Collective force generated by multiple biofilaments can exceed the sum of forces due to individual ones
Collective dynamics and force generation by cytoskeletal filaments are crucial in many cellular processes. Investigating growth dynamics of a bundle of N independent cytoskeletal filaments pushing against a wall, we show that chemical switching (ATP/GTP hydrolysis) leads to a collective phenomenon t...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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IOP Publishing
2014-01-01
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| Series: | New Journal of Physics |
| Subjects: | |
| Online Access: | https://doi.org/10.1088/1367-2630/16/6/063032 |
| _version_ | 1827874100120387584 |
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| author | Dipjyoti Das Dibyendu Das Ranjith Padinhateeri |
| author_facet | Dipjyoti Das Dibyendu Das Ranjith Padinhateeri |
| author_sort | Dipjyoti Das |
| collection | DOAJ |
| description | Collective dynamics and force generation by cytoskeletal filaments are crucial in many cellular processes. Investigating growth dynamics of a bundle of N independent cytoskeletal filaments pushing against a wall, we show that chemical switching (ATP/GTP hydrolysis) leads to a collective phenomenon that is currently unknown. Obtaining force-velocity relations for different models that capture chemical switching, we show, analytically and numerically, that the collective stall force of N filaments is greater than N times the stall force of a single filament. Employing an exactly solvable toy model, we analytically prove the above result for N = 2. We, further, numerically show the existence of this collective phenomenon, for $N\geqslant 2$ , in realistic models (with random and sequential hydrolysis) that simulate actin and microtubule bundle growth. We make quantitative predictions for the excess forces, and argue that this collective effect is related to the non-equilibrium nature of chemical switching. |
| first_indexed | 2024-03-12T16:47:28Z |
| format | Article |
| id | doaj.art-5336aa262e4e433d890e503fdc6508e2 |
| institution | Directory Open Access Journal |
| issn | 1367-2630 |
| language | English |
| last_indexed | 2024-03-12T16:47:28Z |
| publishDate | 2014-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | New Journal of Physics |
| spelling | doaj.art-5336aa262e4e433d890e503fdc6508e22023-08-08T11:29:35ZengIOP PublishingNew Journal of Physics1367-26302014-01-0116606303210.1088/1367-2630/16/6/063032Collective force generated by multiple biofilaments can exceed the sum of forces due to individual onesDipjyoti Das0Dibyendu Das1Ranjith Padinhateeri2Department of Physics, Indian Institute of Technology, Bombay , Powai, Mumbai-400 076, IndiaDepartment of Physics, Indian Institute of Technology, Bombay , Powai, Mumbai-400 076, IndiaDepartment of Biosciences and Bioengineering, Indian Institute of Technology , Bombay, Powai, Mumbai-400 076, IndiaCollective dynamics and force generation by cytoskeletal filaments are crucial in many cellular processes. Investigating growth dynamics of a bundle of N independent cytoskeletal filaments pushing against a wall, we show that chemical switching (ATP/GTP hydrolysis) leads to a collective phenomenon that is currently unknown. Obtaining force-velocity relations for different models that capture chemical switching, we show, analytically and numerically, that the collective stall force of N filaments is greater than N times the stall force of a single filament. Employing an exactly solvable toy model, we analytically prove the above result for N = 2. We, further, numerically show the existence of this collective phenomenon, for $N\geqslant 2$ , in realistic models (with random and sequential hydrolysis) that simulate actin and microtubule bundle growth. We make quantitative predictions for the excess forces, and argue that this collective effect is related to the non-equilibrium nature of chemical switching.https://doi.org/10.1088/1367-2630/16/6/063032non-equilibrium chemical switchingdynamics of biofilamentscollective force generationactin and microtubules87.16.A-87.16.Ka |
| spellingShingle | Dipjyoti Das Dibyendu Das Ranjith Padinhateeri Collective force generated by multiple biofilaments can exceed the sum of forces due to individual ones New Journal of Physics non-equilibrium chemical switching dynamics of biofilaments collective force generation actin and microtubules 87.16.A- 87.16.Ka |
| title | Collective force generated by multiple biofilaments can exceed the sum of forces due to individual ones |
| title_full | Collective force generated by multiple biofilaments can exceed the sum of forces due to individual ones |
| title_fullStr | Collective force generated by multiple biofilaments can exceed the sum of forces due to individual ones |
| title_full_unstemmed | Collective force generated by multiple biofilaments can exceed the sum of forces due to individual ones |
| title_short | Collective force generated by multiple biofilaments can exceed the sum of forces due to individual ones |
| title_sort | collective force generated by multiple biofilaments can exceed the sum of forces due to individual ones |
| topic | non-equilibrium chemical switching dynamics of biofilaments collective force generation actin and microtubules 87.16.A- 87.16.Ka |
| url | https://doi.org/10.1088/1367-2630/16/6/063032 |
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