Is There Any Relationship Between Serum Endocan Levels and Carotid Intima-media Thickness in Patients with Fibromyalgia?
Objective:Although the pathophysiology of Fibromyalgia syndrome (FMS) has not yet been completely elucidated, it has been suggested that inflammation and endothelial dysfunction occur in patients with FMS. In recent years, endocan has been reported as an important biomarker for inflammation and endo...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2019-08-01
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| Series: | Türk Osteoporoz Dergisi |
| Subjects: | |
| Online Access: |
http://www.turkosteoporozdergisi.org/archives/archive-detail/article-preview/s-there-any-relationship-between-serum-endocan-lev/27932
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| _version_ | 1797907775144067072 |
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| author | Fatih Bağcıer Fatih Hakan Tufanoğlu Özgür Kadıçeşme |
| author_facet | Fatih Bağcıer Fatih Hakan Tufanoğlu Özgür Kadıçeşme |
| author_sort | Fatih Bağcıer |
| collection | DOAJ |
| description | Objective:Although the pathophysiology of Fibromyalgia syndrome (FMS) has not yet been completely elucidated, it has been suggested that inflammation and endothelial dysfunction occur in patients with FMS. In recent years, endocan has been reported as an important biomarker for inflammation and endothelial dysfunction. It is important to assess carotid intima-media thickness (CIMT) in the evaluation of early atherosclerotic vascular diseases. In this study, we investigated this mechanism by measuring serum endocan levels and CIMT in patients with FMS and evaluated whether there is a correlation between them.Materials and Methods:Serum samples collected from 40 female patients diagnosed with FMS (the patient group) for the first time and 40 healthy female participants’ (the control group) endocan levels and CIMT ultrasonography were investigated, and the values of the two groups were compared.Results:Serum endocan levels and CIMT results were significantly higher in the patient group than in the control group (p<0.001). In addition, a very weak correlation was found between CIMT and endocan levels in patients with FMS.Conclusion:Increased subclinical inflammation, endothelial dysfunction, and early atherosclerosis play an important role in the pathophysiology of FMS. Increased endocan levels, CIMT, and the correlation between them will contribute to elucidating this mechanism. |
| first_indexed | 2024-04-10T10:42:06Z |
| format | Article |
| id | doaj.art-533867e8a14c4e1e9f850fdc5cef4781 |
| institution | Directory Open Access Journal |
| issn | 2147-2653 2147-2653 |
| language | English |
| last_indexed | 2024-04-10T10:42:06Z |
| publishDate | 2019-08-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Osteoporoz Dergisi |
| spelling | doaj.art-533867e8a14c4e1e9f850fdc5cef47812023-02-15T16:20:29ZengGalenos YayineviTürk Osteoporoz Dergisi2147-26532147-26532019-08-01252495210.4274/tod.galenos.2019.1602313049054Is There Any Relationship Between Serum Endocan Levels and Carotid Intima-media Thickness in Patients with Fibromyalgia?Fatih Bağcıer0Fatih Hakan Tufanoğlu1Özgür Kadıçeşme2 Kars Harakani State Hospital, Clinic of Physical Theraphy and Rehabilitation, Kars, Turkey Kars Harakani State Hospital, Clinic of Radiology, Kars, Turkey Kars Harakani State Hospital, Clinic of Biochemistry, Kars, Turkey Objective:Although the pathophysiology of Fibromyalgia syndrome (FMS) has not yet been completely elucidated, it has been suggested that inflammation and endothelial dysfunction occur in patients with FMS. In recent years, endocan has been reported as an important biomarker for inflammation and endothelial dysfunction. It is important to assess carotid intima-media thickness (CIMT) in the evaluation of early atherosclerotic vascular diseases. In this study, we investigated this mechanism by measuring serum endocan levels and CIMT in patients with FMS and evaluated whether there is a correlation between them.Materials and Methods:Serum samples collected from 40 female patients diagnosed with FMS (the patient group) for the first time and 40 healthy female participants’ (the control group) endocan levels and CIMT ultrasonography were investigated, and the values of the two groups were compared.Results:Serum endocan levels and CIMT results were significantly higher in the patient group than in the control group (p<0.001). In addition, a very weak correlation was found between CIMT and endocan levels in patients with FMS.Conclusion:Increased subclinical inflammation, endothelial dysfunction, and early atherosclerosis play an important role in the pathophysiology of FMS. Increased endocan levels, CIMT, and the correlation between them will contribute to elucidating this mechanism. http://www.turkosteoporozdergisi.org/archives/archive-detail/article-preview/s-there-any-relationship-between-serum-endocan-lev/27932 Carotid intima-media thicknessfibromyalgiaendocancorrelation |
| spellingShingle | Fatih Bağcıer Fatih Hakan Tufanoğlu Özgür Kadıçeşme Is There Any Relationship Between Serum Endocan Levels and Carotid Intima-media Thickness in Patients with Fibromyalgia? Türk Osteoporoz Dergisi Carotid intima-media thickness fibromyalgia endocan correlation |
| title | Is There Any Relationship Between Serum Endocan Levels and Carotid Intima-media Thickness in Patients with Fibromyalgia? |
| title_full | Is There Any Relationship Between Serum Endocan Levels and Carotid Intima-media Thickness in Patients with Fibromyalgia? |
| title_fullStr | Is There Any Relationship Between Serum Endocan Levels and Carotid Intima-media Thickness in Patients with Fibromyalgia? |
| title_full_unstemmed | Is There Any Relationship Between Serum Endocan Levels and Carotid Intima-media Thickness in Patients with Fibromyalgia? |
| title_short | Is There Any Relationship Between Serum Endocan Levels and Carotid Intima-media Thickness in Patients with Fibromyalgia? |
| title_sort | is there any relationship between serum endocan levels and carotid intima media thickness in patients with fibromyalgia |
| topic | Carotid intima-media thickness fibromyalgia endocan correlation |
| url |
http://www.turkosteoporozdergisi.org/archives/archive-detail/article-preview/s-there-any-relationship-between-serum-endocan-lev/27932
|
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