Caffeic Acid Phenethyl Ester Ameliorates Calcification by Inhibiting Activation of the AKT/NF-κB/NLRP3 Inflammasome Pathway in Human Aortic Valve Interstitial Cells

Caffeic Acid Phenethyl Ester Ameliorates Calcification by Inhibiting Activation of the AKT/NF-κB/NLRP3 Inflammasome Pathway in Human Aortic Valve Interstitial Cells

Calcific aortic valve disease (CAVD) occurs via a pathophysiological process that includes inflammation-induced osteoblastic differentiation of aortic valvular interstitial cells (AVICs). Here, we investigated the role of the anti-inflammatory compound caffeic acid phenethyl ester (CAPE) in inhibiti...

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Bibliographic Details
Main Authors: Ming Liu, Fei Li, Yuming Huang, Tingwen Zhou, Si Chen, Geng Li, Jiawei Shi, Nianguo Dong, Kang Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Pharmacology
Subjects:
human aortic valve disease
natural product
polyphenolic compound
NF-κB pathway
inflammasome
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00826/full

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