Synthesis and Characterization of Some New Pyrazoline and Isoxazoline Derivatives as Antibacterial Agents
In this paper some chalcones (C1-C8) are prepared based on the reaction of one mole of substituted acetophenone with one mole of substituted benzaldehydes in the presence of (40%) sodium hydroxide as a base. Pyrazolines (P1–P8) are prepared from the reaction of chalcones (C1-C8) with hydrazine hydra...
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| Format: | Article |
| Language: | Arabic |
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College of Science for Women, University of Baghdad
2016-09-01
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| Series: | Baghdad Science Journal |
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| Online Access: | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2300 |
| _version_ | 1811295522403647488 |
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| author | Baghdad Science Journal |
| author_facet | Baghdad Science Journal |
| author_sort | Baghdad Science Journal |
| collection | DOAJ |
| description | In this paper some chalcones (C1-C8) are prepared based on the reaction of one mole of substituted acetophenone with one mole of substituted benzaldehydes in the presence of (40%) sodium hydroxide as a base. Pyrazolines (P1–P8) are prepared from the reaction of chalcones (C1-C8) with hydrazine hydrate.
Isoxazoline (I1-I8) is prepared from the reaction of chalcones (C1-C8) with hydroxyl amine hydrochloride in the presence of (10%) sodium hydroxide as a base. These compounds are characterized by using various physical and spectral methods. The compounds are screened for their in vitro antibacterial activity using gram-positive bacteria and gram-negative bacteria. Several derivatives of pyrazolines and isoxazolines are produced well to moderate activities against number of bacteria. |
| first_indexed | 2024-04-13T05:33:49Z |
| format | Article |
| id | doaj.art-5348d55776044cd49918b63ddb8262df |
| institution | Directory Open Access Journal |
| issn | 2078-8665 2411-7986 |
| language | Arabic |
| last_indexed | 2024-04-13T05:33:49Z |
| publishDate | 2016-09-01 |
| publisher | College of Science for Women, University of Baghdad |
| record_format | Article |
| series | Baghdad Science Journal |
| spelling | doaj.art-5348d55776044cd49918b63ddb8262df2022-12-22T03:00:20ZaraCollege of Science for Women, University of BaghdadBaghdad Science Journal2078-86652411-79862016-09-0113310.21123/bsj.13.3.568-577Synthesis and Characterization of Some New Pyrazoline and Isoxazoline Derivatives as Antibacterial AgentsBaghdad Science JournalIn this paper some chalcones (C1-C8) are prepared based on the reaction of one mole of substituted acetophenone with one mole of substituted benzaldehydes in the presence of (40%) sodium hydroxide as a base. Pyrazolines (P1–P8) are prepared from the reaction of chalcones (C1-C8) with hydrazine hydrate. Isoxazoline (I1-I8) is prepared from the reaction of chalcones (C1-C8) with hydroxyl amine hydrochloride in the presence of (10%) sodium hydroxide as a base. These compounds are characterized by using various physical and spectral methods. The compounds are screened for their in vitro antibacterial activity using gram-positive bacteria and gram-negative bacteria. Several derivatives of pyrazolines and isoxazolines are produced well to moderate activities against number of bacteria.http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2300"Chalcones, Pyrazolines, Isoxazolines, Antibacterial" |
| spellingShingle | Baghdad Science Journal Synthesis and Characterization of Some New Pyrazoline and Isoxazoline Derivatives as Antibacterial Agents Baghdad Science Journal "Chalcones, Pyrazolines, Isoxazolines, Antibacterial" |
| title | Synthesis and Characterization of Some New Pyrazoline and Isoxazoline Derivatives as Antibacterial Agents |
| title_full | Synthesis and Characterization of Some New Pyrazoline and Isoxazoline Derivatives as Antibacterial Agents |
| title_fullStr | Synthesis and Characterization of Some New Pyrazoline and Isoxazoline Derivatives as Antibacterial Agents |
| title_full_unstemmed | Synthesis and Characterization of Some New Pyrazoline and Isoxazoline Derivatives as Antibacterial Agents |
| title_short | Synthesis and Characterization of Some New Pyrazoline and Isoxazoline Derivatives as Antibacterial Agents |
| title_sort | synthesis and characterization of some new pyrazoline and isoxazoline derivatives as antibacterial agents |
| topic | "Chalcones, Pyrazolines, Isoxazolines, Antibacterial" |
| url | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2300 |
| work_keys_str_mv | AT baghdadsciencejournal synthesisandcharacterizationofsomenewpyrazolineandisoxazolinederivativesasantibacterialagents |