Immunity against hepatitis B in a selected child population in Gampaha district, Sri Lanka, ten years after vaccination at two, four and six months of age
<p><strong>Background</strong>: Hepatitis B (HB) infections are a global public health concern, which carry high morbidity and mortality. Immunization is the safe and effective intervention to prevent transmission. Currently, the Hepatitis B vaccine is given to children at two, fou...
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| Format: | Article |
| Language: | English |
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Sri Lankan Society for Microbiology
2022-02-01
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| Series: | Sri Lankan Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | https://sljid.sljol.info/articles/8419 |
| _version_ | 1797985095564394496 |
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| author | PJ Perera MD Fernando M Hapugoda L Udayanga |
| author_facet | PJ Perera MD Fernando M Hapugoda L Udayanga |
| author_sort | PJ Perera |
| collection | DOAJ |
| description | <p><strong>Background</strong>: Hepatitis B (HB) infections are a global public health concern, which carry high morbidity and mortality. Immunization is the safe and effective intervention to prevent transmission. Currently, the Hepatitis B vaccine is given to children at two, four and six months of age in Sri Lanka. However, the capability of this regimen in providing long term protection up to adolescence and beyond remains a concern. The current study was conducted to assess the HB immune status of children, ten years after vaccination during infancy.</p><p><strong> </strong></p><p><strong>Methods: </strong>Antibody status of 150 children who received HB vaccine at two, four and six months of age was assessed 10 years after the last dose of vaccination. Some of these children had received liquid monovalent HB vaccine, while others were vaccinated with the Hexavalent vaccine. Children with HB antibody levels below the protective level were given a booster dose of monovalent recombinant HB vaccine, and antibody levels were reassessed in one month.</p><p><strong> </strong></p><p><strong>Results: </strong>At the initial assessment, 128 children (85%) had protective levels of antibodies. Type of vaccine and gender had no significant effect on the prevalence of HB antibody levels (p>0.05). All children who received the booster dose developed protective levels of antibodies.</p><p><strong> </strong></p><p><strong>Conclusions: </strong>Most of the children immunized against HB during infancy maintain protective antibody levels at 10 years of age. Children with antibody levels below protective levels produced a rapid anamnestic response following a booster dose.</p><p>.</p> |
| first_indexed | 2024-04-11T07:13:13Z |
| format | Article |
| id | doaj.art-5340a1e546414c9cb0f0efb5201ecf31 |
| institution | Directory Open Access Journal |
| issn | 2012-8169 2448-9654 |
| language | English |
| last_indexed | 2024-04-11T07:13:13Z |
| publishDate | 2022-02-01 |
| publisher | Sri Lankan Society for Microbiology |
| record_format | Article |
| series | Sri Lankan Journal of Infectious Diseases |
| spelling | doaj.art-5340a1e546414c9cb0f0efb5201ecf312022-12-22T04:38:06ZengSri Lankan Society for MicrobiologySri Lankan Journal of Infectious Diseases2012-81692448-96542022-02-011211810.4038/sljid.v12i1.84195946Immunity against hepatitis B in a selected child population in Gampaha district, Sri Lanka, ten years after vaccination at two, four and six months of agePJ Perera0MD Fernando1M Hapugoda2L Udayanga3Faculty of Medicine, University of KelaniyaFaculty of Medicine, University of KelaniyaFaculty of Medicine, University of KelaniyaFaculty of Medicine, University of Kelaniya<p><strong>Background</strong>: Hepatitis B (HB) infections are a global public health concern, which carry high morbidity and mortality. Immunization is the safe and effective intervention to prevent transmission. Currently, the Hepatitis B vaccine is given to children at two, four and six months of age in Sri Lanka. However, the capability of this regimen in providing long term protection up to adolescence and beyond remains a concern. The current study was conducted to assess the HB immune status of children, ten years after vaccination during infancy.</p><p><strong> </strong></p><p><strong>Methods: </strong>Antibody status of 150 children who received HB vaccine at two, four and six months of age was assessed 10 years after the last dose of vaccination. Some of these children had received liquid monovalent HB vaccine, while others were vaccinated with the Hexavalent vaccine. Children with HB antibody levels below the protective level were given a booster dose of monovalent recombinant HB vaccine, and antibody levels were reassessed in one month.</p><p><strong> </strong></p><p><strong>Results: </strong>At the initial assessment, 128 children (85%) had protective levels of antibodies. Type of vaccine and gender had no significant effect on the prevalence of HB antibody levels (p>0.05). All children who received the booster dose developed protective levels of antibodies.</p><p><strong> </strong></p><p><strong>Conclusions: </strong>Most of the children immunized against HB during infancy maintain protective antibody levels at 10 years of age. Children with antibody levels below protective levels produced a rapid anamnestic response following a booster dose.</p><p>.</p>https://sljid.sljol.info/articles/8419hepatitis b, immunity, immunization, antibodies |
| spellingShingle | PJ Perera MD Fernando M Hapugoda L Udayanga Immunity against hepatitis B in a selected child population in Gampaha district, Sri Lanka, ten years after vaccination at two, four and six months of age Sri Lankan Journal of Infectious Diseases hepatitis b, immunity, immunization, antibodies |
| title | Immunity against hepatitis B in a selected child population in Gampaha district, Sri Lanka, ten years after vaccination at two, four and six months of age |
| title_full | Immunity against hepatitis B in a selected child population in Gampaha district, Sri Lanka, ten years after vaccination at two, four and six months of age |
| title_fullStr | Immunity against hepatitis B in a selected child population in Gampaha district, Sri Lanka, ten years after vaccination at two, four and six months of age |
| title_full_unstemmed | Immunity against hepatitis B in a selected child population in Gampaha district, Sri Lanka, ten years after vaccination at two, four and six months of age |
| title_short | Immunity against hepatitis B in a selected child population in Gampaha district, Sri Lanka, ten years after vaccination at two, four and six months of age |
| title_sort | immunity against hepatitis b in a selected child population in gampaha district sri lanka ten years after vaccination at two four and six months of age |
| topic | hepatitis b, immunity, immunization, antibodies |
| url | https://sljid.sljol.info/articles/8419 |
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