2.067, p = 0.026) were correlated with increased odds of PAS. In total, 68 (20.8%) patients had PES. The most common symptoms were head and facial discomfort (23, 33.8%). Multivariable logistic regression analysis showed that the number of triggers were associated with increased odds of PES (OR = 1.372, p = 0.005). Conclusions PAS are quite common in CH patients, demonstrating that CH attacks are not comprised of a pain phase alone; investigations of PAS and PES could help researchers better understand the pathophysiology of CH. |
| first_indexed | 2024-04-14T06:53:17Z |
| format | Article |
| id | doaj.art-5336807cb8954dca8c0571aa14771ef3 |
| institution | Directory Open Access Journal |
| issn | 1129-2369 1129-2377 |
| language | English |
| last_indexed | 2024-04-14T06:53:17Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | The Journal of Headache and Pain |
| spelling | doaj.art-5336807cb8954dca8c0571aa14771ef32022-12-22T02:06:58ZengBMCThe Journal of Headache and Pain1129-23691129-23772022-07-0123111010.1186/s10194-022-01459-zPre-attack and pre-episode symptoms in cluster headache: a multicenter cross-sectional study of 327 Chinese patientsKe Li0Shuping Sun1Zhanyou Xue2Sufen Chen3Chunyang Ju4Dongmei Hu5Xiaoyu Gao6Yanhong Wang7Dan Wang8Jianjun Chen9Li Li10Jing Liu11Mingjie Zhang12Zhihua Jia13Xun Han14Huanxian Liu15Mianwang He16Wei Zhao17Zihua Gong18Shuhua Zhang19Xiaoxue Lin20Yingyuan Liu21Shengshu Wang22Shengyuan Yu23Zhao Dong24Department of Neurology, the First Medical Center, Chinese PLA General HospitalDepartment of Neurology, the First Medical Center, Chinese PLA General HospitalDepartment of Neurology, Suzhou Blue Cross Brain HospitalDepartment of Neurology, Changsha Central Hospital affiliated to University of South ChinaDepartment of Neurology, Xuchang Central Hospital Affiliated to Henan University of Science and TechnologyDepartment of Neurology, The Second Affiliated Hospital of Shandong First Medical UniversityDepartment of Neurology, the Affiliated Yantai Yuhuangding Hospital of Qingdao UniversityDepartment of Neurology, Changchun Hospital of traditional Chinese medicineDepartment of Neurology, General Hospital of Northern Theatre commandDepartment of Neurology, Lishui Municipal Central HospitalDepartment of Neurology, Jincheng General HospitalDepartment of Neurology, the First Medical Center, Chinese PLA General HospitalDepartment of Neurology, the First Medical Center, Chinese PLA General HospitalDepartment of Neurology, the First Medical Center, Chinese PLA General HospitalDepartment of Neurology, the First Medical Center, Chinese PLA General HospitalDepartment of Neurology, the First Medical Center, Chinese PLA General HospitalDepartment of Neurology, the First Medical Center, Chinese PLA General HospitalDepartment of Neurology, the First Medical Center, Chinese PLA General HospitalDepartment of Neurology, the First Medical Center, Chinese PLA General HospitalDepartment of Neurology, the First Medical Center, Chinese PLA General HospitalDepartment of Neurology, the First Medical Center, Chinese PLA General HospitalDepartment of Neurology, the First Medical Center, Chinese PLA General HospitalInstitude of geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatrics Diseases, the 2nd Medical Center, Chinese PLA General HospitalDepartment of Neurology, the First Medical Center, Chinese PLA General HospitalDepartment of Neurology, the First Medical Center, Chinese PLA General HospitalAbstract Background There have been a few studies regarding the pre-attack symptoms (PAS) and pre-episode symptoms (PES) of cluster headache (CH), but none have been conducted in the Chinese population. The purpose of this study was to identify the prevalence and features of PAS and PES in Chinese patients, as well as to investigate their relationships with pertinent factors. Methods The study included patients who visited a tertiary headache center and nine other headache clinics between January 2019 and September 2021. A questionnaire was used to collect general data and information about PAS and PES. Results Among the 327 patients who met the CH criteria (International Classification of Headache Disorders, 3rd edition), 269 (82.3%) patients experienced at least one PAS. The most common PAS were head and facial discomfort (74.4%). Multivariable logistic regression analysis depicted that the number of triggers (OR = 1.798, p = 0.001), and smoking history (OR = 2.067, p = 0.026) were correlated with increased odds of PAS. In total, 68 (20.8%) patients had PES. The most common symptoms were head and facial discomfort (23, 33.8%). Multivariable logistic regression analysis showed that the number of triggers were associated with increased odds of PES (OR = 1.372, p = 0.005). Conclusions PAS are quite common in CH patients, demonstrating that CH attacks are not comprised of a pain phase alone; investigations of PAS and PES could help researchers better understand the pathophysiology of CH.https://doi.org/10.1186/s10194-022-01459-zCluster headachePre-attack symptomsPre-episode symptoms |
| spellingShingle | Ke Li Shuping Sun Zhanyou Xue Sufen Chen Chunyang Ju Dongmei Hu Xiaoyu Gao Yanhong Wang Dan Wang Jianjun Chen Li Li Jing Liu Mingjie Zhang Zhihua Jia Xun Han Huanxian Liu Mianwang He Wei Zhao Zihua Gong Shuhua Zhang Xiaoxue Lin Yingyuan Liu Shengshu Wang Shengyuan Yu Zhao Dong Pre-attack and pre-episode symptoms in cluster headache: a multicenter cross-sectional study of 327 Chinese patients The Journal of Headache and Pain Cluster headache Pre-attack symptoms Pre-episode symptoms |
| title | Pre-attack and pre-episode symptoms in cluster headache: a multicenter cross-sectional study of 327 Chinese patients |
| title_full | Pre-attack and pre-episode symptoms in cluster headache: a multicenter cross-sectional study of 327 Chinese patients |
| title_fullStr | Pre-attack and pre-episode symptoms in cluster headache: a multicenter cross-sectional study of 327 Chinese patients |
| title_full_unstemmed | Pre-attack and pre-episode symptoms in cluster headache: a multicenter cross-sectional study of 327 Chinese patients |
| title_short | Pre-attack and pre-episode symptoms in cluster headache: a multicenter cross-sectional study of 327 Chinese patients |
| title_sort | pre attack and pre episode symptoms in cluster headache a multicenter cross sectional study of 327 chinese patients |
| topic | Cluster headache Pre-attack symptoms Pre-episode symptoms |
| url | https://doi.org/10.1186/s10194-022-01459-z |
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