Light-Driven Synthetic Biology: Progress in Research and Industrialization of Cyanobacterial Cell Factory
Light-driven synthetic biology refers to an autotrophic microorganisms-based research platform that remodels microbial metabolism through synthetic biology and directly converts light energy into bio-based chemicals. This technology can help achieve the goal of carbon neutrality while promoting gree...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/12/10/1537 |
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| author | Chaofeng Li Jiyang Zheng Yushuang Wu Xiaotong Wang Hui Shao Dong Yan |
| author_facet | Chaofeng Li Jiyang Zheng Yushuang Wu Xiaotong Wang Hui Shao Dong Yan |
| author_sort | Chaofeng Li |
| collection | DOAJ |
| description | Light-driven synthetic biology refers to an autotrophic microorganisms-based research platform that remodels microbial metabolism through synthetic biology and directly converts light energy into bio-based chemicals. This technology can help achieve the goal of carbon neutrality while promoting green production. Cyanobacteria are photosynthetic microorganisms that use light and CO<sub>2</sub> for growth and production. They thus possess unique advantages as “autotrophic cell factories”. Various fuels and chemicals have been synthesized by cyanobacteria, indicating their important roles in research and industrial application. This review summarized the progresses and remaining challenges in light-driven cyanobacterial cell factory. The choice of chassis cells, strategies used in metabolic engineering, and the methods for high-value CO<sub>2</sub> utilization will be discussed. |
| first_indexed | 2024-03-09T03:34:30Z |
| format | Article |
| id | doaj.art-533ec8fa7f434683a329cef65af9fc09 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T03:34:30Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-533ec8fa7f434683a329cef65af9fc092023-12-03T14:50:00ZengMDPI AGLife2075-17292022-10-011210153710.3390/life12101537Light-Driven Synthetic Biology: Progress in Research and Industrialization of Cyanobacterial Cell FactoryChaofeng Li0Jiyang Zheng1Yushuang Wu2Xiaotong Wang3Hui Shao4Dong Yan5Shanghai Lumy Biotechnology Co., Ltd., Shanghai 201100, ChinaShanghai Lumy Biotechnology Co., Ltd., Shanghai 201100, ChinaShanghai Lumy Biotechnology Co., Ltd., Shanghai 201100, ChinaShanghai Lumy Biotechnology Co., Ltd., Shanghai 201100, ChinaShanghai Lumy Biotechnology Co., Ltd., Shanghai 201100, ChinaShanghai Lumy Biotechnology Co., Ltd., Shanghai 201100, ChinaLight-driven synthetic biology refers to an autotrophic microorganisms-based research platform that remodels microbial metabolism through synthetic biology and directly converts light energy into bio-based chemicals. This technology can help achieve the goal of carbon neutrality while promoting green production. Cyanobacteria are photosynthetic microorganisms that use light and CO<sub>2</sub> for growth and production. They thus possess unique advantages as “autotrophic cell factories”. Various fuels and chemicals have been synthesized by cyanobacteria, indicating their important roles in research and industrial application. This review summarized the progresses and remaining challenges in light-driven cyanobacterial cell factory. The choice of chassis cells, strategies used in metabolic engineering, and the methods for high-value CO<sub>2</sub> utilization will be discussed.https://www.mdpi.com/2075-1729/12/10/1537synthetic biologycyanobacteriabiosynthesismetabolic engineeringCO<sub>2</sub> utilization |
| spellingShingle | Chaofeng Li Jiyang Zheng Yushuang Wu Xiaotong Wang Hui Shao Dong Yan Light-Driven Synthetic Biology: Progress in Research and Industrialization of Cyanobacterial Cell Factory Life synthetic biology cyanobacteria biosynthesis metabolic engineering CO<sub>2</sub> utilization |
| title | Light-Driven Synthetic Biology: Progress in Research and Industrialization of Cyanobacterial Cell Factory |
| title_full | Light-Driven Synthetic Biology: Progress in Research and Industrialization of Cyanobacterial Cell Factory |
| title_fullStr | Light-Driven Synthetic Biology: Progress in Research and Industrialization of Cyanobacterial Cell Factory |
| title_full_unstemmed | Light-Driven Synthetic Biology: Progress in Research and Industrialization of Cyanobacterial Cell Factory |
| title_short | Light-Driven Synthetic Biology: Progress in Research and Industrialization of Cyanobacterial Cell Factory |
| title_sort | light driven synthetic biology progress in research and industrialization of cyanobacterial cell factory |
| topic | synthetic biology cyanobacteria biosynthesis metabolic engineering CO<sub>2</sub> utilization |
| url | https://www.mdpi.com/2075-1729/12/10/1537 |
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