A unique case report of endobronchial cryptococcosis and review of the literature
Cryptococcosis is an infection caused by the yeast-like fungus Cryptococcus neoformans. Pulmonary cryptococcosis is typically identified as a single mass or as multiple nodules, while endobronchial lesions are quite rare. Here we report an uncommon case of pulmonary cryptococcosis presenting as endo...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-01-01
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| Series: | Respiratory Medicine Case Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213007118300819 |
| _version_ | 1818910051708960768 |
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| author | Shi-Yuan Shuai Liang Xiong Xin-Liang He Fan Yu Qin Xia Qiong Zhou |
| author_facet | Shi-Yuan Shuai Liang Xiong Xin-Liang He Fan Yu Qin Xia Qiong Zhou |
| author_sort | Shi-Yuan Shuai |
| collection | DOAJ |
| description | Cryptococcosis is an infection caused by the yeast-like fungus Cryptococcus neoformans. Pulmonary cryptococcosis is typically identified as a single mass or as multiple nodules, while endobronchial lesions are quite rare. Here we report an uncommon case of pulmonary cryptococcosis presenting as endobronchial lesion in an immunocompetent patient. A 49-year-old male patient complained of intermittent cough with hemoptysis for two years. Computerized tomography of the chest showed a filling defect in the basal segment of the right lower lobe bronchus. A flexible bronchoscopic examination revealed a white smooth-surfaced polypoid lesion completely occluding the medial basal segment of the right lower lobe bronchus. The diagnosis was confirmed by bronchial biopsy under bronchoscopy, and the histopathologic findings showed the organisms were Cryptococcal neoformans. The patient was treated with fluconazole at a dose of 400 mg daily. The endobronchial lesion was found rapidly diminished after 18 days of therapy, and disappeared after 6.5 months of therapy by repeated fiberoptic bronchoscopy. Then the patient continued fluconazole for another 2.5 months. During the total 16 months' follow-up visits, the patient repeated CT scanning for five times, the results of which were all normal. The patient's symptoms disappeared as well, and now he is still under follow-up. This case highlights the fact that pulmonary cryptococcosis can present as endobronchial lesions even in immunocompetent subjects, mimicking lung tumor. Pathological confirmation is important to establish the definite diagnosis. Keywords: Case report, Cryptococcosis, Endobronchial mass, Pulmonary cryptococcosis |
| first_indexed | 2024-12-19T22:36:40Z |
| format | Article |
| id | doaj.art-5346b96e5b8f4ed0981c823d8ee03006 |
| institution | Directory Open Access Journal |
| issn | 2213-0071 |
| language | English |
| last_indexed | 2024-12-19T22:36:40Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj.art-5346b96e5b8f4ed0981c823d8ee030062022-12-21T20:03:11ZengElsevierRespiratory Medicine Case Reports2213-00712018-01-0125247252A unique case report of endobronchial cryptococcosis and review of the literatureShi-Yuan Shuai0Liang Xiong1Xin-Liang He2Fan Yu3Qin Xia4Qiong Zhou5Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Corresponding author.Cryptococcosis is an infection caused by the yeast-like fungus Cryptococcus neoformans. Pulmonary cryptococcosis is typically identified as a single mass or as multiple nodules, while endobronchial lesions are quite rare. Here we report an uncommon case of pulmonary cryptococcosis presenting as endobronchial lesion in an immunocompetent patient. A 49-year-old male patient complained of intermittent cough with hemoptysis for two years. Computerized tomography of the chest showed a filling defect in the basal segment of the right lower lobe bronchus. A flexible bronchoscopic examination revealed a white smooth-surfaced polypoid lesion completely occluding the medial basal segment of the right lower lobe bronchus. The diagnosis was confirmed by bronchial biopsy under bronchoscopy, and the histopathologic findings showed the organisms were Cryptococcal neoformans. The patient was treated with fluconazole at a dose of 400 mg daily. The endobronchial lesion was found rapidly diminished after 18 days of therapy, and disappeared after 6.5 months of therapy by repeated fiberoptic bronchoscopy. Then the patient continued fluconazole for another 2.5 months. During the total 16 months' follow-up visits, the patient repeated CT scanning for five times, the results of which were all normal. The patient's symptoms disappeared as well, and now he is still under follow-up. This case highlights the fact that pulmonary cryptococcosis can present as endobronchial lesions even in immunocompetent subjects, mimicking lung tumor. Pathological confirmation is important to establish the definite diagnosis. Keywords: Case report, Cryptococcosis, Endobronchial mass, Pulmonary cryptococcosishttp://www.sciencedirect.com/science/article/pii/S2213007118300819 |
| spellingShingle | Shi-Yuan Shuai Liang Xiong Xin-Liang He Fan Yu Qin Xia Qiong Zhou A unique case report of endobronchial cryptococcosis and review of the literature Respiratory Medicine Case Reports |
| title | A unique case report of endobronchial cryptococcosis and review of the literature |
| title_full | A unique case report of endobronchial cryptococcosis and review of the literature |
| title_fullStr | A unique case report of endobronchial cryptococcosis and review of the literature |
| title_full_unstemmed | A unique case report of endobronchial cryptococcosis and review of the literature |
| title_short | A unique case report of endobronchial cryptococcosis and review of the literature |
| title_sort | unique case report of endobronchial cryptococcosis and review of the literature |
| url | http://www.sciencedirect.com/science/article/pii/S2213007118300819 |
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