Intraoperative microelectrode recording under general anesthesia guided subthalamic nucleus deep brain stimulation for Parkinson's disease: One institution's experience
ObjectiveMicroelectrode recording (MER) guided subthalamic nucleus deep brain stimulation (STN-DBS) under local anesthesia (LA) is widely applied in the management of advanced Parkinson's disease (PD). Whereas, awake DBS under LA is painful and burdensome for PD patients. We analyzed the influe...
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1117681/full |
| _version_ | 1797895834607550464 |
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| author | Kang Qian Jiajing Wang Jing Rao Peng Zhang Yaqiang Sun Yaqiang Sun Wenqing Hu Wenqing Hu Jie Hao Jie Hao Xiaobing Jiang Peng Fu |
| author_facet | Kang Qian Jiajing Wang Jing Rao Peng Zhang Yaqiang Sun Yaqiang Sun Wenqing Hu Wenqing Hu Jie Hao Jie Hao Xiaobing Jiang Peng Fu |
| author_sort | Kang Qian |
| collection | DOAJ |
| description | ObjectiveMicroelectrode recording (MER) guided subthalamic nucleus deep brain stimulation (STN-DBS) under local anesthesia (LA) is widely applied in the management of advanced Parkinson's disease (PD). Whereas, awake DBS under LA is painful and burdensome for PD patients. We analyzed the influence of general anesthesia (GA) on intraoperative MER, to assess the feasibility and effectiveness of GA in MER guided STN-DBS.MethodsRetrospective analysis was performed on the PD patients, who underwent bilateral MER guided STN-DBS in Wuhan Union Hospital from July 2019 to December 2021. The patients were assigned to LA or GA group according to the anesthetic methods implemented. Multidimensional parameters, including MER signals, electrode implantation accuracy, clinical outcome and adverse events, were analyzed.ResultsA total of 40 PD patients were enrolled in this study, including 18 in LA group and 22 in GA group. There were no statistically significant differences in patient demographics and baseline characteristics between two groups. Although, the parameters of MER signal, including frequency, inter-spike interval (ISI) and amplitude, were obviously interfered under GA, the waveforms of MER signals were recognizable and shared similar characteristics with LA group. Both LA and GA could achieve effective electrode implantation accuracy and clinical outcome. They also shared similar adverse events postoperatively.ConclusionGA is viable and comparable to LA in MER guided STN-DBS for PD, regarding electrode implantation accuracy, clinical outcome and adverse events. Notably, GA is more friendly and acceptable to the patients who are incapable of enduring intraoperative MER under LA. |
| first_indexed | 2024-04-10T07:31:59Z |
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| id | doaj.art-53394a7c3007490ea074512f4c068d52 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-10T07:31:59Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-53394a7c3007490ea074512f4c068d522023-02-23T13:40:49ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-02-011410.3389/fneur.2023.11176811117681Intraoperative microelectrode recording under general anesthesia guided subthalamic nucleus deep brain stimulation for Parkinson's disease: One institution's experienceKang Qian0Jiajing Wang1Jing Rao2Peng Zhang3Yaqiang Sun4Yaqiang Sun5Wenqing Hu6Wenqing Hu7Jie Hao8Jie Hao9Xiaobing Jiang10Peng Fu11Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaWuhan National Laboratory for Optoelectronics, Britton Chance Center for Biomedical Photonics, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Automation, Chinese Academy of Sciences, Beijing, ChinaGuangdong Institute of Artificial Intelligence and Advanced Computing, Guangzhou, ChinaInstitute of Automation, Chinese Academy of Sciences, Beijing, ChinaGuangdong Institute of Artificial Intelligence and Advanced Computing, Guangzhou, ChinaInstitute of Automation, Chinese Academy of Sciences, Beijing, ChinaGuangdong Institute of Artificial Intelligence and Advanced Computing, Guangzhou, ChinaDepartment of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaObjectiveMicroelectrode recording (MER) guided subthalamic nucleus deep brain stimulation (STN-DBS) under local anesthesia (LA) is widely applied in the management of advanced Parkinson's disease (PD). Whereas, awake DBS under LA is painful and burdensome for PD patients. We analyzed the influence of general anesthesia (GA) on intraoperative MER, to assess the feasibility and effectiveness of GA in MER guided STN-DBS.MethodsRetrospective analysis was performed on the PD patients, who underwent bilateral MER guided STN-DBS in Wuhan Union Hospital from July 2019 to December 2021. The patients were assigned to LA or GA group according to the anesthetic methods implemented. Multidimensional parameters, including MER signals, electrode implantation accuracy, clinical outcome and adverse events, were analyzed.ResultsA total of 40 PD patients were enrolled in this study, including 18 in LA group and 22 in GA group. There were no statistically significant differences in patient demographics and baseline characteristics between two groups. Although, the parameters of MER signal, including frequency, inter-spike interval (ISI) and amplitude, were obviously interfered under GA, the waveforms of MER signals were recognizable and shared similar characteristics with LA group. Both LA and GA could achieve effective electrode implantation accuracy and clinical outcome. They also shared similar adverse events postoperatively.ConclusionGA is viable and comparable to LA in MER guided STN-DBS for PD, regarding electrode implantation accuracy, clinical outcome and adverse events. Notably, GA is more friendly and acceptable to the patients who are incapable of enduring intraoperative MER under LA.https://www.frontiersin.org/articles/10.3389/fneur.2023.1117681/fullgeneral anesthesialocal anesthesiamicroelectrode recordingsubthalamic nucleus deep brain stimulationParkinson's disease |
| spellingShingle | Kang Qian Jiajing Wang Jing Rao Peng Zhang Yaqiang Sun Yaqiang Sun Wenqing Hu Wenqing Hu Jie Hao Jie Hao Xiaobing Jiang Peng Fu Intraoperative microelectrode recording under general anesthesia guided subthalamic nucleus deep brain stimulation for Parkinson's disease: One institution's experience Frontiers in Neurology general anesthesia local anesthesia microelectrode recording subthalamic nucleus deep brain stimulation Parkinson's disease |
| title | Intraoperative microelectrode recording under general anesthesia guided subthalamic nucleus deep brain stimulation for Parkinson's disease: One institution's experience |
| title_full | Intraoperative microelectrode recording under general anesthesia guided subthalamic nucleus deep brain stimulation for Parkinson's disease: One institution's experience |
| title_fullStr | Intraoperative microelectrode recording under general anesthesia guided subthalamic nucleus deep brain stimulation for Parkinson's disease: One institution's experience |
| title_full_unstemmed | Intraoperative microelectrode recording under general anesthesia guided subthalamic nucleus deep brain stimulation for Parkinson's disease: One institution's experience |
| title_short | Intraoperative microelectrode recording under general anesthesia guided subthalamic nucleus deep brain stimulation for Parkinson's disease: One institution's experience |
| title_sort | intraoperative microelectrode recording under general anesthesia guided subthalamic nucleus deep brain stimulation for parkinson s disease one institution s experience |
| topic | general anesthesia local anesthesia microelectrode recording subthalamic nucleus deep brain stimulation Parkinson's disease |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1117681/full |
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