Bacterial sigma factors as targets for engineered or synthetic transcriptional control
Sigma (σ) factors are the predominant constituents of transcription regulation in bacteria. σ factors recruit the core RNA polymerase (RNAP) to recognize promoters with specific DNA sequences. Recently engineering of transcriptional regulators has become a significant tool for strain engineering. Th...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-09-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fbioe.2014.00033/full |
| Summary: | Sigma (σ) factors are the predominant constituents of transcription regulation in bacteria. σ factors recruit the core RNA polymerase (RNAP) to recognize promoters with specific DNA sequences. Recently engineering of transcriptional regulators has become a significant tool for strain engineering. The present review summarizes the recent advances in σ factor based engineering or synthetic design. The manipulation of σ factors presents insights into the bacterial stress tolerance and metabolite productivity. We envision more synthetic design based on σ factors that can be used to tune the regulatory network of bacteria. |
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| ISSN: | 2296-4185 |