In vitro evaluation of the antimicrobial activity of antiseptics against clinical Acinetobacter baumannii strains isolated from combat wounds
Healthcare-associated infections (HCAIs) are among the most prominent medical problems worldwide. In the context of increasing antibiotic resistance globally, the use of antiseptics as the main active agent and potentiator of antibiotics for the treatment of purulent-inflammatory complications of tr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.932467/full |
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| author | Tetyana Valeriyivna Denysko Oleksandr Adamovych Nazarchuk Oleksandr Gruzevskyi Nataliia Ànatoliivna Bahniuk Dmytro Valeriiovych Dmytriiev Roman Mykolayovych Chornopyschuk Vira Volodymyrivna Bebyk |
| author_facet | Tetyana Valeriyivna Denysko Oleksandr Adamovych Nazarchuk Oleksandr Gruzevskyi Nataliia Ànatoliivna Bahniuk Dmytro Valeriiovych Dmytriiev Roman Mykolayovych Chornopyschuk Vira Volodymyrivna Bebyk |
| author_sort | Tetyana Valeriyivna Denysko |
| collection | DOAJ |
| description | Healthcare-associated infections (HCAIs) are among the most prominent medical problems worldwide. In the context of increasing antibiotic resistance globally, the use of antiseptics as the main active agent and potentiator of antibiotics for the treatment of purulent-inflammatory complications of traumatic wounds, burns, and surgical wounds can be considered to tackle opportunistic infections and their prevention during war. This study presents a comparative investigation of the antimicrobial efficacy of antiseptics used for surgical antisepsis and antiseptic treatment of skin, mucous membranes, and wounds against multidrug-resistant clinical isolates of Acinetobacter baumannii as a wound pathogen of critical priority (according to the WHO). It was found that strains of A. baumannii, which have natural and acquired resistance to antimicrobial drugs, remain susceptible to modern antiseptics. Antiseptic drugs based on decamethoxine, chlorhexidine, octenidine, polyhexanide, and povidone-iodine 10% and 2% provide effective bactericidal activity against A. baumannii within the working concentrations of these drugs. Chlorhexidine and decamethoxine can inhibit biofilm formation by A. baumannii cells. In terms of bactericidal properties and biofilm formation inhibition, chlorhexidine and decamethoxine are the most effective of all tested antiseptics. |
| first_indexed | 2024-04-12T13:55:46Z |
| format | Article |
| id | doaj.art-5338944e9b1f49d78eb0a688beeab960 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-12T13:55:46Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-5338944e9b1f49d78eb0a688beeab9602022-12-22T03:30:22ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-10-011310.3389/fmicb.2022.932467932467In vitro evaluation of the antimicrobial activity of antiseptics against clinical Acinetobacter baumannii strains isolated from combat woundsTetyana Valeriyivna Denysko0Oleksandr Adamovych Nazarchuk1Oleksandr Gruzevskyi2Nataliia Ànatoliivna Bahniuk3Dmytro Valeriiovych Dmytriiev4Roman Mykolayovych Chornopyschuk5Vira Volodymyrivna Bebyk6Department of Microbiology, Virology and Immunology, National Pirogov Memorial Medical University, Vinnytsya, UkraineDepartment of Microbiology, Virology and Immunology, National Pirogov Memorial Medical University, Vinnytsya, UkraineDepartment of Microbiology, Virology and Immunology Odessa National Medical University, Odessa, UkraineDepartment of Microbiology, Virology and Immunology, National Pirogov Memorial Medical University, Vinnytsya, UkraineDepartment of Anesthesiology, Intensive care, and Emergency Medicine, National Pirogov Memorial Medical University, Vinnytsya, UkraineDepartment of General Surgery, National Pirogov Memorial Medical University, Vinnytsya, UkraineDepartment of Microbiology, Virology and Immunology, National Pirogov Memorial Medical University, Vinnytsya, UkraineHealthcare-associated infections (HCAIs) are among the most prominent medical problems worldwide. In the context of increasing antibiotic resistance globally, the use of antiseptics as the main active agent and potentiator of antibiotics for the treatment of purulent-inflammatory complications of traumatic wounds, burns, and surgical wounds can be considered to tackle opportunistic infections and their prevention during war. This study presents a comparative investigation of the antimicrobial efficacy of antiseptics used for surgical antisepsis and antiseptic treatment of skin, mucous membranes, and wounds against multidrug-resistant clinical isolates of Acinetobacter baumannii as a wound pathogen of critical priority (according to the WHO). It was found that strains of A. baumannii, which have natural and acquired resistance to antimicrobial drugs, remain susceptible to modern antiseptics. Antiseptic drugs based on decamethoxine, chlorhexidine, octenidine, polyhexanide, and povidone-iodine 10% and 2% provide effective bactericidal activity against A. baumannii within the working concentrations of these drugs. Chlorhexidine and decamethoxine can inhibit biofilm formation by A. baumannii cells. In terms of bactericidal properties and biofilm formation inhibition, chlorhexidine and decamethoxine are the most effective of all tested antiseptics.https://www.frontiersin.org/articles/10.3389/fmicb.2022.932467/fullAcinetobacter baumanniiantisepticsinfectioncombat woundresistancebiofilms |
| spellingShingle | Tetyana Valeriyivna Denysko Oleksandr Adamovych Nazarchuk Oleksandr Gruzevskyi Nataliia Ànatoliivna Bahniuk Dmytro Valeriiovych Dmytriiev Roman Mykolayovych Chornopyschuk Vira Volodymyrivna Bebyk In vitro evaluation of the antimicrobial activity of antiseptics against clinical Acinetobacter baumannii strains isolated from combat wounds Frontiers in Microbiology Acinetobacter baumannii antiseptics infection combat wound resistance biofilms |
| title | In vitro evaluation of the antimicrobial activity of antiseptics against clinical Acinetobacter baumannii strains isolated from combat wounds |
| title_full | In vitro evaluation of the antimicrobial activity of antiseptics against clinical Acinetobacter baumannii strains isolated from combat wounds |
| title_fullStr | In vitro evaluation of the antimicrobial activity of antiseptics against clinical Acinetobacter baumannii strains isolated from combat wounds |
| title_full_unstemmed | In vitro evaluation of the antimicrobial activity of antiseptics against clinical Acinetobacter baumannii strains isolated from combat wounds |
| title_short | In vitro evaluation of the antimicrobial activity of antiseptics against clinical Acinetobacter baumannii strains isolated from combat wounds |
| title_sort | in vitro evaluation of the antimicrobial activity of antiseptics against clinical acinetobacter baumannii strains isolated from combat wounds |
| topic | Acinetobacter baumannii antiseptics infection combat wound resistance biofilms |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.932467/full |
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