Role of thioredoxin in chronic obstructive pulmonary disease (COPD): a promising future target
Abstract Introduction Thioredoxin (Trx) is a secretory protein that acts as an antioxidant, redox regulator, anti-allergic, and anti-inflammatory molecule. It has been used to treat dermatitis and inflammation of the digestive tract. In the lungs, Trx has a significant anti-inflammatory impact. On t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12931-023-02574-4 |
| _version_ | 1797451752104001536 |
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| author | Heena Kansal Vishal Chopra Kranti Garg Siddharth Sharma |
| author_facet | Heena Kansal Vishal Chopra Kranti Garg Siddharth Sharma |
| author_sort | Heena Kansal |
| collection | DOAJ |
| description | Abstract Introduction Thioredoxin (Trx) is a secretory protein that acts as an antioxidant, redox regulator, anti-allergic, and anti-inflammatory molecule. It has been used to treat dermatitis and inflammation of the digestive tract. In the lungs, Trx has a significant anti-inflammatory impact. On the other hand, Chronic Obstructive Pulmonary Disease (COPD) is one of the significant causes of death in the developed world, with a tremendous individual and socioeconomic impact. Despite new initiatives and endless treatment trials, COPD incidence and death will likely escalate in the coming decades. Areas covered COPD is a chronic inflammatory disease impacting the airways, lung parenchyma, and pulmonary vasculature. Oxidative stress and protease-antiprotease imbalances are thought to be involved in the process. The most popular respiratory inflammatory and allergic disorders therapies are corticosteroids and β-receptor agonists. These medications are helpful but have some drawbacks, such as infection and immunosuppression; thus, addressing Trx signalling treatments may be a viable COPD treatment approach. This review shall cover the pathophysiology of COPD, the pharmacognosy of anti-COPD drugs, including the assets and liabilities of each, and the role and mechanism of Trx in COPD treatment. Expert opinion Limited research has targeted the thioredoxin system as an anti-COPD drug. Spectating the increase in the mortality rates of COPD, this review article would be an interesting one to research. |
| first_indexed | 2024-03-09T14:58:58Z |
| format | Article |
| id | doaj.art-534c8db7103f4f1d9868a7ac4e3688d2 |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-03-09T14:58:58Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-534c8db7103f4f1d9868a7ac4e3688d22023-11-26T14:02:00ZengBMCRespiratory Research1465-993X2023-11-0124111810.1186/s12931-023-02574-4Role of thioredoxin in chronic obstructive pulmonary disease (COPD): a promising future targetHeena Kansal0Vishal Chopra1Kranti Garg2Siddharth Sharma3Department of Biotechnology, Thapar Institute of Engineering and TechnologyDepartment of Pulmonary Medicine, Government Medical CollegeDepartment of Pulmonary Medicine, Government Medical CollegeDepartment of Biotechnology, Thapar Institute of Engineering and TechnologyAbstract Introduction Thioredoxin (Trx) is a secretory protein that acts as an antioxidant, redox regulator, anti-allergic, and anti-inflammatory molecule. It has been used to treat dermatitis and inflammation of the digestive tract. In the lungs, Trx has a significant anti-inflammatory impact. On the other hand, Chronic Obstructive Pulmonary Disease (COPD) is one of the significant causes of death in the developed world, with a tremendous individual and socioeconomic impact. Despite new initiatives and endless treatment trials, COPD incidence and death will likely escalate in the coming decades. Areas covered COPD is a chronic inflammatory disease impacting the airways, lung parenchyma, and pulmonary vasculature. Oxidative stress and protease-antiprotease imbalances are thought to be involved in the process. The most popular respiratory inflammatory and allergic disorders therapies are corticosteroids and β-receptor agonists. These medications are helpful but have some drawbacks, such as infection and immunosuppression; thus, addressing Trx signalling treatments may be a viable COPD treatment approach. This review shall cover the pathophysiology of COPD, the pharmacognosy of anti-COPD drugs, including the assets and liabilities of each, and the role and mechanism of Trx in COPD treatment. Expert opinion Limited research has targeted the thioredoxin system as an anti-COPD drug. Spectating the increase in the mortality rates of COPD, this review article would be an interesting one to research.https://doi.org/10.1186/s12931-023-02574-4COPDThioredoxinOxidative stressInflammationROS |
| spellingShingle | Heena Kansal Vishal Chopra Kranti Garg Siddharth Sharma Role of thioredoxin in chronic obstructive pulmonary disease (COPD): a promising future target Respiratory Research COPD Thioredoxin Oxidative stress Inflammation ROS |
| title | Role of thioredoxin in chronic obstructive pulmonary disease (COPD): a promising future target |
| title_full | Role of thioredoxin in chronic obstructive pulmonary disease (COPD): a promising future target |
| title_fullStr | Role of thioredoxin in chronic obstructive pulmonary disease (COPD): a promising future target |
| title_full_unstemmed | Role of thioredoxin in chronic obstructive pulmonary disease (COPD): a promising future target |
| title_short | Role of thioredoxin in chronic obstructive pulmonary disease (COPD): a promising future target |
| title_sort | role of thioredoxin in chronic obstructive pulmonary disease copd a promising future target |
| topic | COPD Thioredoxin Oxidative stress Inflammation ROS |
| url | https://doi.org/10.1186/s12931-023-02574-4 |
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